Frailty

    Written by:

    Fact-checked

    by:

    Last Updated: March 27, 2025

    Frailty is a clinical syndrome characterized by an age-associated decline in strength, muscle mass (sarcopenia), and physical reserve that increases the risk for falls, disability, hospitalization, and death.

    Overview

    Examine Database: Frailty

    Research FeedRead all studies

    Frequently asked questions

    Examine Database References

    1. Cognitive Decline - Muller M, van den Beld AW, van der Schouw YT, Grobbee DE, Lamberts SWEffects of dehydroepiandrosterone and atamestane supplementation on frailty in elderly menJ Clin Endocrinol Metab.(2006 Oct)
    2. Estrogen - Kenny AM, Boxer RS, Kleppinger A, Brindisi J, Feinn R, Burleson JADehydroepiandrosterone combined with exercise improves muscle strength and physical function in frail older womenJ Am Geriatr Soc.(2010 Sep)
    3. Muscle Mass - Nasimi N, Sohrabi Z, Nunes EA, Sadeghi E, Jamshidi S, Gholami Z, Akbarzadeh M, Faghih S, Akhlaghi M, Phillips SMWhey Protein Supplementation with or without Vitamin D on Sarcopenia-Related Measures: A Systematic Review and Meta-Analysis.Adv Nutr.(2023-Jul)
    4. Muscle Mass - Ezaki O, Abe SMedium-chain triglycerides (8:0 and 10:0) increase muscle mass and function in frail older adults: a combined data analysis of clinical trialsFront Nutr.(2023 Dec 4)
    5. Strength - Kojima K, Ishikawa H, Watanabe S, Nosaka N, Mutoh TA Randomized, Double-Blind, Controlled Trial Assessing If Medium-Chain Triglycerides in Combination with Moderate-Intensity Exercise Increase Muscle Strength in Healthy Middle-Aged and Older AdultsNutrients.(2023 Jul 24)
    6. Functionality in Elderly or Injured - Rodondi A, Ammann P, Ghilardi-Beuret S, Rizzoli RZinc increases the effects of essential amino acids-whey protein supplements in frail elderlyJ Nutr Health Aging.(2009 Jun)
    7. Fracture Risk - Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, Thoma A, Kiel DP, Henschkowski JPrevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trialsArch Intern Med.(2009 Mar 23)