What role might H. pylori infection play in other diseases?

    Last Updated: October 13, 2024

    People with H. pylori infections are more likely to have or develop hypertension, non-alcoholic fatty liver disease, and subclinical atherosclerosis. It may also increase the risk of developing irritable bowel syndrome (IBS), but more research is needed to confirm this association.[1][2][3][4][5]

    H. pylori treatment may help to reduce IBS symptoms and is also associated with a reduced risk of gastric cancer. Some research shows that eradication therapy could increase the risk of developing gastroesophageal reflux disease, but other research suggests it has no effect.[5][6]

    References

    1. ^Fang Y, Xie H, Fan CAssociation of hypertension with helicobacter pylori: A systematic review and meta‑analysis.PLoS One.(2022)
    2. ^Heydari K, Yousefi M, Alizadeh-Navaei R, Lotfi P, Sheydaee F, Raei M, Vahdatinia A, Hessami A, Rafati S, Moosazadeh M, Ghasemian R, Salehi F, Massoudi H, Ghaffari-Saravi F, Rismantab SHelicobacter pylori Infection and Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.Turk J Gastroenterol.(2022-03)
    3. ^Wang X, He Q, Jin D, Ma B, Yao K, Zou XAssociation between helicobacter pylori infection and subclinical atherosclerosis: A systematic review and meta-analysis.Medicine (Baltimore).(2021-Nov-19)
    4. ^Chenyu Li, Yujun Shuai, Xiaodong Zhou, Hongxia ChenAssociation between Helicobacter pylori infection and irritable bowel syndrome: A systematic review and meta-analysisMedicine (Baltimore).(2020 Dec 11)
    5. ^Xiong Y, Liu L, Zhou X, Wen Y, Wang RAnti-Helicobacter pylori treatment can effectively improve the clinical remission rates of irritable bowel syndrome: a controlled clinical trial meta-analysis.Clinics (Sao Paulo).(2020)
    6. ^Zhao Y, Li Y, Hu J, Wang X, Ren M, Lu G, Lu X, Zhang D, He SThe Effect of Helicobacter pylori Eradication in Patients with Gastroesophageal Reflux Disease: A Meta-Analysis of Randomized Controlled Studies.Dig Dis.(2020)