Observational studies have found that serum magnesium concentrations are not different between people with and without generalized anxiety disorder[1] and that serum magnesium concentrations are not correlated with self-reported levels of anxiety.[2][3] Some observational studies have found an association between a greater dietary magnesium intake and lower odds of anxiety,[4] but other studies do not confirm that finding.[5][6]
Some clinical trials have compared magnesium to magnesium + pyridoxine (vitamin b6) and found a post-trial decrease in self-reported anxiety and/or stress levels in people in the magnesium group.[7][8][9] However, conclusions concerning the direct effect of magnesium cannot be made from studies lacking a control group who did not take magnesium. Fortunately, there are some randomized controlled trials comparing supplementation with magnesium to a placebo. These studies have mixed outcomes that showed a possible, but weak, effect of magnesium on anxiety.[10][11][12][13][14][15] However, the overall quality of the evidence is low, and high-quality randomized controlled trials are needed.[14][15]
References
- ^Islam MR, Ahmed MU, Mitu SA, Islam MS, Rahman GK, Qusar MM, Hasnat AComparative analysis of serum zinc, copper, manganese, iron, calcium, and magnesium level and complexity of interelement relations in generalized anxiety disorder patients.Biol Trace Elem Res.(2013 Jul)
- ^Bahramy P, Mohammad-Alizadeh-Charandabi S, Ramezani-Nardin F, Mirghafourvand MSerum Levels of Vitamin D, Calcium, Magnesium, and Copper, and their Relations with Mental Health and Sexual Function in Pregnant Iranian Adolescents.Biol Trace Elem Res.(2020 Dec)
- ^Kirov GK, Birch NJ, Steadman P, Ramsey RGPlasma magnesium levels in a population of psychiatric patients: correlations with symptoms.Neuropsychobiology.(1994)
- ^Anjom-Shoae J, Sadeghi O, Hassanzadeh Keshteli A, Afshar H, Esmaillzadeh A, Adibi PThe association between dietary intake of magnesium and psychiatric disorders among Iranian adults: a cross-sectional study.Br J Nutr.(2018 Sep)
- ^Jacka FN, Maes M, Pasco JA, Williams LJ, Berk MNutrient intakes and the common mental disorders in women.J Affect Disord.(2012 Dec 1)
- ^Jacka FN, Overland S, Stewart R, Tell GS, Bjelland I, Mykletun AAssociation between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study.Aust N Z J Psychiatry.(2009 Jan)
- ^Noah L, Dye L, Bois De Fer B, Mazur A, Pickering G, Pouteau EEffect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.Stress Health.(2021-Dec)
- ^Noah L, Pickering G, Mazur A, Dubray C, Hitier S, Dualé C, Pouteau EImpact of magnesium supplementation, in combination with vitamin B6, on stress and magnesium status: secondary data from a randomized controlled trial.Magnes Res.(2020 Aug 1)
- ^Etienne Pouteau, Marmar Kabir-Ahmadi, Lionel Noah, Andre Mazur, Louise Dye, Juliane Hellhammer, Gisele Pickering, Claude DubraySuperiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trialPLoS One.(2018 Dec 18)
- ^Saba S, Faizi F, Sepandi M, Nehrir BEffect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.Magnes Res.(2022-Apr-01)
- ^Tarleton EK, Littenberg B, MacLean CD, Kennedy AG, Daley CRole of magnesium supplementation in the treatment of depression: A randomized clinical trial.PLoS One.(2017)
- ^Fard FE, Mirghafourvand M, Mohammad-Alizadeh Charandabi S, Farshbaf-Khalili A, Javadzadeh Y, Asgharian HEffects of zinc and magnesium supplements on postpartum depression and anxiety: A randomized controlled clinical trialWomen Health.(2017 Oct)
- ^De Souza MC, Walker AF, Robinson PA, Bolland KA synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover studyJ Womens Health Gend Based Med.(2000 Mar)
- ^Botturi A, Ciappolino V, Delvecchio G, Boscutti A, Viscardi B, Brambilla PThe Role and the Effect of Magnesium in Mental Disorders: A Systematic Review.Nutrients.(2020-Jun-03)
- ^Boyle NB, Lawton C, Dye LThe Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic ReviewNutrients.(2017 Apr 26)