N-phenylacetyl-L-prolylglycine ethyl ester, commonly known as Noopept, is a synthetic pharmaceutical developed by a Russian company and is considered a nootropic due to its potential neuroprotective and cognitive enhancing properties. It was designed based on the structure of piracetam, another nootropic.
What is N-phenylacetyl-L-prolylglycine ethyl ester (Noopept)?
N-phenylacetyl-L-prolylglycine ethyl ester, or Noopept, is a synthetic pharmaceutical designed by a Russian pharmaceutical company. It is sometimes called a nootropic, based on preliminary evidence that it has neuroprotective and cognitive enhancing properties.[1][2][3] Noopept was designed using the structure of piracetam, another nootropic, as a starting point.[4]
What are Noopept’s main benefits?
Noopept may be beneficial for brain health, but this claim is based almost exclusively on studies in which Noopept was administered (often via injection) to rodents with brain damage caused by toxin injection, oxygen deprivation, and other methods.[5][6][7][8][ One of the only controlled trials involving humans found that Noopept supplementation improved cognitive function in a small group of people with mild cognitive impairment (MCI) resulting from a stroke.[9] These findings have not yet been independently replicated.
What are Noopept’s main drawbacks?
Sleep disturbances, irritability, and increases in blood pressure have been reported in people taking Noopept.[10][9] It should be stressed that there is not much research evaluating the safety of Noopept.
Given its similarities to other nootropics like piracetam and ampakines, Noopept may also cause dizziness, headaches, gastrointestinal symptoms, and impairments in memory, although these effects are speculative.[11]
How does Noopept work?
Noopept’s mechanism of action is uncertain, but several possibilities have been proposed. In particular, it may increase levels of brain-derived neurotrophic factor (BDNF), a protein that helps establish neural connections and neurotransmission in the brain.[12] Noopept may also activate or modulate neurotransmitter receptors involved in learning and cognitive function, including certain glutamatergic and cholinergic receptors.[13][14][3]
What are other names for N-Phenylacetyl-L-prolylglycine ethyl ester?
Note that N-Phenylacetyl-L-prolylglycine ethyl ester is also known as:
- Noopeptide
- Ноопепт
- GVS-111
- Noopept
N-Phenylacetyl-L-prolylglycine ethyl ester should not be confused with:
- Piracetam
Dosage information
To supplement Noopept, take 10 – 30 mg, once a day, for up to 56 days at a time. More research is needed to determine the optimal human dose for Noopept.
Frequently asked questions
What is N-phenylacetyl-L-prolylglycine ethyl ester (Noopept)?
N-phenylacetyl-L-prolylglycine ethyl ester, or Noopept, is a synthetic pharmaceutical designed by a Russian pharmaceutical company. It is sometimes called a nootropic, based on preliminary evidence that it has neuroprotective and cognitive enhancing properties.[1][2][3] Noopept was designed using the structure of piracetam, another nootropic, as a starting point.[4]
What are Noopept’s main benefits?
Noopept may support brain health, primarily based on studies in rodents with brain damage, and one small human trial indicated that it could improve cognitive function in participants with mild cognitive impairment from a stroke. However, these findings have not been independently replicated.
Noopept may be beneficial for brain health, but this claim is based almost exclusively on studies in which Noopept was administered (often via injection) to rodents with brain damage caused by toxin injection, oxygen deprivation, and other methods.[5][6][7][8][ One of the only controlled trials involving humans found that Noopept supplementation improved cognitive function in a small group of people with mild cognitive impairment (MCI) resulting from a stroke.[9] These findings have not yet been independently replicated.
What are Noopept’s main drawbacks?
Noopept may cause sleep disturbances, irritability, and increased blood pressure, and there is limited research on its safety. Additionally, it could potentially lead to dizziness, headaches, gastrointestinal issues, and memory impairments, although these effects are not well-established.
Sleep disturbances, irritability, and increases in blood pressure have been reported in people taking Noopept.[10][9] It should be stressed that there is not much research evaluating the safety of Noopept.
Given its similarities to other nootropics like piracetam and ampakines, Noopept may also cause dizziness, headaches, gastrointestinal symptoms, and impairments in memory, although these effects are speculative.[11]
How does Noopept work?
Noopept's mechanism of action is not fully understood, but it may increase levels of brain-derived neurotrophic factor and activate neurotransmitter receptors related to learning and cognitive function. This includes modulation of glutamatergic and cholinergic receptors.
Noopept’s mechanism of action is uncertain, but several possibilities have been proposed. In particular, it may increase levels of brain-derived neurotrophic factor (BDNF), a protein that helps establish neural connections and neurotransmission in the brain.[12] Noopept may also activate or modulate neurotransmitter receptors involved in learning and cognitive function, including certain glutamatergic and cholinergic receptors.[13][14][3]
Research Breakdown
References
Examine Database References
- Cerebral Trauma Rehabilitation - Neznamov GG, Teleshova ESComparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic originNeurosci Behav Physiol.(2009 Mar)
