Curcumin

Last Updated: September 28 2022

Curcumin is the primary bioactive substance in turmeric. It has anti-inflammatory properties, and there is decent evidence that it can alleviate various conditions, from chronic pain to depression. Curcumin has poor bioavailability on its own, and thus it is often combined with black-pepper or with lipids.

Curcumin is most often used for

What is curcumin?

Curcumin — a yellow pigment found primarily in turmeric (a flowering plant of the ginger family best known as a spice used in curry) — is a polyphenol with anti-inflammatory properties and the ability to increase the amount of antioxidants that the body produces.

Curcumin and the curcuminoids found in turmeric can be extracted to produce supplements that have a much higher potency than turmeric. However, curcumin is absorbed poorly during digestion, so a myriad of different formulations have been created to improve its bioavailability.

What are curcumin’s main benefits?

Supplementation with curcumin reliably reduces markers of inflammation and increases the levels of endogenous antioxidants in the body. More research is needed on curcumin for many areas of health, but the available research supports small to moderate improvements in the symptoms of depression and anxiety and in pain and function in osteoarthritis. Reductions in LDL cholesterol, blood-glucose, and blood-pressure are possible, but the research on these outcomes is limited and less consistent.

What are curcumin’s main drawbacks?

One of curcumin’s greatest drawbacks is that it is poorly absorbed when orally ingested by itself. Regarding potential adverse effects, doses of up to 8 grams of curcuminoids have not been associated with serious adverse effects in humans. However, long-term studies that are more comprehensive in their assessments are needed. Studies using high doses of curcumin have reported some mild adverse effects, including nausea, diarrhea, headache, skin rash, and yellow stool. Use of curcumin with piperine a black pepper extract may cause adverse drug reactions because piperine greatly increases intestinal permeability. Not all formulations of curcumin have been safety tested to the same degree.

How does curcumin work?

The potential beneficial effects of curcumin seem to be mainly the result of its anti-inflammatory and antioxidant properties. These properties are mediated by curcumin’s direct or indirect interaction with (and modulation of) various molecular targets, including transcription factors, enzymes, cell cycle proteins, receptors, cell surface adhesion molecules, growth factors, and protein kinases.

What else is Curcumin known as?
Note that Curcumin is also known as:
  • Turmeric extract
  • Curry Extract
  • Curcuma
  • Diferuloylmethane
  • JiangHuang
  • Curcuma Longa
  • 1 7-Bis(4-hydroxy-3-3methoxyphenyl)hepta-1 6-diene-3 5-dione
Curcumin should not be confused with:
  • Turmeric (Spice it comes from)
  • Curry (meal preparation using Turmeric)
  • Tree Turmeric (a term for Berberis Aristata)

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    Dosage information

    By itself, curcumin is poorly absorbed. Among the methods devised to address the issue, the two most common (and most often tested) are to pair curcumin with piperine (a black pepper extract) or to combine it with lipids (BCM-95®, Meriva® …).

    To supplement curcumin with piperine, take 500 mg of the former with 5-6.7 mg of the latter, thrice a day (i.e., 1,500 mg of curcumin and 15-20 mg of piperine per day).

    To supplement BCM-95®, a patented combination of curcumin and essential oils, take 500 mg twice a day (i.e., 1,000 mg/day).

    To supplement Meriva®, a patented combination of curcumin and soy lecithin, take 200–500 mg twice a day (i.e., 400–1,000 mg/day).

    Curcumin is usually taken together with food.

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