Vitamin K

Last Updated: September 28 2022

Vitamin K is an essential vitamin found in plants or produced from intestinal bacteria. It plays an essential role in bone health and regulates blood clotting.

Vitamin K is most often used for

Summary

Vitamin K is an essential vitamin. It is one of the four fat-soluble vitamins, along with vitamin A, vitamin D, and vitamin E. It was named vitamin K after the German word koagulation, because vitamin K’s role in blood coagulation was first discovered in Germany. Vitamin K can be found in dark green vegetables, matcha tea, and natto (a type of fermented soybeans). Vitamin K can also be found in various animal products.

The Recommended Daily Intake (RDI) of vitamin K is sufficient to support healthy blood coagulation. Higher levels of vitamin K, however, may provide additional benefits. Unfortunately, it can be difficult to obtain high levels of vitamin K from food alone. Most people don’t like natto enough to eat 50g a day, so supplementation of vitamin K is a popular option.

Vitamin K has at times been found to improve markers of bone health. Despite this, supplementation has inconsistent effects on bone fracture risk.

Vitamin K has been suggested to protect cardiovascular health by reducing the calcification and stiffening of arteries. However, a number of clinical trials have found no apparent effect of vitamin K supplementation on arterial calcification. Most of these trials were on people with extensive arterial calcification already present, meaning additional research is needed to determine if vitamin K can prevent tissue calcification before it has started.

Vitamin K may have a role to play in cancer therapy. It may also help with regulating insulin sensitivity and (in topical form) may help reduce skin reddening, but more research is needed before strong conclusions can be drawn.

Vitamin K’s main mechanism is through the vitamin K cycle, which is a cyclical metabolic pathway that uses vitamin K to modify various proteins. Specifically, vitamin K is used to attach a carbon dioxide molecule onto a glutamate contained in these proteins, allowing the protein to bind calcium ions. These proteins can then utilize calcium ions for various biological processes.

Vitamin K is often supplemented alongside vitamin D, since vitamin D also supports bone health. In fact, taking both together may improve the effects of each, since they are believed to work synergistically. Excessive vitamin D can lead to arterial calcification and in animal models vitamin K reduces this buildup.

What else is Vitamin K known as?
Note that Vitamin K is also known as:
  • Phylloquinone
  • Menaquinone
  • MK-4
  • MK-7
  • Menatetrenone
  • Phytonadione
Vitamin K should not be confused with:
Dosage information

Vitamin K comes in a variety of different forms, known as vitamers. Forms of vitamin K are either phylloquinones (vitamin K1) or menaquinones (vitamin K2). There are different vitamers within the vitamin K2 class, abbreviated as MK-x.

The minimum effective dose for phylloquinone (vitamin K1) is 50mcg, which is enough to satisfy the Recommended Daily Intake (RDI) for vitamin K. The maximum dose for vitamin K1 is 10,000mcg (10 mg).

The minimum effective dose for short chain menaquinones (MK-4) is 1,500mcg. Doses of up to 45mg (45,000mcg) have been safely used in a superloading dosing protocol.

The minimum effective dose for longer chain menaquinones (MK-7, MK-8, and MK-9) is between 90-360mcg. Further research is needed to determine the maximum effective dose for MK-7.

A topical application of vitamin K should contain at least 5% phylloquinone.

Vitamin K should be supplemented alongside fatty acids, even if the vitamin is coming from a plant-based source, so consider taking vitamin K at meal time. Microwaving plant-based sources of vitamin K will increase the absorption rate of the vitamin.

