Despite the high demand and potential productivity-saving applications of hangover treatments, there is currently a lack of evidence to support any such remedies. Though several different supplements and herbal compounds have been studied for their ability to reduce hangover symptoms, most have very little research to support their efficacy. A systematic review published in 2022 concluded that some supplements may reduce hangover symptoms compared to placebo. These include clove extract, pyritinol (a chemically-altered vitamin B6), Hovenia dulcis fruit extract, L-cysteine, red ginseng, and Korean pear juice. However, the evidence to support any of these supplements was rated as very low quality[1], mostly due to a lack of well-controlled studies.