Higher intakes of dietary fiber are associated with a reduced risk of colorectal cancer,[1][2][3] but it is unclear whether RS has a similar effect.
Some in vitro study and animal studies have suggested that RS could have a beneficial effect on colorectal cancer prevention (particularly related to butyrate production),[4] but clinical trials to date have not found any beneficial effect.[5][6] Interestingly, preliminary research suggests that RS supplementation might offset some of the potentially negative effects of red meat consumption on colorectal health. One study found that RS (40 g/day) supplemented alongside a high-red-meat diet (300 g/day) increased fecal levels of SCFAs and reduced the formation of DNA adducts in rectal tissue cells, compared to the high red meat diet alone. DNA adducts occur when a potentially cancer-causing compound (as can be found in some red meats or produced through their bacterial fermentation) binds to cellular DNA, which could induce cell mutations leading to cancer.[7]
Ultimately, clinical trials with larger sample sizes and longer durations will be required to better understand the relationship between RS and colorectal cancer prevention.
References
- ^Ma Y, Hu M, Zhou L, Ling S, Li Y, Kong B, Huang PDietary fiber intake and risks of proximal and distal colon cancers: A meta-analysis.Medicine (Baltimore).(2018 Sep)
- ^Gianfredi V, Salvatori T, Villarini M, Moretti M, Nucci D, Realdon SIs dietary fibre truly protective against colon cancer? A systematic review and meta-analysis.Int J Food Sci Nutr.(2018-Dec)
- ^Jun S, Lee J, Kim JAssociation of Dietary Fiber Intake With Gastrointestinal Tract Cancer Among Korean Adults.JAMA Netw Open.(2023-Mar-01)
- ^Malcomson FC, Willis ND, Mathers JCIs resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway?Proc Nutr Soc.(2015-Aug)
- ^Mathers JC, Movahedi M, Macrae F, Mecklin JP, Moeslein G, Olschwang S, Eccles D, Evans G, Maher ER, Bertario L, Bisgaard ML, Dunlop M, Ho JW, Hodgson S, Lindblom A, Lubinski J, Morrison PJ, Murday V, Ramesar R, Side L, Scott RJ, Thomas HJ, Vasen H, Gerdes AM, Barker G, Crawford G, Elliott F, Pylvanainen K, Wijnen J, Fodde R, Lynch H, Bishop DT, Burn J,Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial.Lancet Oncol.(2012-Dec)
- ^Burn J, Bishop DT, Chapman PD, Elliott F, Bertario L, Dunlop MG, Eccles D, Ellis A, Evans DG, Fodde R, Maher ER, Möslein G, Vasen HF, Coaker J, Phillips RK, Bülow S, Mathers JC,A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis.Cancer Prev Res (Phila).(2011-May)
- ^Le Leu RK, Winter JM, Christophersen CT, Young GP, Humphreys KJ, Hu Y, Gratz SW, Miller RB, Topping DL, Bird AR, Conlon MAButyrylated starch intake can prevent red meat-induced O6-methyl-2-deoxyguanosine adducts in human rectal tissue: a randomised clinical trial.Br J Nutr.(2015-Jul)