Mild Cognitive Impairment (MCI)

    Written by:
    Thomas Solomon

    Fact-checked

    by:

    Louie Neri, James Gaylor
    Last Updated: October 13, 2024

    MCI is a form of cognitive decline where changes are serious enough to be noticed by the affected individual and their family members, but not severe enough to interfere with normal activities of daily living.

    38 references on this page
    9,695 participants in 11 trials and 10 meta-analyses

    Overview

    Examine Database: Mild Cognitive Impairment (MCI)

    Research FeedRead all studies

    Frequently asked questions

    Examine Database References

    1. Blood Pressure - Newhouse P, Kellar K, Aisen P, White H, Wesnes K, Coderre E, Pfaff A, Wilkins H, Howard D, Levin EDNicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trialNeurology.(2012 Jan 10)
    2. Depression Symptoms - Krikorian R, Eliassen JC, Boespflug EL, Nash TA, Shidler MDImproved cognitive-cerebral function in older adults with chromium supplementationNutr Neurosci.(2010 Jun)
    3. Depression Symptoms - Krikorian R, Nash TA, Shidler MD, Shukitt-Hale B, Joseph JAConcord grape juice supplementation improves memory function in older adults with mild cognitive impairmentBr J Nutr.(2010 Mar)
    4. Memory - Schreiber S, Kampf-Sherf O, Gorfine M, Kelly D, Oppenheim Y, Lerer BAn open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive declineIsr J Psychiatry Relat Sci.(2000)
    5. Memory - McBean L, O'Reilly SDiet quality interventions to prevent neurocognitive decline: a systematic review and meta-analysis.Eur J Clin Nutr.(2022-Aug)
    6. Memory - Marx W, Kelly JT, Marshall S, Cutajar J, Annois B, Pipingas A, Tierney A, Itsiopoulos CEffect of resveratrol supplementation on cognitive performance and mood in adults: a systematic literature review and meta-analysis of randomized controlled trials.Nutr Rev.(2018-Jun-01)
    7. Memory - Xu C, Bi S, Zhang W, Luo LThe effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis.Front Nutr.(2024)
    8. Memory - Tripathi S, Kaushik M, Dwivedi R, Tiwari P, Tripathi M, Dada RThe effect of probiotics on select cognitive domains in mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis.J Alzheimers Dis Rep.(2024)
    9. Cognition - Konstantinos I Avgerinos, Josephine M Egan, Mark P Mattson, Dimitrios KapogiannisMedium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer's disease. A systematic review and meta-analysis of human studiesAgeing Res Rev.(2020 Mar)
    10. Cognition - Meer N, Fischer TMedium-Chain Triglycerides (MCTs) for the Symptomatic Treatment of Dementia-Related Diseases: A Systematic Review.J Nutr Metab.(2024)
    11. Cognition - Park SK, Jung IC, Lee WK, Lee YS, Park HK, Go HJ, Kim K, Lim NK, Hong JT, Ly SY, Rho SSA combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled studyJ Med Food.(2011 Apr)
    12. Cognition - Key-Chung Park, Hui Jin, Renhua Zheng, Sehyun Kim, Seung-Eun Lee, Bo-Hyung Kim, Sung-Vin YimCognition enhancing effect of panax ginseng in Korean volunteers with mild cognitive impairment: a randomized, double-blind, placebo-controlled clinical trialTransl Clin Pharmacol.(2019 Sep)
    13. Cognition - Wang M, Fang M, Zang WEffects of folic acid supplementation on cognitive function and inflammation in elderly patients with mild cognitive impairment: A systematic review and meta-analysis of randomized controlled trials.Arch Gerontol Geriatr.(2024 Jun 19)
    14. Cognition - Li X, Chen B, Liu X, Ma JEffects of exercise on cognitive function and glycated hemoglobin A1c among patients with type 2 diabetes mellitus and cognitive impairment: A systematic review and meta-analysis.Geriatr Gerontol Int.(2025 Jan 5)
    15. Cognition - Farina N, Llewellyn D, Isaac MGEKN, Tabet NVitamin E for Alzheimer's dementia and mild cognitive impairment.Cochrane Database Syst Rev.(2017 Apr 18)
    16. Alzheimer's Disease Risk - Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S, Galasko D, Jin S, Kaye J, Levey A, Pfeiffer E, Sano M, van Dyck CH, Thal LJ, Alzheimer's Disease Cooperative Study GroupVitamin E and donepezil for the treatment of mild cognitive impairmentN Engl J Med.(2005 Jun 9)
    17. Testosterone - Yamada S, Akishita M, Fukai S, Ogawa S, Yamaguchi K, Matsuyama J, Kozaki K, Toba K, Ouchi YEffects of dehydroepiandrosterone supplementation on cognitive function and activities of daily living in older women with mild to moderate cognitive impairmentGeriatr Gerontol Int.(2010 Oct)
    18. Cognitive Decline - Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida TImproving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trialPhytother Res.(2009 Mar)
    19. Cognitive Decline - Waegemans T, Wilsher CR, Danniau A, Ferris SH, Kurz A, Winblad BClinical efficacy of piracetam in cognitive impairment: a meta-analysisDement Geriatr Cogn Disord.(2002)
    20. Alzheimer's Disease Symptoms - Sudesh Prabhakar, Venugopalan Y Vishnu, Manish Modi, Manju Mohanty, Anchal Sharma, Bikas Medhi, B R Mittal, Niranjan Khandelwal, Manoj K Goyal, Vivek Lal, Rajesh Singla, Avinash Kansal, Ajit AvasthiEfficacy of Bacopa Monnieri (Brahmi) and Donepezil in Alzheimer's Disease and Mild Cognitive Impairment: A Randomized Double-Blind Parallel Phase 2b StudyAnn Indian Acad Neurol.(Nov-Dec 2020)
    21. Cerebral Trauma Rehabilitation - Neznamov GG, Teleshova ESComparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic originNeurosci Behav Physiol.(2009 Mar)