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      References
      9.^Kamao M, Suhara Y, Tsugawa N, Uwano M, Yamaguchi N, Uenishi K, Ishida H, Sasaki S, Okano TVitamin K content of foods and dietary vitamin K intake in Japanese young womenJ Nutr Sci Vitaminol (Tokyo).(2007 Dec)
      11.^Sato T, Schurgers LJ, Uenishi KComparison of menaquinone-4 and menaquinone-7 bioavailability in healthy womenNutr J.(2012 Nov 12)
      12.^Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JCDietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam StudyJ Nutr.(2004 Nov)
      14.^Mummah-Schendel LL, Suttie JWSerum phylloquinone concentrations in a normal adult populationAm J Clin Nutr.(1986 Nov)
      15.^Novotny JA, Kurilich AC, Britz SJ, Baer DJ, Clevidence BAVitamin K absorption and kinetics in human subjects after consumption of 13C-labelled phylloquinone from kaleBr J Nutr.(2010 Sep)
      16.^Garber AK, Binkley NC, Krueger DC, Suttie JWComparison of phylloquinone bioavailability from food sources or a supplement in human subjectsJ Nutr.(1999 Jun)
      17.^Jones KS, Bluck LJ, Wang LY, Stephen AM, Prynne CJ, Coward WAThe effect of different meals on the absorption of stable isotope-labelled phylloquinoneBr J Nutr.(2009 Oct)
      19.^Shea MK, Benjamin EJ, Dupuis J, Massaro JM, Jacques PF, D'Agostino RB Sr, Ordovas JM, O'Donnell CJ, Dawson-Hughes B, Vasan RS, Booth SLGenetic and non-genetic correlates of vitamins K and DEur J Clin Nutr.(2009 Apr)
      20.^Booth SL, Al Rajabi ADeterminants of vitamin K status in humansVitam Horm.(2008)
      22.^Bolling BW, McKay DL, Blumberg JBThe phytochemical composition and antioxidant actions of tree nutsAsia Pac J Clin Nutr.(2010)
      23.^Sakamaki N, Nakazato M, Matsumoto H, Hagino K, Yasuda K, Nagayama TDetermination of vitamin K in aojiru (green juice) products by HPLCShokuhin Eiseigaku Zasshi.(2006 Apr)
      24.^Bolton-Smith C, Price RJ, Fenton ST, Harrington DJ, Shearer MJCompilation of a provisional UK database for the phylloquinone (vitamin K1) content of foodsBr J Nutr.(2000 Apr)
      26.^Lippi G, Salvagno GL, Montagnana M, Guidi GCComment on effects of microwave cooking conditions on bioactive compounds present in broccoli inflorescencesJ Agric Food Chem.(2008 Mar 26)
      27.^Homma K, Wakana N, Suzuki Y, Nukui M, Daimatsu T, Tanaka E, Tanaka K, Koga Y, Nakajima Y, Nakazawa HTreatment of natto, a fermented soybean preparation, to prevent excessive plasma vitamin K concentrations in patients taking warfarinJ Nutr Sci Vitaminol (Tokyo).(2006 Oct)
      32.^Burnier JP, Borowski M, Furie BC, Furie BGamma-carboxyglutamic acidMol Cell Biochem.(1981 Sep 25)
      33.^Dowd P, Hershline R, Ham SW, Naganathan SMechanism of action of vitamin KNat Prod Rep.(1994 Jun)
      34.^Oldenburg J, Marinova M, Müller-Reible C, Watzka MThe vitamin K cycleVitam Horm.(2008)
      44.^Hauschka PV, Lian JB, Cole DE, Gundberg CMOsteocalcin and matrix Gla protein: vitamin K-dependent proteins in bonePhysiol Rev.(1989 Jul)
      45.^Theuwissen E, Smit E, Vermeer CThe role of vitamin K in soft-tissue calcificationAdv Nutr.(2012 Mar 1)
      46.^Neve A, Corrado A, Cantatore FPOsteocalcin: skeletal and extra-skeletal effectsJ Cell Physiol.(2013 Jun)
      48.^Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty GEndocrine regulation of energy metabolism by the skeletonCell.(2007 Aug 10)
      49.^Binkley NC, Krueger DC, Kawahara TN, Engelke JA, Chappell RJ, Suttie JWA high phylloquinone intake is required to achieve maximal osteocalcin gamma-carboxylationAm J Clin Nutr.(2002 Nov)
      50.^Dalmeijer GW, van der Schouw YT, Magdeleyns E, Ahmed N, Vermeer C, Beulens JWThe effect of menaquinone-7 supplementation on circulating species of matrix Gla proteinAtherosclerosis.(2012 Dec)
      51.^Booth SL, Martini L, Peterson JW, Saltzman E, Dallal GE, Wood RJDietary phylloquinone depletion and repletion in older womenJ Nutr.(2003 Aug)
      54.^Schafer C, Heiss A, Schwarz A, Westenfeld R, Ketteler M, Floege J, Muller-Esterl W, Schinke T, Jahnen-Dechent WThe serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcificationJ Clin Invest.(2003 Aug)
      55.^Viegas CS, Simes DC, Laizé V, Williamson MK, Price PA, Cancela MLGla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebratesJ Biol Chem.(2008 Dec 26)
      56.^Hepner M, Karlaftis VProtein SMethods Mol Biol.(2013)
      57.^Li J, Lin JC, Wang H, Peterson JW, Furie BC, Furie B, Booth SL, Volpe JJ, Rosenberg PANovel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neuronsJ Neurosci.(2003 Jul 2)
      58.^Hepner M, Karlaftis VProtein CMethods Mol Biol.(2013)
      60.^Nakano T, Ishimoto Y, Kishino J, Umeda M, Inoue K, Nagata K, Ohashi K, Mizuno K, Arita HCell adhesion to phosphatidylserine mediated by a product of growth arrest-specific gene 6J Biol Chem.(1997 Nov 21)
      61.^Varnum BC, Young C, Elliott G, Garcia A, Bartley TD, Fridell YW, Hunt RW, Trail G, Clogston C, Toso RJ, et alAxl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6Nature.(1995 Feb 16)
      65.^Coutu DL, Wu JH, Monette A, Rivard GE, Blostein MD, Galipeau JPeriostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cellsJ Biol Chem.(2008 Jun 27)
      66.^Shiraishi H, Masuoka M, Ohta S, Suzuki S, Arima K, Taniguchi K, Aoki S, Toda S, Yoshimoto T, Inagaki N, Conway SJ, Narisawa Y, Izuhara KPeriostin contributes to the pathogenesis of atopic dermatitis by inducing TSLP production from keratinocytesAllergol Int.(2012 Dec)
      67.^Masuoka M, Shiraishi H, Ohta S, Suzuki S, Arima K, Aoki S, Toda S, Inagaki N, Kurihara Y, Hayashida S, Takeuchi S, Koike K, Ono J, Noshiro H, Furue M, Conway SJ, Narisawa Y, Izuhara KPeriostin promotes chronic allergic inflammation in response to Th2 cytokinesJ Clin Invest.(2012 Jul 2)
      68.^Romanos GE, Asnani KP, Hingorani D, Deshmukh VLPeriostin: Role in formation and maintenance of dental tissuesJ Cell Physiol.(2013 May 23)
      71.^Taira H, Fujikawa Y, Kudo O, Itonaga I, Torisu TMenatetrenone (vitamin K2) acts directly on circulating human osteoclast precursorsCalcif Tissue Int.(2003 Jul)
      72.^Kameda T, Miyazawa K, Mori Y, Yuasa T, Shiokawa M, Nakamaru Y, Mano H, Hakeda Y, Kameda A, Kumegawa MVitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosisBiochem Biophys Res Commun.(1996 Mar 27)
      75.^Denisova NA, Booth SLVitamin K and sphingolipid metabolism: evidence to dateNutr Rev.(2005 Apr)
      76.^Tabb MM, Sun A, Zhou C, Grün F, Errandi J, Romero K, Pham H, Inoue S, Mallick S, Lin M, Forman BM, Blumberg BVitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXRJ Biol Chem.(2003 Nov 7)
      77.^Igarashi M, Yogiashi Y, Mihara M, Takada I, Kitagawa H, Kato SVitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 geneMol Cell Biol.(2007 Nov)
      78.^Frick PG, Riedler G, Brögli HDose response and minimal daily requirement for vitamin K in manJ Appl Physiol.(1967 Sep)
      79.^Suttie JW, Mummah-Schendel LL, Shah DV, Lyle BJ, Greger JLVitamin K deficiency from dietary vitamin K restriction in humansAm J Clin Nutr.(1988 Mar)
      83.^Matthys C, Bucchini L, Busstra MC, Cavelaars AE, Eleftheriou P, Garcia-Alvarez A, Fairweather-Tait S, Gurinović M, van Ommen B, Contor LEURRECA: development of tools to improve the alignment of micronutrient recommendationsEur J Clin Nutr.(2010 Nov)
      85.^Knapen MH, Jie KS, Hamulyák K, Vermeer CVitamin K-induced changes in markers for osteoblast activity and urinary calcium lossCalcif Tissue Int.(1993 Aug)
