How is mild cognitive impairment diagnosed?

    Last Updated: October 25, 2023

    The factors that can cause poor memory and thinking skills but are unrelated to dementia (e.g., medications, alcohol, poor sleep, and head injuries) are first ruled out with a medical history. The subsequent diagnosis of mild cognitive impairment involves several steps. Cognitive, neurological, and physical function tests are used to confirm poor memory and thinking skills and to identify problems with movement, coordination, and balance. Additional diagnostic tests may also be used to identify possible causes. For example, brain imaging tests like magnetic resonance imaging (MRI) or positron emission tomography (PET) can detect abnormalities in brain structure, while biochemical tests can detect abnormalities in tau and beta-amyloid protein levels in the cerebrospinal fluid (CSF).[1][2][3][4]

    References

    1. ^Marilyn S Albert, Steven T DeKosky, Dennis Dickson, Bruno Dubois, Howard H Feldman, Nick C Fox, Anthony Gamst, David M Holtzman, William J Jagust, Ronald C Petersen, Peter J Snyder, Maria C Carrillo, Bill Thies, Creighton H PhelpsThe diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseAlzheimers Dement.(2011 May)
    2. ^Frederiksen KS, Nielsen TR, Winblad B, Schmidt R, Kramberger MG, Jones RW, Hort J, Grimmer T, Georges J, Frölich L, Engelborghs S, Dubois B, Waldemar GEuropean Academy of Neurology/European Alzheimer's Disease Consortium position statement on diagnostic disclosure, biomarker counseling, and management of patients with mild cognitive impairment.Eur J Neurol.(2021-Jul)
    3. ^Ronald C Petersen, Oscar Lopez, Melissa J Armstrong, Thomas S D Getchius, Mary Ganguli, David Gloss, Gary S Gronseth, Daniel Marson, Tamara Pringsheim, Gregory S Day, Mark Sager, James Stevens, Alexander Rae-GrantPractice guideline update summary: Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of NeurologyNeurology.(2018 Jan 16)
    4. ^Chen YX, Liang N, Li XL, Yang SH, Wang YP, Shi NNDiagnosis and Treatment for Mild Cognitive Impairment: A Systematic Review of Clinical Practice Guidelines and Consensus Statements.Front Neurol.(2021)