How is preeclampsia diagnosed?

    Last Updated: October 13, 2024

    Preeclampsia is diagnosed by the onset of high blood pressure and signs of organ damage after 20 weeks gestation (though very rarely it may occur earlier). The formal criteria for a diagnosis include:

    • Blood pressure elevation as follows:
    • Systolic blood pressure elevation of ≥140 mmHg or diastolic blood pressure elevation of ≥90 mmHg on two occasions at least four hours apart, OR
    • blood pressure elevation of ≥ 160/110 mmHg on two occasions at least several minutes apart
    • Proteinuria (≥ 300 mg/24 hours, or protein/creatinine ratio of ≥ 0.3, or +2 by dipstick testing if quantitative measurement is not available)[1][2][3][4], OR at least one of the following signs:
    • Elevated creatinine (>1 mg/dL)[5]
    • Low platelets (<100 x 109/L)[6]
    • Liver dysfunction (elevated transaminases)
    • Fluid in the lungs (pulmonary edema)
    • Neurological dysfunction (hyperreflexia, visual disturbances, headache)[5][7]

    References

    1. ^Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy.Am J Obstet Gynecol.(2000 Jul)
    2. ^Wu P, Haththotuwa R, Kwok CS, Babu A, Kotronias RA, Rushton C, Zaman A, Fryer AA, Kadam U, Chew-Graham CA, Mamas MAPreeclampsia and Future Cardiovascular Health: A Systematic Review and Meta-Analysis.Circ Cardiovasc Qual Outcomes.(2017-Feb)
    3. ^Khaing W, Vallibhakara SA, Tantrakul V, Vallibhakara O, Rattanasiri S, McEvoy M, Attia J, Thakkinstian ACalcium and Vitamin D Supplementation for Prevention of Preeclampsia: A Systematic Review and Network Meta-Analysis.Nutrients.(2017-Oct-18)
    4. ^Hofmeyr GJ, Lawrie TA, Atallah AN, Duley L, Torloni MRCalcium supplementation during pregnancy for preventing hypertensive disorders and related problemsCochrane Database Syst Rev.(2014 Jun 24)
    5. ^Ahmed R, Dunford J, Mehran R, Robson S, Kunadian VPre-eclampsia and future cardiovascular risk among women: a review.J Am Coll Cardiol.(2014-May-13)
    6. ^Ciobanu AM, Colibaba S, Cimpoca B, Peltecu G, Panaitescu AMThrombocytopenia in Pregnancy.Maedica (Bucur).(2016-Mar)
    7. ^American College of Obstetricians and GynecologistsGestational Hypertension and PreeclampsiaObstetrics & Gynecology.(June 2020)