      87.^Vergnaud P, Garnero P, Meunier PJ, Bréart G, Kamihagi K, Delmas PDUndercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS StudyJ Clin Endocrinol Metab.(1997 Mar)
      88.^Szulc P, Arlot M, Chapuy MC, Duboeuf F, Meunier PJ, Delmas PDSerum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly womenJ Bone Miner Res.(1994 Oct)
      89.^Szulc P, Chapuy MC, Meunier PJ, Delmas PDSerum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly womenJ Clin Invest.(1993 Apr)
      93.^Puckett RM, Offringa MProphylactic vitamin K for vitamin K deficiency bleeding in neonatesCochrane Database Syst Rev.(2000)
      94.^Cocchetto DM, Miller DB, Miller LL, Bjornsson TDBehavioral perturbations in the vitamin K-deficient ratPhysiol Behav.(1985 May)
      96.^Cranenburg EC, Koos R, Schurgers LJ, Magdeleyns EJ, Schoonbrood TH, Landewé RB, Brandenburg VM, Bekers O, Vermeer CCharacterisation and potential diagnostic value of circulating matrix Gla protein (MGP) speciesThromb Haemost.(2010 Oct)
      97.^Fusaro M, Noale M, Viola V, Galli F, Tripepi G, Vajente N, Plebani M, Zaninotto M, Guglielmi G, Miotto D, Dalle Carbonare L, D'Angelo A, Naso A, Grimaldi C, Miozzo D, Giannini S, Gallieni M; VItamin K Italian (VIKI) Dialysis Study InvestigatorsVitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis studyJ Bone Miner Res.(2012 Nov)
      98.^Westenfeld R, Krueger T, Schlieper G, Cranenburg EC, Magdeleyns EJ, Heidenreich S, Holzmann S, Vermeer C, Jahnen-Dechent W, Ketteler M, Floege J, Schurgers LJEffect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trialAm J Kidney Dis.(2012 Feb)
      99.^Hussaini SH, Ahmed S, Heatley RVCeliac disease and hypoprothrombinemiaNutrition.(1999 May)
      101.^Kuwabara A, Tanaka K, Tsugawa N, Nakase H, Tsuji H, Shide K, Kamao M, Chiba T, Inagaki N, Okano T, Kido SHigh prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel diseaseOsteoporos Int.(2009 Jun)
      102.^Iijima H, Shinzaki S, Takehara TThe importance of vitamins D and K for the bone health and immune function in inflammatory bowel diseaseCurr Opin Clin Nutr Metab Care.(2012 Nov)
      103.^Booth SLVitamin K status in the elderlyCurr Opin Clin Nutr Metab Care.(2007 Jan)
      104.^Presse N, Shatenstein B, Kergoat MJ, Ferland GLow vitamin K intakes in community-dwelling elders at an early stage of Alzheimer's diseaseJ Am Diet Assoc.(2008 Dec)
      105.^Misra D, Booth SL, Tolstykh I, Felson DT, Nevitt MC, Lewis CE, Torner J, Neogi TVitamin K deficiency is associated with incident knee osteoarthritisAm J Med.(2013 Mar)
      107.^Booth SL, Tucker KL, Chen H, Hannan MT, Gagnon DR, Cupples LA, Wilson PW, Ordovas J, Schaefer EJ, Dawson-Hughes B, Kiel DPDietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and womenAm J Clin Nutr.(2000 May)
      108.^Feskanich D, Weber P, Willett WC, Rockett H, Booth SL, Colditz GAVitamin K intake and hip fractures in women: a prospective studyAm J Clin Nutr.(1999 Jan)
      109.^Ueland T, Gullestad L, Dahl CP, Aukrust P, Aakhus S, Solberg OG, Vermeer C, Schurgers LJUndercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosisJ Intern Med.(2010 Nov)
      110.^Ueland T, Dahl CP, Gullestad L, Aakhus S, Broch K, Skårdal R, Vermeer C, Aukrust P, Schurgers LJCirculating levels of non-phosphorylated undercarboxylated matrix Gla protein are associated with disease severity in patients with chronic heart failureClin Sci (Lond).(2011 Aug)
      111.^Booth SL, Broe KE, Gagnon DR, Tucker KL, Hannan MT, McLean RR, Dawson-Hughes B, Wilson PW, Cupples LA, Kiel DPVitamin K intake and bone mineral density in women and menAm J Clin Nutr.(2003 Feb)
      112.^Caraballo PJ, Heit JA, Atkinson EJ, Silverstein MD, O'Fallon WM, Castro MR, Melton LJ 3rdLong-term use of oral anticoagulants and the risk of fractureArch Intern Med.(1999 Aug 9-23)
      113.^Caraballo PJ, Gabriel SE, Castro MR, Atkinson EJ, Melton LJ 3rdChanges in bone density after exposure to oral anticoagulants: a meta-analysisOsteoporos Int.(1999)
      114.^Jamal SA, Browner WS, Bauer DC, Cummings SRWarfarin use and risk for osteoporosis in elderly women. Study of Osteoporotic Fractures Research GroupAnn Intern Med.(1998 May 15)
      115.^Rosen HN, Maitland LA, Suttie JW, Manning WJ, Glynn RJ, Greenspan SLVitamin K and maintenance of skeletal integrity in adultsAm J Med.(1993 Jan)
      116.^Naraki T, Kohno N, Saito H, Fujimoto Y, Ohhira M, Morita T, Kohgo Ygamma-Carboxyglutamic acid content of hepatocellular carcinoma-associated des-gamma-carboxy prothrombinBiochim Biophys Acta.(2002 Apr 24)
      117.^Bach AU, Anderson SA, Foley AL, Williams EC, Suttie JWAssessment of vitamin K status in human subjects administered "minidose" warfarinAm J Clin Nutr.(1996 Dec)
      118.^Gundberg CM, Lian JB, Booth SLVitamin K-dependent carboxylation of osteocalcin: friend or foeAdv Nutr.(2012 Mar 1)
      123.^Ito A, Shirakawa H, Takumi N, Minegishi Y, Ohashi A, Howlader ZH, Ohsaki Y, Sato T, Goto T, Komai MMenaquinone-4 enhances testosterone production in rats and testis-derived tumor cellsLipids Health Dis.(2011 Sep 13)
      124.^Koitaya N, Sekiguchi M, Tousen Y, Nishide Y, Morita A, Yamauchi J, Gando Y, Miyachi M, Aoki M, Komatsu M, Watanabe F, Morishita K, Ishimi YLow-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese womenJ Bone Miner Metab.(2013 May 24)
      125.^Ozuru R, Sugimoto T, Yamaguchi T, Chihara KTime-dependent effects of vitamin K2 (menatetrenone) on bone metabolism in postmenopausal womenEndocr J.(2002 Jun)
      127.^Sell SStem cell origin of cancer and differentiation therapyCrit Rev Oncol Hematol.(2004 Jul)
      128.^Sakai I, Hashimoto S, Yoda M, Hida T, Ohsawa S, Nakajo S, Nakaya KNovel role of vitamin K2: a potent inducer of differentiation of various human myeloid leukemia cell linesBiochem Biophys Res Commun.(1994 Dec 15)
      129.^Booth SLRoles for vitamin K beyond coagulationAnnu Rev Nutr.(2009)
      130.^Shearer MJ, Newman PMetabolism and cell biology of vitamin KThromb Haemost.(2008 Oct)
      131.^Schurgers LJ, Teunissen KJ, Hamulyák K, Knapen MH, Vik H, Vermeer CVitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7Blood.(2007 Apr 15)
      132.^Theuwissen E, Cranenburg EC, Knapen MH, Magdeleyns EJ, Teunissen KJ, Schurgers LJ, Smit E, Vermeer CLow-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjectsBr J Nutr.(2012 Nov 14)
      133.^Brugè F, Bacchetti T, Principi F, Littarru GP, Tiano LOlive oil supplemented with menaquinone-7 significantly affects osteocalcin carboxylationBr J Nutr.(2011 Oct)
      134.^Groenen-van Dooren MM, Ronden JE, Soute BA, Vermeer CBioavailability of phylloquinone and menaquinones after oral and colorectal administration in vitamin K-deficient ratsBiochem Pharmacol.(1995 Sep 7)
      135.^Sato T, Ohtani Y, Yamada Y, Saitoh S, Harada HDifference in the metabolism of vitamin K between liver and bone in vitamin K-deficient ratsBr J Nutr.(2002 Apr)
      137.^Thijssen HH, Vervoort LM, Schurgers LJ, Shearer MJMenadione is a metabolite of oral vitamin KBr J Nutr.(2006 Feb)
      138.^Chawla D, Deorari AK, Saxena R, Paul VK, Agarwal R, Biswas A, Meena AVitamin K1 versus vitamin K3 for prevention of subclinical vitamin deficiency: a randomized controlled trialIndian Pediatr.(2007 Nov)
      141.^Shearer MJ, Barkhan P, Webster GRAbsorption and excretion of an oral dose of tritiated vitamin K1 in manBr J Haematol.(1970 Mar)
      143.^Koivu-Tikkanen TJ, Schurgers LJ, Thijssen HH, Vermeer CIntestinal, hepatic, and circulating vitamin K levels at low and high intakes of vitamin K in ratsBr J Nutr.(2000 Feb)
