Yes, there may be. Silymarin, an extract from milk thistle that has antioxidant and anti-inflammatory properties, has been shown to improve both AST and ALT[1] in people with NAFLD. Furthermore, it has been shown to reduce fasting blood glucose[2] in people with type 2 diabetes. Berberine may also benefit people with NAFLD. A randomized-controlled trial showed that berberine was beneficial for reducing hepatic fat content[3] on top of lifestyle modifications, with a similar efficacy as a thiazolidinedione. There are a handful of other nutraceuticals currently being investigated (e.g., curcumin, CoQ10) but do not currently have substantial enough evidence to indicate they are beneficial.
References
- ^Zhong S, Fan Y, Yan Q, Fan X, Wu B, Han Y, Zhang Y, Chen Y, Zhang H, Niu JThe therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease: A meta-analysis (PRISMA) of randomized control trialsMedicine (Baltimore).(2017 Dec)
- ^Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic ASilymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsJ Diabetes Res.(2016)
- ^Yan HM, Xia MF, Wang Y, Chang XX, Yao XZ, Rao SX, Zeng MS, Tu YF, Feng R, Jia WP, Liu J, Deng W, Jiang JD, Gao XEfficacy of Berberine in Patients with Non-Alcoholic Fatty Liver DiseasePLoS One.(2015 Aug 7)