References
- ^Grundmann OPatterns of Kratom use and health impact in the US-Results from an online survey.Drug Alcohol Depend.(2017-Jul-01)
- ^WHO Expert Committee on Specifications for Pharmaceutical Preparations. Forty-fourth report
Nausea and constipation may occur after kratom ingestion, especially if taken in higher amounts and/or more frequently.[1] High doses of kratom might also trigger rare serious adverse events such as hallucinations, tremor, seizure, coma, and respiratory depression. The active alkaloid in kratom (mitragynine) has been found in a number of postmortem analyses, in addition to other substances (e.g., fentanyl, heroin, benzodiazepines). Because of the presence of these other substances, it is unknown whether and how kratom contributed to the cause of death. Finally, chronic kratom use can lead to dependence and precipitate an opioid-like withdrawal, including symptoms of agitation, nausea, and vomiting.[2]