      144.^Gijsbers BL, Jie KS, Vermeer CEffect of food composition on vitamin K absorption in human volunteersBr J Nutr.(1996 Aug)
      145.^Booth SL, O'Brien-Morse ME, Dallal GE, Davidson KW, Gundberg CMResponse of vitamin K status to different intakes and sources of phylloquinone-rich foods: comparison of younger and older adultsAm J Clin Nutr.(1999 Sep)
      146.^Shearer MJ, McBurney A, Barkhan PStudies on the absorption and metabolism of phylloquinone (vitamin K1) in manVitam Horm.(1974)
      147.^Furt F, Oostende Cv, Widhalm JR, Dale MA, Wertz J, Basset GJA bimodular oxidoreductase mediates the specific reduction of phylloquinone (vitamin K₁) in chloroplastsPlant J.(2010 Oct)
      148.^Eugeni Piller L, Abraham M, Dörmann P, Kessler F, Besagni CPlastid lipid droplets at the crossroads of prenylquinone metabolismJ Exp Bot.(2012 Feb)
      149.^Schurgers LJ, Vermeer CDifferential lipoprotein transport pathways of K-vitamins in healthy subjectsBiochim Biophys Acta.(2002 Feb 15)
      150.^Cooper ADHepatic uptake of chylomicron remnantsJ Lipid Res.(1997 Nov)
      152.^Lamon-Fava S, Sadowski JA, Davidson KW, O'Brien ME, McNamara JR, Schaefer EJPlasma lipoproteins as carriers of phylloquinone (vitamin K1) in humansAm J Clin Nutr.(1998 Jun)
      153.^Erkkilä AT, Lichtenstein AH, Dolnikowski GG, Grusak MA, Jalbert SM, Aquino KA, Peterson JW, Booth SLPlasma transport of vitamin K in men using deuterium-labeled collard greensMetabolism.(2004 Feb)
      154.^Spronk HM, Soute BA, Schurgers LJ, Thijssen HH, De Mey JG, Vermeer CTissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated ratsJ Vasc Res.(2003 Nov-Dec)
      155.^Price PA, Faus SA, Williamson MKWarfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valvesArterioscler Thromb Vasc Biol.(1998 Sep)
      158.^Fu X, Peterson JW, Hdeib M, Booth SL, Grusak MA, Lichtenstein AH, Dolnikowski GGMeasurement of deuterium-labeled phylloquinone in plasma by high-performance liquid chromatography/mass spectrometryAnal Chem.(2009 Jul 1)
      160.^Niemeier A, Kassem M, Toedter K, Wendt D, Ruether W, Beisiegel U, Heeren JExpression of LRP1 by human osteoblasts: a mechanism for the delivery of lipoproteins and vitamin K1 to boneJ Bone Miner Res.(2005 Feb)
      161.^Weintraub MS, Eisenberg S, Breslow JLDietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein EJ Clin Invest.(1987 Dec)
      163.^Yan L, Zhou B, Nigdikar S, Wang X, Bennett J, Prentice AEffect of apolipoprotein E genotype on vitamin K status in healthy older adults from China and the UKBr J Nutr.(2005 Dec)
      164.^Pilkey RM, Morton AR, Boffa MB, Noordhof C, Day AG, Su Y, Miller LM, Koschinsky ML, Booth SLSubclinical vitamin K deficiency in hemodialysis patientsAm J Kidney Dis.(2007 Mar)
      166.^Hussain MM, Mahley RW, Boyles JK, Fainaru M, Brecht WJ, Lindquist PAChylomicron-chylomicron remnant clearance by liver and bone marrow in rabbits. Factors that modify tissue-specific uptakeJ Biol Chem.(1989 Jun 5)
      167.^Hussain MM, Goldberg IJ, Weisgraber KH, Mahley RW, Innerarity TLUptake of chylomicrons by the liver, but not by the bone marrow, is modulated by lipoprotein lipase activityArterioscler Thromb Vasc Biol.(1997 Jul)
      168.^Hussain MM, Mahley RW, Boyles JK, Lindquist PA, Brecht WJ, Innerarity TLChylomicron metabolism. Chylomicron uptake by bone marrow in different animal speciesJ Biol Chem.(1989 Oct 25)
      169.^Niemeier A, Niedzielska D, Secer R, Schilling A, Merkel M, Enrich C, Rensen PC, Heeren JUptake of postprandial lipoproteins into bone in vivo: impact on osteoblast functionBone.(2008 Aug)
      170.^Kohlmeier M, Salomon A, Saupe J, Shearer MJTransport of vitamin K to bone in humansJ Nutr.(1996 Apr)
      173.^Conly JM, Stein KEThe absorption and bioactivity of bacterially synthesized menaquinonesClin Invest Med.(1993 Feb)
      174.^Ichihashi T, Takagishi Y, Uchida K, Yamada HColonic absorption of menaquinone-4 and menaquinone-9 in ratsJ Nutr.(1992 Mar)
      177.^Ronden JE, Drittij-Reijnders MJ, Vermeer C, Thijssen HHIntestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the ratBiochim Biophys Acta.(1998 Jan 8)
      178.^Nakagawa K, Hirota Y, Sawada N, Yuge N, Watanabe M, Uchino Y, Okuda N, Shimomura Y, Suhara Y, Okano TIdentification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzymeNature.(2010 Nov 4)
      180.^McDonald MG, Rieder MJ, Nakano M, Hsia CK, Rettie AECYP4F2 is a vitamin K1 oxidase: An explanation for altered warfarin dose in carriers of the V433M variantMol Pharmacol.(2009 Jun)
      182.^Shah NS, Lazarus MC, Bugdodel R, Hsia SL, He J, Duncan R, Baumann LThe effects of topical vitamin K on bruising after laser treatmentJ Am Acad Dermatol.(2002 Aug)
      183.^Lopes LB, Speretta FF, Bentley MVEnhancement of skin penetration of vitamin K using monoolein-based liquid crystalline systemsEur J Pharm Sci.(2007 Nov)
      184.^Lopes LB, Ferreira DA, de Paula D, Garcia MT, Thomazini JA, Fantini MC, Bentley MVReverse hexagonal phase nanodispersion of monoolein and oleic acid for topical delivery of peptides: in vitro and in vivo skin penetration of cyclosporin APharm Res.(2006 Jun)
      185.^Lopes LB, Collett JH, Bentley MVTopical delivery of cyclosporin A: an in vitro study using monoolein as a penetration enhancerEur J Pharm Biopharm.(2005 May)
      187.^Vos M, Esposito G, Edirisinghe JN, Vilain S, Haddad DM, Slabbaert JR, Van Meensel S, Schaap O, De Strooper B, Meganathan R, Morais VA, Verstreken PVitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiencyScience.(2012 Jun 8)
      188.^Bhalerao S, Clandinin TRCell biology. Vitamin K2 takes chargeScience.(2012 Jun 8)
      190.^Suvarna K, Stevenson D, Meganathan R, Hudspeth MEMenaquinone (vitamin K2) biosynthesis: localization and characterization of the menA gene from Escherichia coliJ Bacteriol.(1998 May)
      191.^Clark IE, Dodson MW, Jiang C, Cao JH, Huh JR, Seol JH, Yoo SJ, Hay BA, Guo MDrosophila pink1 is required for mitochondrial function and interacts genetically with parkinNature.(2006 Jun 29)
      192.^Park J, Lee SB, Lee S, Kim Y, Song S, Kim S, Bae E, Kim J, Shong M, Kim JM, Chung JMitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkinNature.(2006 Jun 29)
      193.^Huber AM, Davidson KW, O'Brien-Morse ME, Sadowski JATissue phylloquinone and menaquinones in rats are affected by age and genderJ Nutr.(1999 May)
      194.^Carrié I, Portoukalian J, Vicaretti R, Rochford J, Potvin S, Ferland GMenaquinone-4 concentration is correlated with sphingolipid concentrations in rat brainJ Nutr.(2004 Jan)
      195.^Carrié I, Bélanger E, Portoukalian J, Rochford J, Ferland GLifelong low-phylloquinone intake is associated with cognitive impairments in old ratsJ Nutr.(2011 Aug)
      199.^Hall JG, Pauli RM, Wilson KMMaternal and fetal sequelae of anticoagulation during pregnancyAm J Med.(1980 Jan)
      201.^Bartke N, Hannun YABioactive sphingolipids: metabolism and functionJ Lipid Res.(2009 Apr)
      204.^Sundaram KS, Fan JH, Engelke JA, Foley AL, Suttie JW, Lev MVitamin K status influences brain sulfatide metabolism in young mice and ratsJ Nutr.(1996 Nov)
      206.^Crivello NA, Casseus SL, Peterson JW, Smith DE, Booth SLAge- and brain region-specific effects of dietary vitamin K on myelin sulfatidesJ Nutr Biochem.(2010 Nov)
      208.^Lev M, Milford AFVitamin K stimulation of sphingolipid synthesisBiochem Biophys Res Commun.(1971 Oct 15)
