Vitamin B6
•Last Updated: September 28 2022
Vitamin B6 is one of the B-vitamins, used in producing a necessary coenzyme in the body. While essential and with many small benefits, there appear to be no highly effective unique reasons to use this supplement.
Vitamin B6 is most often used for
Last Updated: September 28 2022
Note that Vitamin B6 is also known as:
- pyridoxine
- pyridoxamine
- pyridoxal
- pyridoxal phosphate
- pyridoxal-5'-phosphate
- PLP
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Recent evidence has linked B vitamins (specifically B6 and B12) to an increased risk of lung cancer in men, especially in smokers. Here, we analyze the study and interview the lead author, Dr. Theodore Brasky.
B vitamins are common ingredients of multivitamins, of course, but also of energy boosters, such as energy drinks. But while they are best known for their role in energy metabolism,[60] they may play a role in cancer biology through partaking in one-carbon metabolism[61] and thus in methylation reactions and DNA synthesis.
This hypothesis was substantiated in 2015 when a paper published by the New England Journal of Medicine caused a stir by reporting that nicotinamide (a form of vitamin B3 also known as niacinamide) could reduce the rate of new non-melanoma skin cancers...
1.^Clayton PTB6-responsive disorders: a model of vitamin dependencyJ Inherit Metab Dis.(2006 Apr-Jun)
2.^Allgood VE1, Cidlowski JAVitamin B6 modulates transcriptional activation by multiple members of the steroid hormone receptor superfamilyJ Biol Chem.(1992 Feb 25)
3.^Zhang SM1, Willett WC, Selhub J, Hunter DJ, Giovannucci EL, Holmes MD, Colditz GA, Hankinson SEPlasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancerJ Natl Cancer Inst.(2003 Mar 5)
4.^Wei EK1, Giovannucci E, Selhub J, Fuchs CS, Hankinson SE, Ma JPlasma vitamin B6 and the risk of colorectal cancer and adenoma in womenJ Natl Cancer Inst.(2005 May 4)
6.^Bidoli E1, Bosetti C, La Vecchia C, Levi F, Parpinel M, Talamini R, Negri E, Maso LD, Franceschi SMicronutrients and laryngeal cancer risk in Italy and Switzerland: a case-control studyCancer Causes Control.(2003 Jun)
8.^Albersen M1, Bosma M, Knoers NV, de Ruiter BH, Diekman EF, de Ruijter J, Visser WF, de Koning TJ, Verhoeven-Duif NMThe intestine plays a substantial role in human vitamin B6 metabolism: a Caco-2 cell modelPLoS One.(2013)
9.^Fonda ML1, Trauss C, Guempel UMThe binding of pyridoxal 5'-phosphate to human serum albuminArch Biochem Biophys.(1991 Jul)
11.^Ngo EO1, LePage GR, Thanassi JW, Meisler N, Nutter LMAbsence of pyridoxine-5'-phosphate oxidase (PNPO) activity in neoplastic cells: isolation, characterization, and expression of PNPO cDNABiochemistry.(1998 May 26)
12.^Jang YM1, Kim DW, Kang TC, Won MH, Baek NI, Moon BJ, Choi SY, Kwon OSHuman pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distributionJ Biol Chem.(2003 Dec 12)
13.^Middleton HM 3rdUptake of pyridoxine hydrochloride by the rat jejunal mucosa in vitroJ Nutr.(1977 Jan)
14.^BOOTH CC, BRAIN MCThe absorption of tritium-labelled pyridoxine hydrochloride in the ratJ Physiol.(1962 Nov)
15.^Mehansho H, Hamm MW, Henderson LMTransport and metabolism of pyridoxal and pyridoxal phosphate in the small intestine of the ratJ Nutr.(1979 Sep)
16.^Hamm MW, Mehansho H, Henderson LMTransport and metabolism of pyridoxamine and pyridoxamine phosphate in the small intestine of the ratJ Nutr.(1979 Sep)
17.^Said HM1, Ortiz A, Ma TYA carrier-mediated mechanism for pyridoxine uptake by human intestinal epithelial Caco-2 cells: regulation by a PKA-mediated pathwayAm J Physiol Cell Physiol.(2003 Nov)
