The risk of peripheral arterial disease increases with age [1] and is greater in people who have atherosclerotic disease (narrowing or blockage of an artery) in another region of the body besides the legs.[2] People with obesity or diabetes also have an increased risk of peripheral arterial disease. Additionally, there are several modifiable risk factors, including smoking, physical inactivity, high blood lipid concentrations (total cholesterol and triglycerides), and high blood pressure.[1][3][2][4] Additionally, there are genetic risk factors, meaning that peripheral arterial disease is not only driven by lifestyle but is also inheritable.[5][6][7][8]
References
- ^Song P, Rudan D, Zhu Y, Fowkes FJI, Rahimi K, Fowkes FGR, Rudan IGlobal, regional, and national prevalence and risk factors for peripheral artery disease in 2015: an updated systematic review and analysis.Lancet Glob Health.(2019-Aug)
- ^Gerhard-Herman MD, Gornik HL, Barrett C, Barshes NR, Corriere MA, Drachman DE, Fleisher LA, Fowkes FG, Hamburg NM, Kinlay S, Lookstein R, Misra S, Mureebe L, Olin JW, Patel RA, Regensteiner JG, Schanzer A, Shishehbor MH, Stewart KJ, Treat-Jacobson D, Walsh ME2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.Circulation.(2017-Mar-21)
- ^Fowkes FG, Rudan D, Rudan I, Aboyans V, Denenberg JO, McDermott MM, Norman PE, Sampson UK, Williams LJ, Mensah GA, Criqui MHComparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysisLancet.(2013 Oct 19)
- ^Tsao CW, Aday AW, Almarzooq ZI, Alonso A, Beaton AZ, Bittencourt MS, Boehme AK, Buxton AE, Carson AP, Commodore-Mensah Y, Elkind MSV, Evenson KR, Eze-Nliam C, Ferguson JF, Generoso G, Ho JE, Kalani R, Khan SS, Kissela BM, Knutson KL, Levine DA, Lewis TT, Liu J, Loop MS, Ma J, Mussolino ME, Navaneethan SD, Perak AM, Poudel R, Rezk-Hanna M, Roth GA, Schroeder EB, Shah SH, Thacker EL, VanWagner LB, Virani SS, Voecks JH, Wang NY, Yaffe K, Martin SSHeart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association.Circulation.(2022-Feb-22)
- ^Klarin D, Lynch J, Aragam K, Chaffin M, Assimes TL, Huang J, Lee KM, Shao Q, Huffman JE, Natarajan P, Arya S, Small A, Sun YV, Vujkovic M, Freiberg MS, Wang L, Chen J, Saleheen D, Lee JS, Miller DR, Reaven P, Alba PR, Patterson OV, DuVall SL, Boden WE, Beckman JA, Gaziano JM, Concato J, Rader DJ, Cho K, Chang KM, Wilson PWF, O'Donnell CJ, Kathiresan S, , Tsao PS, Damrauer SMGenome-wide association study of peripheral artery disease in the Million Veteran Program.Nat Med.(2019-Aug)
- ^Wassel CL, Loomba R, Ix JH, Allison MA, Denenberg JO, Criqui MHFamily history of peripheral artery disease is associated with prevalence and severity of peripheral artery disease: the San Diego population study.J Am Coll Cardiol.(2011-Sep-20)
- ^Wahlgren CM, Magnusson PKGenetic influences on peripheral arterial disease in a twin population.Arterioscler Thromb Vasc Biol.(2011-Mar)
- ^Klarin D, Tsao PS, Damrauer SMGenetic Determinants of Peripheral Artery Disease.Circ Res.(2021-Jun-11)