      212.^Sundaram KS, Lev MVitamin K and phosphate mediated enhancement of brain sulfotransferase activityBiochem Biophys Res Commun.(1990 Jun 29)
      213.^Sundaram KS, Lev MPurification and activation of brain sulfotransferaseJ Biol Chem.(1992 Nov 25)
      214.^Sundaram KS, Lev MRegulation of sulfotransferase activity by vitamin K in mouse brainArch Biochem Biophys.(1990 Feb 15)
      215.^Sakaue M, Mori N, Okazaki M, Kadowaki E, Kaneko T, Hemmi N, Sekiguchi H, Maki T, Ozawa A, Hara S, Arishima K, Yamamoto MVitamin K has the potential to protect neurons from methylmercury-induced cell death in vitroJ Neurosci Res.(2011 Jul)
      217.^Westhofen P, Watzka M, Marinova M, Hass M, Kirfel G, Müller J, Bevans CG, Müller CR, Oldenburg JHuman vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant functionJ Biol Chem.(2011 Apr 29)
      218.^Allen MP, Zeng C, Schneider K, Xiong X, Meintzer MK, Bellosta P, Basilico C, Varnum B, Heidenreich KA, Wierman MEGrowth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and AktMol Endocrinol.(1999 Feb)
      220.^Shankar SL, O'Guin K, Cammer M, McMorris FA, Stitt TN, Basch RS, Varnum B, Shafit-Zagardo BThe growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a phosphatidylinositol 3-kinase-dependent pathwayJ Neurosci.(2003 May 15)
      221.^Yagami T, Ueda K, Asakura K, Okamura N, Sakaeda T, Sakaguchi G, Itoh N, Hashimoto Y, Nakano T, Fujimoto MEffect of Gas6 on secretory phospholipase A(2)-IIA-induced apoptosis in cortical neuronsBrain Res.(2003 Sep 26)
      222.^Yagami T, Ueda K, Asakura K, Sakaeda T, Nakazato H, Kuroda T, Hata S, Sakaguchi G, Itoh N, Nakano T, Kambayashi Y, Tsuzuki HGas6 rescues cortical neurons from amyloid beta protein-induced apoptosisNeuropharmacology.(2002 Dec)
      225.^Stitt TN, Conn G, Gore M, Lai C, Bruno J, Radziejewski C, Mattsson K, Fisher J, Gies DR, Jones PF, et alThe anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinasesCell.(1995 Feb 24)
      226.^Phillips DJ, Greengard JS, Fernandez JA, Ribeiro M, Evatt BL, Griffin JH, Hooper WCProtein S, an antithrombotic factor, is synthesized and released by neural tumor cellsJ Neurochem.(1993 Jul)
      227.^Liu D, Guo H, Griffin JH, Fernández JA, Zlokovic BVProtein S confers neuronal protection during ischemic/hypoxic injury in miceCirculation.(2003 Apr 8)
      228.^Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BVProtein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like regionJ Neurosci.(2010 Nov 17)
      229.^Nakajima M, Furukawa S, Hayashi K, Yamada A, Kawashima T, Hayashi YAge-dependent survival-promoting activity of vitamin K on cultured CNS neuronsBrain Res Dev Brain Res.(1993 May 21)
      230.^Li R, Chen J, Hammonds G, Phillips H, Armanini M, Wood P, Bunge R, Godowski PJ, Sliwkowski MX, Mather JPIdentification of Gas6 as a growth factor for human Schwann cellsJ Neurosci.(1996 Mar 15)
      232.^Reddi K, Henderson B, Meghji S, Wilson M, Poole S, Hopper C, Harris M, Hodges SJInterleukin 6 production by lipopolysaccharide-stimulated human fibroblasts is potently inhibited by naphthoquinone (vitamin K) compoundsCytokine.(1995 Apr)
      233.^Moriya M, Nakatsuji Y, Okuno T, Hamasaki T, Sawada M, Sakoda SVitamin K2 ameliorates experimental autoimmune encephalomyelitis in Lewis ratsJ Neuroimmunol.(2005 Dec 30)
      234.^Ohsaki Y, Shirakawa H, Hiwatashi K, Furukawa Y, Mizutani T, Komai MVitamin K suppresses lipopolysaccharide-induced inflammation in the ratBiosci Biotechnol Biochem.(2006 Apr)
      235.^Sato Y, Nakamura R, Satoh M, Fujishita K, Mori S, Ishida S, Yamaguchi T, Inoue K, Nagao T, Ohno YThyroid hormone targets matrix Gla protein gene associated with vascular smooth muscle calcificationCirc Res.(2005 Sep 16)
      236.^Binder MD, Cate HS, Prieto AL, Kemper D, Butzkueven H, Gresle MM, Cipriani T, Jokubaitis VG, Carmeliet P, Kilpatrick TJGas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelinationJ Neurosci.(2008 May 14)
      237.^Tsiperson V, Li X, Schwartz GJ, Raine CS, Shafit-Zagardo BGAS6 enhances repair following cuprizone-induced demyelinationPLoS One.(2010 Dec 23)
      238.^Presse N1, Belleville S, Gaudreau P, Greenwood CE, Kergoat MJ, Morais JA, Payette H, Shatenstein B, Ferland GVitamin K status and cognitive function in healthy older adultsNeurobiol Aging.(2013 Dec)
      239.^Stenhoff J, Dahlbäck B, Hafizi SVitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblastsBiochem Biophys Res Commun.(2004 Jul 2)
      240.^Drolet B, Emond A, Fortin V, Daleau P, Rousseau G, Cardinal R, Turgeon JVitamin K modulates cardiac action potential by blocking sodium and potassium ion channelsJ Cardiovasc Pharmacol Ther.(2000 Oct)
      241.^Soedirman JR, De Bruijn EA, Maes RA, Hanck A, Grüter JPharmacokinetics and tolerance of intravenous and intramuscular phylloquinone (vitamin K1) mixed micelles formulationBr J Clin Pharmacol.(1996 Jun)
      242.^Stafford DWThe vitamin K cycleJ Thromb Haemost.(2005 Aug)
      244.^Stenflo J, Fernlund P, Egan W, Roepstorff PVitamin K dependent modifications of glutamic acid residues in prothrombinProc Natl Acad Sci U S A.(1974 Jul)
      245.^Cranenburg EC, Schurgers LJ, Vermeer CVitamin K: the coagulation vitamin that became omnipotentThromb Haemost.(2007 Jul)
      246.^Krueger T, Westenfeld R, Schurgers L, Brandenburg VCoagulation meets calcification: the vitamin K systemInt J Artif Organs.(2009 Feb)
      247.^Zieman SJ, Melenovsky V, Kass DAMechanisms, pathophysiology, and therapy of arterial stiffnessArterioscler Thromb Vasc Biol.(2005 May)
      249.^Detrano RC, Doherty TM, Davies MJ, Stary HCPredicting coronary events with coronary calcium: pathophysiologic and clinical problemsCurr Probl Cardiol.(2000 Jun)
      251.^Tota-Maharaj R, Blaha MJ, McEvoy JW, Blumenthal RS, Muse ED, Budoff MJ, Shaw LJ, Berman DS, Rana JS, Rumberger J, Callister T, Rivera J, Agatston A, Nasir KCoronary artery calcium for the prediction of mortality in young adults <45 years old and elderly adults >75 years oldEur Heart J.(2012 Dec)
      253.^Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, Liu K, Shea S, Szklo M, Bluemke DA, O'Leary DH, Tracy R, Watson K, Wong ND, Kronmal RACoronary calcium as a predictor of coronary events in four racial or ethnic groupsN Engl J Med.(2008 Mar 27)
      254.^Thompson GR, Partridge JCoronary calcification score: the coronary-risk impact factorLancet.(2004 Feb 14)
      255.^Shea MK, Booth SL, Miller ME, Burke GL, Chen H, Cushman M, Tracy RP, Kritchevsky SBAssociation between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of AtherosclerosisAm J Clin Nutr.(2013 Jul)
      256.^Shea MK, O'Donnell CJ, Hoffmann U, Dallal GE, Dawson-Hughes B, Ordovas JM, Price PA, Williamson MK, Booth SLVitamin K supplementation and progression of coronary artery calcium in older men and womenAm J Clin Nutr.(2009 Jun)
      257.^Kuller LH, Matthews KA, Edmundowicz D, Chang YIncident coronary artery calcium among postmenopausal womenAtherosclerosis.(2008 Oct)
      258.^Kronmal RA, McClelland RL, Detrano R, Shea S, Lima JA, Cushman M, Bild DE, Burke GLRisk factors for the progression of coronary artery calcification in asymptomatic subjects: results from the Multi-Ethnic Study of Atherosclerosis (MESA)Circulation.(2007 May 29)
      259.^Murshed M, Schinke T, McKee MD, Karsenty GExtracellular matrix mineralization is regulated locally; different roles of two gla-containing proteinsJ Cell Biol.(2004 Jun 7)
      260.^Schurgers LJ, Cranenburg EC, Vermeer CMatrix Gla-protein: the calcification inhibitor in need of vitamin KThromb Haemost.(2008 Oct)