18.^Said ZM1, Subramanian VS, Vaziri ND, Said HMPyridoxine uptake by colonocytes: a specific and regulated carrier-mediated processAm J Physiol Cell Physiol.(2008 May)
19.^Nguyen LB, Gregory JF 3rd, Cerda JJEffect of dietary fiber on absorption of B-6 vitamers in a rat jejunal perfusion studyProc Soc Exp Biol Med.(1983 Sep)
20.^Nelson EW Jr, Lane H, Cerda JJComparative human intestinal bioavailability of vitamin B-6 from a synthetic and a natural sourceJ Nutr.(1976 Oct)
21.^Mappouras DG1, Stiakakis J, Fragoulis EGPurification and characterization of L-dopa decarboxylase from human kidneyMol Cell Biochem.(1990 May 10)
22.^Delitala G, Masala A, Alagna S, Devilla LEffect of pyridoxine on human hypophyseal trophic hormone release: a possible stimulation of hypothalamic dopaminergic pathwayJ Clin Endocrinol Metab.(1976 Mar)
23.^Allen GF1, Neergheen V, Oppenheim M, Fitzgerald JC, Footitt E, Hyland K, Clayton PT, Land JM, Heales SJPyridoxal 5'-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells, implications for aromatic L-amino acid decarboxylase and vitamin B(6) deficiency statesJ Neurochem.(2010 Jul)
24.^Sharma SK1, Dakshinamurti KEffects of serotonergic agents on plasma prolactin levels in pyridoxine-deficient adult male ratsNeurochem Res.(1994 Jun)
25.^Pace-Schott EF1, Gersh T, Silvestri R, Stickgold R, Salzman C, Hobson JASSRI treatment suppresses dream recall frequency but increases subjective dream intensity in normal subjectsJ Sleep Res.(2001 Jun)
26.^Ebben M1, Lequerica A, Spielman AEffects of pyridoxine on dreaming: a preliminary studyPercept Mot Skills.(2002 Feb)
27.^Zemel MB1, Bruckbauer AEffects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjectsNutrients.(2012 Jun)
28.^Dakshinamurti K1, Lal KJ, Ganguly PKHypertension, calcium channel and pyridoxine (vitamin B6)Mol Cell Biochem.(1998 Nov)
29.^Villarroel P1, Reyes M, Fuentes C, Segovia MP, Tobar N, Villalobos E, Martínez J, Hugo E, Ben-Jonathan N, Cifuentes MAdipogenic effect of calcium sensing receptor activationMol Cell Biochem.(2013 Dec)
30.^He YH1, He Y, Liao XL, Niu YC, Wang G, Zhao C, Wang L, Tian MJ, Li Y, Sun CHThe calcium-sensing receptor promotes adipocyte differentiation and adipogenesis through PPARγ pathwayMol Cell Biochem.(2012 Feb)
31.^Allgood VE1, Powell-Oliver FE, Cidlowski JAThe influence of vitamin B6 on the structure and function of the glucocorticoid receptorAnn N Y Acad Sci.(1990)
32.^Allgood VE1, Powell-Oliver FE, Cidlowski JAVitamin B6 influences glucocorticoid receptor-dependent gene expressionJ Biol Chem.(1990 Jul 25)
33.^Allgood VE1, Oakley RH, Cidlowski JAModulation by vitamin B6 of glucocorticoid receptor-mediated gene expression requires transcription factors in addition to the glucocorticoid receptorJ Biol Chem.(1993 Oct 5)
34.^Barletta C, Sellini M, Bartoli A, Bigi C, Buzzetti R, Giovannini CInfluence of administration of pyridoxine on circadian rhythm of plasma ACTH, cortisol prolactin and somatotropin in normal subjectsBoll Soc Ital Biol Sper.(1984 Feb 28)
35.^Ren SG1, Melmed SPyridoxal phosphate inhibits pituitary cell proliferation and hormone secretionEndocrinology.(2006 Aug)
36.^Moretti C, Fabbri A, Gnessi L, Bonifacio V, Fraioli F, Isidori APyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exerciseN Engl J Med.(1982 Aug 12)
37.^Rosenberg JM, Lau-Cam CA, McGuire HEffects of pyridoxine hydrochloride (vitamin B6) on chlorpromazine-induced serum prolactin rise in male ratsJ Pharm Sci.(1979 Sep)
