How does Lavender work?

    Last Updated: November 28, 2023

    Lavender is believed to have an effect on the limbic system of the brain, which controls mood and memory. It additionally increases the activity of the parasympathetic nervous system, which could reduce the stress response in the body. There also seems to be an impact on the 5HT1A receptor, which has been implicated in anxiety. Reduced binding to this receptor could explain the anxiolytic effects of lavender.[1][2]

    Voltage-dependent calcium channels (VDCC) are thought to be related to the inappropriate stress response found in the central nervous system of those with anxiety and other mood disorders. Lavender inhibits these channels, and thus attenuates this response. Lavender also increases the amount of serotonin in the system by blocking the serotonin transporters (SERT). SERT are presynaptic receptors that move serotonin from the synapse back into the cell. Blocking these transporters leaves more extracellular serotonin available to the brain, which can improve mood and anxiety symptoms. While this mechanism is similar to the way some antidepressant medications, such as SSRIs, work, there are also some differences, and lavender has a less significant effect on overall serotonin levels than antidepressant medications.[3][4]

    References

    1. ^Cavanagh HM, Wilkinson JMBiological activities of lavender essential oilPhytother Res.(2002 Jun)
    2. ^Malcolm BJ, Tallian KEssential oil of lavender in anxiety disorders: Ready for prime time?Ment Health Clin.(2018 Mar 26)
    3. ^Dold M, Bartova L, Volz HP, Seifritz E, Möller HJ, Schläfke S, Kasper SEfficacy of Silexan in patients with anxiety disorders: a meta-analysis of randomized, placebo-controlled trials.Eur Arch Psychiatry Clin Neurosci.(2023-Jan-30)
    4. ^López V, Nielsen B, Solas M, Ramírez MJ, Jäger AKExploring Pharmacological Mechanisms of Lavender (Lavandula angustifolia) Essential Oil on Central Nervous System TargetsFront Pharmacol.(2017 May 19)