      261.^Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty GSpontaneous calcification of arteries and cartilage in mice lacking matrix GLA proteinNature.(1997 Mar 6)
      262.^Schurgers LJ, Teunissen KJ, Knapen MH, Kwaijtaal M, van Diest R, Appels A, Reutelingsperger CP, Cleutjens JP, Vermeer CNovel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcificationArterioscler Thromb Vasc Biol.(2005 Aug)
      263.^Dhore CR, Cleutjens JP, Lutgens E, Cleutjens KB, Geusens PP, Kitslaar PJ, Tordoir JH, Spronk HM, Vermeer C, Daemen MJDifferential expression of bone matrix regulatory proteins in human atherosclerotic plaquesArterioscler Thromb Vasc Biol.(2001 Dec)
      264.^Schurgers LJ, Barreto DV, Barreto FC, Liabeuf S, Renard C, Magdeleyns EJ, Vermeer C, Choukroun G, Massy ZAThe circulating inactive form of matrix gla protein is a surrogate marker for vascular calcification in chronic kidney disease: a preliminary reportClin J Am Soc Nephrol.(2010 Apr)
      265.^Cranenburg EC, Vermeer C, Koos R, Boumans ML, Hackeng TM, Bouwman FG, Kwaijtaal M, Brandenburg VM, Ketteler M, Schurgers LJThe circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcificationJ Vasc Res.(2008)
      266.^Schurgers LJ, Spronk HM, Soute BA, Schiffers PM, DeMey JG, Vermeer CRegression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in ratsBlood.(2007 Apr 1)
      268.^Schurgers LJ, Shearer MJ, Soute BA, Elmadfa I, Harvey J, Wagner KH, Tomasch R, Vermeer CNovel effects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young menJ Lipid Res.(2002 Jun)
      269.^Shea MK, O'Donnell CJ, Vermeer C, Magdeleyns EJ, Crosier MD, Gundberg CM, Ordovas JM, Kritchevsky SB, Booth SLCirculating uncarboxylated matrix gla protein is associated with vitamin K nutritional status, but not coronary artery calcium, in older adultsJ Nutr.(2011 Aug)
      270.^Villines TC, Hatzigeorgiou C, Feuerstein IM, O'Malley PG, Taylor AJVitamin K1 intake and coronary calcificationCoron Artery Dis.(2005 May)
      271.^Braam LA, Hoeks AP, Brouns F, Hamulyák K, Gerichhausen MJ, Vermeer CBeneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up studyThromb Haemost.(2004 Feb)
      273.^Gower BA, Pollock NK, Casazza K, Clemens TL, Goree LL, Granger WMAssociations of total and undercarboxylated osteocalcin with peripheral and hepatic insulin sensitivity and β-cell function in overweight adultsJ Clin Endocrinol Metab.(2013 Apr 24)
      274.^Shea MK, Gundberg CM, Meigs JB, Dallal GE, Saltzman E, Yoshida M, Jacques PF, Booth SLGamma-carboxylation of osteocalcin and insulin resistance in older men and womenAm J Clin Nutr.(2009 Nov)
      275.^Pittas AG, Harris SS, Eliades M, Stark P, Dawson-Hughes BAssociation between serum osteocalcin and markers of metabolic phenotypeJ Clin Endocrinol Metab.(2009 Mar)
      276.^Kindblom JM, Ohlsson C, Ljunggren O, Karlsson MK, Tivesten A, Smith U, Mellström DPlasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish menJ Bone Miner Res.(2009 May)
      277.^Im JA, Yu BP, Jeon JY, Kim SHRelationship between osteocalcin and glucose metabolism in postmenopausal womenClin Chim Acta.(2008 Oct)
      278.^Fernández-Real JM, Izquierdo M, Ortega F, Gorostiaga E, Gómez-Ambrosi J, Moreno-Navarrete JM, Frühbeck G, Martínez C, Idoate F, Salvador J, Forga L, Ricart W, Ibañez JThe relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance trainingJ Clin Endocrinol Metab.(2009 Jan)
      279.^Yoshida M, Booth SL, Meigs JB, Saltzman E, Jacques PFPhylloquinone intake, insulin sensitivity, and glycemic status in men and womenAm J Clin Nutr.(2008 Jul)
      280.^Juanola-Falgarona M, Salas-Salvadó J, Estruch R, Portillo MP, Casas R, Miranda J, Martínez-González MA, Bulló MAssociation between dietary phylloquinone intake and peripheral metabolic risk markers related to insulin resistance and diabetes in elderly subjects at high cardiovascular riskCardiovasc Diabetol.(2013 Jan 8)
      281.^Ibarrola-Jurado N, Salas-Salvadó J, Martínez-González MA, Bulló MDietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular diseaseAm J Clin Nutr.(2012 Nov)
      284.^Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki TThe fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesityNat Med.(2001 Aug)
      285.^Kubota N, Terauchi Y, Yamauchi T, Kubota T, Moroi M, Matsui J, Eto K, Yamashita T, Kamon J, Satoh H, Yano W, Froguel P, Nagai R, Kimura S, Kadowaki T, Noda TDisruption of adiponectin causes insulin resistance and neointimal formationJ Biol Chem.(2002 Jul 19)
      286.^Kadowaki T, Yamauchi T, Waki H, Iwabu M, Okada-Iwabu M, Nakamura MAdiponectin, adiponectin receptors, and epigenetic regulation of adipogenesisCold Spring Harb Symp Quant Biol.(2011)
      288.^Koshihara Y, Hoshi K, Okawara R, Ishibashi H, Yamamoto SVitamin K stimulates osteoblastogenesis and inhibits osteoclastogenesis in human bone marrow cell cultureJ Endocrinol.(2003 Mar)
      289.^Mani S, Huang H, Sundarababu S, Liu W, Kalpana G, Smith AB, Horwitz SBActivation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agentsClin Cancer Res.(2005 Sep 1)
      290.^Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterström RH, Perlmann T, Lehmann JMAn orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathwayCell.(1998 Jan 9)
      291.^Koshihara Y, Hoshi K, Ishibashi H, Shiraki MVitamin K2 promotes 1alpha,25(OH)2 vitamin D3-induced mineralization in human periosteal osteoblastsCalcif Tissue Int.(1996 Dec)
      292.^Akedo Y, Hosoi T, Inoue S, Ikegami A, Mizuno Y, Kaneki M, Nakamura T, Ouchi Y, Orimo HVitamin K2 modulates proliferation and function of osteoblastic cells in vitroBiochem Biophys Res Commun.(1992 Sep 16)
      293.^Akiyama Y, Hara K, Tajima T, Murota S, Morita IEffect of vitamin K2 (menatetrenone) on osteoclast-like cell formation in mouse bone marrow culturesEur J Pharmacol.(1994 Sep 22)
      294.^Price PA, Otsuka AA, Poser JW, Kristaponis J, Raman NCharacterization of a gamma-carboxyglutamic acid-containing protein from boneProc Natl Acad Sci U S A.(1976 May)
      295.^Hauschka PV, Lian JB, Gallop PMDirect identification of the calcium-binding amino acid, gamma-carboxyglutamate, in mineralized tissueProc Natl Acad Sci U S A.(1975 Oct)
      296.^Fusaro M, Crepaldi G, Maggi S, Galli F, D'Angelo A, Calò L, Giannini S, Miozzo D, Gallieni MVitamin K, bone fractures, and vascular calcifications in chronic kidney disease: an important but poorly studied relationshipJ Endocrinol Invest.(2011 Apr)
      298.^Hoang QQ, Sicheri F, Howard AJ, Yang DSBone recognition mechanism of porcine osteocalcin from crystal structureNature.(2003 Oct 30)
      299.^Mizuguchi M, Fujisawa R, Nara M, Nitta K, Kawano KFourier-transform infrared spectroscopic study of Ca2+-binding to osteocalcinCalcif Tissue Int.(2001 Dec)
      300.^Ducy P, Desbois C, Boyce B, Pinero G, Story B, Dunstan C, Smith E, Bonadio J, Goldstein S, Gundberg C, Bradley A, Karsenty GIncreased bone formation in osteocalcin-deficient miceNature.(1996 Aug 1)
      306.^Mawatari T, Miura H, Higaki H, Moro-Oka T, Kurata K, Murakami T, Iwamoto YEffect of vitamin K2 on three-dimensional trabecular microarchitecture in ovariectomized ratsJ Bone Miner Res.(2000 Sep)
      307.^Fang Y, Hu C, Tao X, Wan Y, Tao FEffect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trialsJ Bone Miner Metab.(2012 Jan)
      308.^Braam LA, Knapen MH, Geusens P, Brouns F, Hamulyák K, Gerichhausen MJ, Vermeer CVitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of ageCalcif Tissue Int.(2003 Jul)
