L-Dopa

Last Updated: September 28 2022

L-DOPA is a direct precursor to dopamine, and its supplementation can increase dopamine levels in the body. It is known as Levodopa and is one component of most Parkinson's treatments, and found in high amounts in Mucuna Pruriens.

L-Dopa is most often used for

What else is L-Dopa known as?
Note that L-Dopa is also known as:
  • Levodopa
  • L-3
  • 4-dihydroxyphenylalanine
L-Dopa should not be confused with:
Examine Database: L-Dopa
What works and what doesn't?

Unlock the full potential of Examine

Get started

Don't miss out on the latest research

References
4.^García Echeverría CL, Bressani REffect of different cooking treatments of Mucuna beans on its L-Dopa contentArch Latinoam Nutr.(2006 Jun)
5.^Tomita-Yokotani K, Hashimoto H, Fujii Y, Nakamura T, Yamashita MDistribution of L-DOPA in the root of velvet bean plant (Mucuna pruriens L.) and gravityBiol Sci Space.(2004 Nov)
6.^Ramya KB, Thaakur SHerbs containing L- Dopa: An updateAnc Sci Life.(2007 Jul)
10.^Dahouda M, Toléba SS, Youssao AK, Hambuckers A, Dangou-Sapoho R, Martin GB, Fillet M, Hornick JLNutrient digestibility of Mucuna (Mucuna pruriens var. utilis) bean in guinea fowl (Numida meleagris, L): Effects of heat treatment and levels of incorporation in dietsBr Poult Sci.(2009 Sep)
11.^Muhlack S, Woitalla D, Welnic J, Twiehaus S, Przuntek H, Müller TChronic levodopa intake increases levodopa plasma bioavailability in patients with Parkinson's diseaseNeurosci Lett.(2004 Jun 17)
12.^Yamada T, Nakamura J, Murakami M, Okuno Y, Hosokawa S, Matsuo M, Yamada HEffect of chronic L-dopa administration on serum luteinizing hormone levels in male ratsToxicology.(1995 Mar 31)
15.^Boden G, Lundy LE, Owen OEInfluence of levodopa on serum levels of anterior pituitary hormones in manNeuroendocrinology.(1972)
17.^Horita H, Sato Y, Adachi H, Suzuki N, Kato R, Hisasue S, Suzuki K, Tsukamoto TEffects of levodopa on nocturnal penile tumescence: a preliminary studyJ Androl.(1998 Sep-Oct)
18.^Lal S, Ackman D, Thavundayil JX, Kiely ME, Etienne PEffect of apomorphine, a dopamine receptor agonist, on penile tumescence in normal subjectsProg Neuropsychopharmacol Biol Psychiatry.(1984)
19.^Bostwick JM, Hecksel KA, Stevens SR, Bower JH, Ahlskog JEFrequency of new-onset pathologic compulsive gambling or hypersexuality after drug treatment of idiopathic Parkinson diseaseMayo Clin Proc.(2009 Apr)
20.^Klos KJ, Bower JH, Josephs KA, Matsumoto JY, Ahlskog JEPathological hypersexuality predominantly linked to adjuvant dopamine agonist therapy in Parkinson's disease and multiple system atrophyParkinsonism Relat Disord.(2005 Sep)
21.^Both S, Everaerd W, Laan E, Gooren LEffect of a single dose of levodopa on sexual response in men and womenNeuropsychopharmacology.(2005 Jan)
23.^Giuliano F, Allard JDopamine and sexual functionInt J Impot Res.(2001 Aug)
24.^Angrist B, Gershon SClinical effects of amphetamine and L-DOPA on sexuality and aggressionCompr Psychiatry.(1976 Nov-Dec)
25.^Lee EJ, Lee BS, Lee HC, Park KH, Song CH, Huh KBGrowth hormone response to L-dopa and pyridostigmine in women with polycystic ovarian syndromeFertil Steril.(1993 Jul)
26.^Lee EJ, Kim KR, Lee KM, Lim SK, Lee HC, Lee JH, Lee DJ, Huh KBReduced growth hormone response to L-dopa and pyridostigmine in obesityInt J Obes Relat Metab Disord.(1994 Jul)
27.^Cordido F, Peino R, Peñalva A, Alvarez CV, Casanueva FF, Dieguez CImpaired growth hormone secretion in obese subjects is partially reversed by acipimox-mediated plasma free fatty acid depressionJ Clin Endocrinol Metab.(1996 Mar)
31.^Toulouse A, Sullivan AMProgress in Parkinson's disease-where do we standProg Neurobiol.(2008 Aug)
32.^Kang KS, Yamabe N, Wen Y, Fukui M, Zhu BTBeneficial effects of natural phenolics on levodopa methylation and oxidative neurodegenerationBrain Res.(2013 Feb 25)
35.^Hanrieder J, Ljungdahl A, Fälth M, Mammo SE, Bergquist J, Andersson ML-DOPA-induced dyskinesia is associated with regional increase of striatal dynorphin peptides as elucidated by imaging mass spectrometryMol Cell Proteomics.(2011 Oct)
36.^Nisbet AP, Foster OJ, Kingsbury A, Eve DJ, Daniel SE, Marsden CD, Lees AJPreproenkephalin and preprotachykinin messenger RNA expression in normal human basal ganglia and in Parkinson's diseaseNeuroscience.(1995 May)
37.^Henry B, Duty S, Fox SH, Crossman AR, Brotchie JMIncreased striatal pre-proenkephalin B expression is associated with dyskinesia in Parkinson's diseaseExp Neurol.(2003 Oct)
38.^Calon F, Birdi S, Rajput AH, Hornykiewicz O, Bédard PJ, Di Paolo TIncrease of preproenkephalin mRNA levels in the putamen of Parkinson disease patients with levodopa-induced dyskinesiasJ Neuropathol Exp Neurol.(2002 Feb)
43.^Boyce S, Rupniak NM, Steventon MJ, Iversen SDNigrostriatal damage is required for induction of dyskinesias by L-DOPA in squirrel monkeysClin Neuropharmacol.(1990 Oct)