Vitamin B6 (pyridoxine) has been used as a supplement to reduce prolactin levels. A trial of 60 women of reproductive age showed that 300 mg of vitamin B6 taken in 3 separate doses daily reduced prolactin similarly to cabergoline.[1]
Vitamin B6 has also been suggested as a treatment for hyperprolactinemia caused by antipsychotic medications (like risperidone or haloperidol) and may effectively reduce prolactin levels and improve symptoms of hyperprolactinemia in people who take these medications.[2][3]
Low vitamin D levels are more common in women with hyperprolactinemia and prolactinoma (a prolactin-producing tumor) than in women without hyperprolactinemia. This association might not be causal; however, a low vitamin D level combined with an elevated prolactin level can lead to a decrease in bone density, especially in postmenopausal women.[4][5] With this in mind, a vitamin D supplement is useful in certain patients with hyperprolactinemia. It is best to check the vitamin D level before starting supplementation.
References
- ^Witwit, S et alThe role of vitamin B6 in reducing prolactin in comparison to cabergolineInt J Pharm Qual.(2019-03)
- ^Lu Z, Sun Y, Zhang Y, Chen Y, Guo L, Liao Y, Kang Z, Feng X, Yue WPharmacological treatment strategies for antipsychotic-induced hyperprolactinemia: a systematic review and network meta-analysis.Transl Psychiatry.(2022 Jul 5)
- ^Zhuo C, Xu Y, Wang H, Fang T, Chen J, Zhou C, Li Q, Liu J, Xu S, Yao C, Yang W, Yang A, Li B, Chen Y, Tian H, Lin CSafety and Efficacy of High-Dose Vitamin B6 as an Adjunctive Treatment for Antipsychotic-Induced Hyperprolactinemia in Male Patients With Treatment-Resistant Schizophrenia.Front Psychiatry.(2021)
- ^Aboelnaga MM, Abdullah N, El Shaer M25-hydroxyvitamin D Correlation with Prolactin Levels and Adenoma Size in Female Patients with Newly Diagnosed Prolactin Secreting Adenoma.Endocr Metab Immune Disord Drug Targets.(2017)
- ^Krysiak R, Kowalska B, Szkróbka W, Okopień BThe association between macroprolactin levels and vitamin D status in premenopausal women with macroprolactinemia: a pilot study.Exp Clin Endocrinol Diabetes.(2015-Sep)