      309.^Purwosunu Y, Muharram, Rachman IA, Reksoprodjo S, Sekizawa AVitamin K2 treatment for postmenopausal osteoporosis in IndonesiaJ Obstet Gynaecol Res.(2006 Apr)
      311.^Nishiguchi S, Shimoi S, Kurooka H, Tamori A, Habu D, Takeda T, Kubo SRandomized pilot trial of vitamin K2 for bone loss in patients with primary biliary cirrhosisJ Hepatol.(2001 Oct)
      312.^Somekawa Y, Chigughi M, Harada M, Ishibashi TUse of vitamin K2 (menatetrenone) and 1,25-dihydroxyvitamin D3 in the prevention of bone loss induced by leuprolideJ Clin Endocrinol Metab.(1999 Aug)
      313.^Sasaki N, Kusano E, Takahashi H, Ando Y, Yano K, Tsuda E, Asano YVitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG)J Bone Miner Metab.(2005)
      314.^Knapen MH, Drummen NE, Smit E, Vermeer C, Theuwissen EThree-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal womenOsteoporos Int.(2013 Sep)
      315.^Braam LA, Knapen MH, Geusens P, Brouns F, Vermeer CFactors affecting bone loss in female endurance athletes: a two-year follow-up studyAm J Sports Med.(2003 Nov-Dec)
      317.^Booth SL, Dallal G, Shea MK, Gundberg C, Peterson JW, Dawson-Hughes BEffect of vitamin K supplementation on bone loss in elderly men and womenJ Clin Endocrinol Metab.(2008 Apr)
      318.^Shea MK, Dallal GE, Dawson-Hughes B, Ordovas JM, O'Donnell CJ, Gundberg CM, Peterson JW, Booth SLVitamin K, circulating cytokines, and bone mineral density in older men and womenAm J Clin Nutr.(2008 Aug)
      319.^Binkley N, Harke J, Krueger D, Engelke J, Vallarta-Ast N, Gemar D, Checovich M, Chappell R, Suttie JVitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American womenJ Bone Miner Res.(2009 Jun)
      320.^Forli L, Bollerslev J, Simonsen S, Isaksen GA, Kvamsdal KE, Godang K, Gadeholt G, Pripp AH, Bjortuft ODietary vitamin K2 supplement improves bone status after lung and heart transplantationTransplantation.(2010 Feb 27)
      321.^Emaus N, Gjesdal CG, Almås B, Christensen M, Grimsgaard AS, Berntsen GK, Salomonsen L, Fønnebø VVitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trialOsteoporos Int.(2010 Oct)
      322.^Hart JP, Catterall A, Dodds RA, Klenerman L, Shearer MJ, Bitensky L, Chayen JCirculating vitamin K1 levels in fractured neck of femurLancet.(1984 Aug 4)
      323.^Luukinen H, Käkönen SM, Pettersson K, Koski K, Laippala P, Lövgren T, Kivelä SL, Väänänen HKStrong prediction of fractures among older adults by the ratio of carboxylated to total serum osteocalcinJ Bone Miner Res.(2000 Dec)
      326.^Falcone TD, Kim SS, Cortazzo MHVitamin K: fracture prevention and beyondPM R.(2011 Jun)
      329.^Inoue T, Fujita T, Kishimoto H, Makino T, Nakamura T, Nakamura T, Sato T, Yamazaki KRandomized controlled study on the prevention of osteoporotic fractures (OF study): a phase IV clinical study of 15-mg menatetrenone capsulesJ Bone Miner Metab.(2009)
      330.^Neogi T, Booth SL, Zhang YQ, Jacques PF, Terkeltaub R, Aliabadi P, Felson DTLow vitamin K status is associated with osteoarthritis in the hand and kneeArthritis Rheum.(2006 Apr)
      331.^Oka H, Akune T, Muraki S, En-yo Y, Yoshida M, Saika A, Sasaki S, Nakamura K, Kawaguchi H, Yoshimura NAssociation of low dietary vitamin K intake with radiographic knee osteoarthritis in the Japanese elderly population: dietary survey in a population-based cohort of the ROAD studyJ Orthop Sci.(2009 Nov)
      333.^Newman B, Gigout LI, Sudre L, Grant ME, Wallis GACoordinated expression of matrix Gla protein is required during endochondral ossification for chondrocyte survivalJ Cell Biol.(2001 Aug 6)
      334.^Luo G, D'Souza R, Hogue D, Karsenty GThe matrix Gla protein gene is a marker of the chondrogenesis cell lineage during mouse developmentJ Bone Miner Res.(1995 Feb)
      335.^Yagami K, Suh JY, Enomoto-Iwamoto M, Koyama E, Abrams WR, Shapiro IM, Pacifici M, Iwamoto MMatrix GLA protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous ossification in the limbJ Cell Biol.(1999 Nov 29)
      336.^Hale JE, Fraser JD, Price PAThe identification of matrix Gla protein in cartilageJ Biol Chem.(1988 Apr 25)
      337.^Munroe PB, Olgunturk RO, Fryns JP, Van Maldergem L, Ziereisen F, Yuksel B, Gardiner RM, Chung EMutations in the gene encoding the human matrix Gla protein cause Keutel syndromeNat Genet.(1999 Jan)
      338.^Misra D, Booth SL, Crosier MD, Ordovas JM, Felson DT, Neogi TMatrix Gla protein polymorphism, but not concentrations, is associated with radiographic hand osteoarthritisJ Rheumatol.(2011 Sep)
      339.^Shea MK, Booth SL, Massaro JM, Jacques PF, D'Agostino RB Sr, Dawson-Hughes B, Ordovas JM, O'Donnell CJ, Kathiresan S, Keaney JF Jr, Vasan RS, Benjamin EJVitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring StudyAm J Epidemiol.(2008 Feb 1)
      340.^Kopp E, Medzhitov RRecognition of microbial infection by Toll-like receptorsCurr Opin Immunol.(2003 Aug)
      341.^Tanaka S, Nishiumi S, Nishida M, Mizushina Y, Kobayashi K, Masuda A, Fujita T, Morita Y, Mizuno S, Kutsumi H, Azuma T, Yoshida MVitamin K3 attenuates lipopolysaccharide-induced acute lung injury through inhibition of nuclear factor-kappaB activationClin Exp Immunol.(2010 May)
      342.^Sasaki T, Knyazev PG, Cheburkin Y, Göhring W, Tisi D, Ullrich A, Timpl R, Hohenester ECrystal structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor tyrosine kinase activation by laminin G-like domainsJ Biol Chem.(2002 Nov 15)
      345.^Grishkovskaya I, Avvakumov GV, Sklenar G, Dales D, Hammond GL, Muller YACrystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domainEMBO J.(2000 Feb 15)
      347.^Son BK, Akishita M, Iijima K, Ogawa S, Maemura K, Yu J, Takeyama K, Kato S, Eto M, Ouchi YAndrogen receptor-dependent transactivation of growth arrest-specific gene 6 mediates inhibitory effects of testosterone on vascular calcificationJ Biol Chem.(2010 Mar 5)
      348.^Lukert BP, Raisz LGGlucocorticoid-induced osteoporosis: pathogenesis and managementAnn Intern Med.(1990 Mar 1)
      349.^Reid IRGlucocorticoid osteoporosis--mechanisms and managementEur J Endocrinol.(1997 Sep)
      351.^Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Lüthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R, Boyle WJOsteoprotegerin: a novel secreted protein involved in the regulation of bone densityCell.(1997 Apr 18)
      352.^Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJOsteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationCell.(1998 Apr 17)
      353.^Sasaki N, Kusano E, Ando Y, Yano K, Tsuda E, Asano YGlucocorticoid decreases circulating osteoprotegerin (OPG): possible mechanism for glucocorticoid induced osteoporosisNephrol Dial Transplant.(2001 Mar)
      354.^Thomas DD, Krzykowski KJ, Engelke JA, Groblewski GEExocrine pancreatic secretion of phospholipid, menaquinone-4, and caveolin-1 in vivoBiochem Biophys Res Commun.(2004 Jul 2)
      355.^Stenberg LM, Nilsson E, Ljungberg O, Stenflo J, Brown MASynthesis of gamma-carboxylated polypeptides by alpha-cells of the pancreatic isletsBiochem Biophys Res Commun.(2001 May 4)
      356.^Prasad KN, Edwards-Prasad J, Sakamoto AVitamin K3 (menadione) inhibits the growth of mammalian tumor cells in cultureLife Sci.(1981 Sep 28)
      358.^Ngo EO, Sun TP, Chang JY, Wang CC, Chi KH, Cheng AL, Nutter LMMenadione-induced DNA damage in a human tumor cell lineBiochem Pharmacol.(1991 Oct 24)
      360.^Lamson DW, Plaza SMThe anticancer effects of vitamin KAltern Med Rev.(2003 Aug)