38.^Vescovi PP, Gerra G, Rastelli G, Ceresini G, Moccia GPyridoxine (Vit. B6) decreases opioids-induced hyperprolactinemiaHorm Metab Res.(1985 Jan)
39.^Lurie G1, Wilkens LR, Shvetsov YB, Ollberding NJ, Franke AA, Henderson BE, Kolonel LN, Goodman MTPrediagnostic plasma pyridoxal 5'-phosphate (vitamin b6) levels and invasive breast carcinoma risk: the multiethnic cohortCancer Epidemiol Biomarkers Prev.(2012 Nov)
40.^Gressett SM1, Stanford BL, Hardwicke FManagement of hand-foot syndrome induced by capecitabineJ Oncol Pharm Pract.(2006 Sep)
41.^Vukelja SJ, Lombardo FA, James WD, Weiss RBPyridoxine for the palmar-plantar erythrodysesthesia syndromeAnn Intern Med.(1989 Oct 15)
42.^Fabian CJ1, Molina R, Slavik M, Dahlberg S, Giri S, Stephens RPyridoxine therapy for palmar-plantar erythrodysesthesia associated with continuous 5-fluorouracil infusionInvest New Drugs.(1990 Feb)
43.^Corrie PG1, Bulusu R, Wilson CB, Armstrong G, Bond S, Hardy R, Lao-Sirieix S, Parashar D, Ahmad A, Daniel F, Hill M, Wilson G, Blesing C, Moody AM, McAdam K, Osborne MA randomised study evaluating the use of pyridoxine to avoid capecitabine dose modificationsBr J Cancer.(2012 Aug 7)
44.^Chang HY1, Tang FY, Chen DY, Chih HM, Huang ST, Cheng HD, Lan JL, Chiang EPClinical use of cyclooxygenase inhibitors impairs vitamin B-6 metabolismAm J Clin Nutr.(2013 Dec)
45.^Stamatiadis D, Bulteau-Portois MC, Mowszowicz IInhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acidBr J Dermatol.(1988 Nov)
46.^Netter A, Hartoma R, Nahoul KEffect of zinc administration on plasma testosterone, dihydrotestosterone, and sperm countArch Androl.(1981 Aug)
47.^Leake A, Chisholm GD, Habib FKThe effect of zinc on the 5 alpha-reduction of testosterone by the hyperplastic human prostate glandJ Steroid Biochem.(1984 Feb)
48.^Schaumburg H, Kaplan J, Windebank A, Vick N, Rasmus S, Pleasure D, Brown MJSensory neuropathy from pyridoxine abuse. A new megavitamin syndromeN Engl J Med.(1983 Aug 25)
49.^Foca FJMotor and sensory neuropathy secondary to excessive pyridoxine ingestionArch Phys Med Rehabil.(1985 Sep)
50.^Dalton K, Dalton MJCharacteristics of pyridoxine overdose neuropathy syndromeActa Neurol Scand.(1987 Jul)
52.^Montpetit VJ1, Clapin DF, Tryphonas L, Dancea SAlteration of neuronal cytoskeletal organization in dorsal root ganglia associated with pyridoxine neurotoxicityActa Neuropathol.(1988)
53.^Krinke G1, Schaumburg HH, Spencer PS, Suter J, Thomann P, Hess RPyridoxine megavitaminosis produces degeneration of peripheral sensory neurons (sensory neuronopathy) in the dogNeurotoxicology.(1981 Jan)
54.^Hoover DM, Carlton WW, Henrikson CKUltrastructural lesions of pyridoxine toxicity in beagle dogsVet Pathol.(1981 Nov)
55.^Windebank AJ, Low PA, Blexrud MD, Schmelzer JD, Schaumburg HHPyridoxine neuropathy in rats: specific degeneration of sensory axonsNeurology.(1985 Nov)
56.^Krinke GJ1, Fitzgerald REThe pattern of pyridoxine-induced lesion: difference between the high and the low toxic levelToxicology.(1988 Apr)
57.^Xu Y1, Sladky JT, Brown MJDose-dependent expression of neuronopathy after experimental pyridoxine intoxicationNeurology.(1989 Aug)
58.^Krinke G, Naylor DC, Skorpil VPyridoxine megavitaminosis: an analysis of the early changes induced with massive doses of vitamin B6 in rat primary sensory neuronsJ Neuropathol Exp Neurol.(1985 Mar)
59.^Perry TA1, Weerasuriya A, Mouton PR, Holloway HW, Greig NHPyridoxine-induced toxicity in rats: a stereological quantification of the sensory neuropathyExp Neurol.(2004 Nov)
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