In vitro and animal studies observed additional benefits associated with lion’s mane supplementation; although clinical research has not yet confirmed these findings.
In a study using topically wounded rats and lion's mane water extract, it was observed that the accumulation of immune cells in the wound was reduced in the lion's mane group compared to the control.[1]
Additionally, lion’s mane fruiting body extract was found to reduce triglyceride levels in hyperlipidemic rats and increase the expression of several genes involved in fat metabolism, thus mitigating weight gain during a high-fat diet.[2] On the other hand, the mycelium of lion’s mane appeared to have cholesterol-reducing properties.[3]
Finally, one in vitro study showed that lion’s mane extract displayed antioxidant activity, likely due to its phenolic component. It also exhibited antimicrobial activity against both Gram-positive and Gram-negative bacteria, with specificity for certain bacteria depending on the extraction solvent used. Furthermore, the ethanolic extract showed dose-dependent cytotoxic activity against lung adenocarcinoma cells.[4]
References
- ^Abdulla MA, Fard AA, Sabaratnam V, Wong KH, Kuppusamy UR, Abdullah N, Ismail SPotential activity of aqueous extract of culinary-medicinal Lion's Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats.Int J Med Mushrooms.(2011)
- ^Hiwatashi K, Kosaka Y, Suzuki N, Hata K, Mukaiyama T, Sakamoto K, Shirakawa H, Komai MYamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat diet.Biosci Biotechnol Biochem.(2010)
- ^Yang BK, Park JB, Song CHHypolipidemic effect of an Exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus.Biosci Biotechnol Biochem.(2003-Jun)
- ^Ghosh S, Nandi S, Banerjee A, Sarkar S, Chakraborty N, Acharya KProspecting medicinal properties of Lion's mane mushroom.J Food Biochem.(2021-Jun-24)