      361.^Saxena SP, Israels ED, Israels LGNovel vitamin K-dependent pathways regulating cell survivalApoptosis.(2001 Feb-Apr)
      363.^Avanzi GC, Gallicchio M, Bottarel F, Gammaitoni L, Cavalloni G, Buonfiglio D, Bragardo M, Bellomo G, Albano E, Fantozzi R, Garbarino G, Varnum B, Aglietta M, Saglio G, Dianzani U, Dianzani CGAS6 inhibits granulocyte adhesion to endothelial cellsBlood.(1998 Apr 1)
      366.^Nishikawa Y, Carr BI, Wang M, Kar S, Finn F, Dowd P, Zheng ZB, Kerns J, Naganathan SGrowth inhibition of hepatoma cells induced by vitamin K and its analogsJ Biol Chem.(1995 Nov 24)
      367.^Chlebowski RT, Dietrich M, Akman S, Block JBVitamin K3 inhibition of malignant murine cell growth and human tumor colony formationCancer Treat Rep.(1985 May)
      368.^Wang Z, Wang M, Finn F, Carr BIThe growth inhibitory effects of vitamins K and their actions on gene expressionHepatology.(1995 Sep)
      370.^Hassan GSMenadioneProfiles Drug Subst Excip Relat Methodol.(2013)
      374.^Lou WW, Quintana AT, Geronemus RG, Grossman MCEffects of topical vitamin K and retinol on laser-induced purpura on nonlesional skinDermatol Surg.(1999 Dec)
      376.^Kovács RK, Bodai L, Dobozy A, Kemény LLack of the effect of topical vitamin K on bruising after mechanical injuryJ Am Acad Dermatol.(2004 Jun)
      377.^Howe AM, Webster WS, Lipson AH, Halliday JL, Sheffield LJBinder's syndrome due to prenatal vitamin K deficiency: a theory of pathogenesisAust Dent J.(1992 Dec)
      378.^Irving MD, Chitty LS, Mansour S, Hall CMChondrodysplasia punctata: a clinical diagnostic and radiological reviewClin Dysmorphol.(2008 Oct)
      379.^Shearer MJVitamin K metabolism and nutritureBlood Rev.(1992 Jun)
      380.^Greer FR, Marshall S, Cherry J, Suttie JWVitamin K status of lactating mothers, human milk, and breast-feeding infantsPediatrics.(1991 Oct)
      381.^Canfield LM, Hopkinson JM, Lima AF, Martin GS, Sugimoto K, Burr J, Clark L, McGee DLQuantitation of vitamin K in human milkLipids.(1990 Jul)
      382.^Canfield LM, Hopkinson JM, Lima AF, Silva B, Garza CVitamin K in colostrum and mature human milk over the lactation period--a cross-sectional studyAm J Clin Nutr.(1991 Mar)
      383.^Kojima T, Asoh M, Yamawaki N, Kanno T, Hasegawa H, Yonekubo AVitamin K concentrations in the maternal milk of Japanese womenActa Paediatr.(2004 Apr)
      384.^Greer FRAre breast-fed infants vitamin K deficientAdv Exp Med Biol.(2001)
      385.^Conway SP, Wolfe SP, Brownlee KG, White H, Oldroyd B, Truscott JG, Harvey JM, Shearer MJVitamin K status among children with cystic fibrosis and its relationship to bone mineral density and bone turnoverPediatrics.(2005 May)
      386.^Sokol RJ, Reardon MC, Accurso FJ, Stall C, Narkewicz MR, Abman SH, Hammond KBFat-soluble vitamins in infants identified by cystic fibrosis newborn screeningPediatr Pulmonol Suppl.(1991)
      387.^Jagannath VA, Fedorowicz Z, Thaker V, Chang ABVitamin K supplementation for cystic fibrosisCochrane Database Syst Rev.(2013 Apr 30)
      388.^Bergen AA, Plomp AS, Schuurman EJ, Terry S, Breuning M, Dauwerse H, Swart J, Kool M, van Soest S, Baas F, ten Brink JB, de Jong PTMutations in ABCC6 cause pseudoxanthoma elasticumNat Genet.(2000 Jun)
      389.^Ringpfeil F, Lebwohl MG, Christiano AM, Uitto JPseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporterProc Natl Acad Sci U S A.(2000 May 23)
      391.^Li Q, Jiang Q, Schurgers LJ, Uitto JPseudoxanthoma elasticum: reduced gamma-glutamyl carboxylation of matrix gla protein in a mouse model (Abcc6-/-)Biochem Biophys Res Commun.(2007 Dec 14)
      392.^Brampton C, Yamaguchi Y, Vanakker O, Van Laer L, Chen LH, Thakore M, De Paepe A, Pomozi V, Szabó PT, Martin L, Váradi A, Le Saux OVitamin K does not prevent soft tissue mineralization in a mouse model of pseudoxanthoma elasticumCell Cycle.(2011 Jun 1)
      395.^Zhang W, Negoro T, Satoh K, Jiang Y, Hashimoto K, Kikuchi H, Nishikawa H, Miyata T, Yamamoto Y, Nakano K, Yasumoto E, Nakayachi T, Mineno K, Satoh T, Sakagami HSynergistic cytotoxic action of vitamin C and vitamin K3Anticancer Res.(2001 Sep-Oct)
      396.^von Gruenigen VE, Jamison JM, Gilloteaux J, Lorimer HE, Summers M, Pollard RR, Gwin CA, Summers JLThe in vitro antitumor activity of vitamins C and K3 against ovarian carcinomaAnticancer Res.(2003 Jul-Aug)
      399.^Nutter LM, Cheng AL, Hung HL, Hsieh RK, Ngo EO, Liu TWMenadione: spectrum of anticancer activity and effects on nucleotide metabolism in human neoplastic cell linesBiochem Pharmacol.(1991 May 1)
      401.^Steingrimsdottir L, Gunnarsson O, Indridason OS, Franzson L, Sigurdsson GRelationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intakeJAMA.(2005 Nov 9)
      402.^Miyake N, Hoshi K, Sano Y, Kikuchi K, Tadano K, Koshihara Y1,25-Dihydroxyvitamin D3 promotes vitamin K2 metabolism in human osteoblastsOsteoporos Int.(2001)
      403.^Price PA, Faus SA, Williamson MKWarfarin-induced artery calcification is accelerated by growth and vitamin DArterioscler Thromb Vasc Biol.(2000 Feb)
      406.^Booth SL, Golly I, Sacheck JM, Roubenoff R, Dallal GE, Hamada K, Blumberg JBEffect of vitamin E supplementation on vitamin K status in adults with normal coagulation statusAm J Clin Nutr.(2004 Jul)
      409.^Crowther MA, Donovan D, Harrison L, McGinnis J, Ginsberg JLow-dose oral vitamin K reliably reverses over-anticoagulation due to warfarinThromb Haemost.(1998 Jun)
      410.^Denas G, Marzot F, Offelli P, Stendardo A, Cucchini U, Russo R, Nante G, Iliceto S, Pengo VEffectiveness and safety of a management protocol to correct over-anticoagulation with oral vitamin K: a retrospective study of 1,043 casesJ Thromb Thrombolysis.(2009 Apr)
      411.^Rombouts EK, Rosendaal FR, Van Der Meer FJDaily vitamin K supplementation improves anticoagulant stabilityJ Thromb Haemost.(2007 Oct)
      414.^Reese AM, Farnett LE, Lyons RM, Patel B, Morgan L, Bussey HILow-dose vitamin K to augment anticoagulation controlPharmacotherapy.(2005 Dec)
      415.^Chiou TJ, Zhang J, Ferrans VJ, Tzeng WFCardiac and renal toxicity of menadione in ratToxicology.(1997 Dec 31)
      416.^Songy KA Jr, Layon AJVitamin K-induced cardiovascular collapseJ Clin Anesth.(1997 Sep)
      417.^Barash P, Kitahata LM, Mandel SAcute cardiovascular collapse after intravenous phytonadioneAnesth Analg.(1976 Mar-Apr)
      418.^Lefrère JJ, Girot RAcute cardiovascular collapse during intravenous vitamin K1 injectionThromb Haemost.(1987 Aug 4)
      424.^Radjendirane V, Joseph P, Lee YH, Kimura S, Klein-Szanto AJ, Gonzalez FJ, Jaiswal AKDisruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicityJ Biol Chem.(1998 Mar 27)
      428.^Monks TJ, Hanzlik RP, Cohen GM, Ross D, Graham DGQuinone chemistry and toxicityToxicol Appl Pharmacol.(1992 Jan)
      429.^Takahashi N, Schreiber J, Fischer V, Mason RPFormation of glutathione-conjugated semiquinones by the reaction of quinones with glutathione: an ESR studyArch Biochem Biophys.(1987 Jan)
      430.^Wilson I, Wardman P, Lin TS, Sartorelli ACReactivity of thiols towards derivatives of 2- and 6-methyl-1,4-naphthoquinone bioreductive alkylating agentsChem Biol Interact.(1987 Mar)
      431.^Grant TW, Doherty MD, Odowole D, Sales KD, Cohen GMSemiquinone anion radicals formed by the reaction of quinones with glutathione or amino acidsFEBS Lett.(1986 Jun 9)
      433.^Zadziński R, Fortuniak A, Biliński T, Grey M, Bartosz GMenadione toxicity in Saccharomyces cerevisiae cells: activation by conjugation with glutathioneBiochem Mol Biol Int.(1998 Apr)