Have any supplements been studied for hyperemesis gravidarum?

    Last Updated: October 25, 2023

    The vomiting associated with hyperemesis gravidarum can result in the depletion of important vitamins, including thiamine (vitamin B1) and vitamin K, which can lead to further neurological and cardiovascular complications.[1] Repletion of these vitamins will generally be included in standard medical care, but supplementation may also be recommended to maintain adequate levels.

    As in all pregnancies, supplementation with a prenatal vitamin is recommended to ensure baseline vitamin and mineral requirements are being met. Certain vitamins and minerals can also be administered intramuscularly or intravenously if nausea and vomiting prevent oral intake.

    Pyridoxine (vitamin B6) and ginger are effective for treating mild to moderate nausea and vomiting in pregnancy, but they have not been found to be effective for the severe nausea and vomiting of hyperemesis gravidarum.[2][3]

    References

    1. ^Popa SL, Barsan M, Caziuc A, Pop C, Muresan L, Popa LC, Perju-Dumbrava LLife-threatening complications of hyperemesis gravidarum.Exp Ther Med.(2021-Jun)
    2. ^Boelig RC, Barton SJ, Saccone G, Kelly AJ, Edwards SJ, Berghella VInterventions for treating hyperemesis gravidarum: a Cochrane systematic review and meta-analysis.J Matern Fetal Neonatal Med.(2018-Sep)
    3. ^McParlin C, O'Donnell A, Robson SC, Beyer F, Moloney E, Bryant A, Bradley J, Muirhead CR, Nelson-Piercy C, Newbury-Birch D, Norman J, Shaw C, Simpson E, Swallow B, Yates L, Vale LTreatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review.JAMA.(2016-Oct-04)