Methylliberine is a purine alkaloid found in the seeds and leaves of various coffee plant species. It is theorized that it may produce caffeine-like neuro-energetic effects, with fewer side effects. However, research on methylliberine supplementation in humans is scarce.
In this randomized controlled trial, supplementation with methylliberine, a metabolite of caffeine, did not improve cognitive function in comparison with a placebo.
The effect of a combination of caffeine, theacrine, and methylliberine on cognitive performance and mood