Supplements studied for PPD include vitamin B6,[1] vitamin D,[2][3][4] fish oil/omega-3 fatty acids,[5][6][7][8][9] folate,[10] and saffron.[11][12]
While the symptoms of PPD match those of major depression, many more supplements have been studied for major depression than have been evaluated for safety during pregnancy/ postpartum and for efficacy in PPD.
References
- ^Maryam Khodadad, Parvin Bahadoran, Gholam Reza Kheirabadi, Ali Mohammad SabzghabaeeCan Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled TrialInt J Prev Med.(2021 Oct 19)
- ^Vaziri F, Nasiri S, Tavana Z, Dabbaghmanesh MH, Sharif F, Jafari PA randomized controlled trial of vitamin D supplementation on perinatal depression: in Iranian pregnant mothersBMC Pregnancy Childbirth.(2016 Aug 20)
- ^Amini S, Jafarirad S, Amani RPostpartum depression and vitamin D: A systematic review.Crit Rev Food Sci Nutr.(2019)
- ^Gould JF, Gibson RA, Green TJ, Makrides MA Systematic Review of Vitamin D during Pregnancy and Postnatally and Symptoms of Depression in the Antenatal and Postpartum Period from Randomized Controlled Trials and Observational Studies.Nutrients.(2022-May-30)
- ^Juliana Dos Santos Vaz, Dayana Rodrigues Farias, Amanda Rodrigues Amorim Adegboye, Antonio Egidio Nardi, Gilberto KacOmega-3 supplementation from pregnancy to postpartum to prevent depressive symptoms: a randomized placebo-controlled trialBMC Pregnancy Childbirth.(2017 Jun 9)
- ^Su KP, Huang SY, Chiu TH, Huang KC, Huang CL, Chang HC, Pariante CMOmega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trialJ Clin Psychiatry.(2008 Apr)
- ^Makrides M, Gibson RA, McPhee AJ, Yelland L, Quinlivan J, Ryan P; DOMInO Investigative TeamEffect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trialJAMA.(2010 Oct 20)
- ^Taciana Maia de Sousa, Luana Caroline Dos SantosEffect of antenatal omega-3 supplementation on maternal depressive symptoms from pregnancy to 6 months postpartum: a randomized double-blind placebo-controlled trialNutr Neurosci.(2022 May 2)
- ^Mi-Mi Zhang, Yan Zou, Su-Min Li, Li Wang, Yu-Hui Sun, Le Shi, Lin Lu, Yan-Ping Bao, Su-Xia LiThe efficacy and safety of omega-3 fatty acids on depressive symptoms in perinatal women: a meta-analysis of randomized placebo-controlled trialsTransl Psychiatry.(2020 Jun 17)
- ^Deligiannidis KM, Freeman MPComplementary and alternative medicine therapies for perinatal depression.Best Pract Res Clin Obstet Gynaecol.(2014-Jan)
- ^Jamshid Tabeshpour, Farzaneh Sobhani, Seyed Alireza Sadjadi, Hossein Hosseinzadeh, Seyed Ahmad Mohajeri, Omid Rajabi, Zhila Taherzadeh, Saeid EslamiA double-blind, randomized, placebo-controlled trial of saffron stigma (Crocus sativus L.) in mothers suffering from mild-to-moderate postpartum depressionPhytomedicine.(2017 Dec 1)
- ^L Kashani, S Eslatmanesh, N Saedi, N Niroomand, M Ebrahimi, M Hosseinian, T Foroughifar, S Salimi, S AkhondzadehComparison of Saffron versus Fluoxetine in Treatment of Mild to Moderate Postpartum Depression: A Double-Blind, Randomized Clinical TrialPharmacopsychiatry.(2017 Mar)