Have any supplements been studied for systemic lupus erythematosus?

    Last Updated: October 25, 2023

    Fish oil,[1] curcumin,[2] probiotics,[3] green tea extract,[4] nicotinamide adenine dinucleotide (NAD+),[5] melatonin,[6] and a variety of antioxidants and vitamins have been studied for their effects on SLE. While some of these supplements show promise in alleviating SLE symptoms, they are generally not recommended as primary or stand-alone treatments for SLE. Human trials reporting the efficacy of these supplements can be found here.

    References

    1. ^Alí Duarte-García, Elena Myasoedova, Paras Karmacharya, Mehmet Hocaoğlu, M Hassan Murad, Kenneth J Warrington, Cynthia S CrowsonEffect of omega-3 fatty acids on systemic lupus erythematosus disease activity: A systematic review and meta-analysisAutoimmun Rev.(2020 Dec)
    2. ^Khajehdehi P, Zanjaninejad B, Aflaki E, Nazarinia M, Azad F, Malekmakan L, Dehghanzadeh GROral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: a randomized and placebo-controlled studyJ Ren Nutr.(2012 Jan)
    3. ^de Oliveira GLV, Leite AZ, Higuchi BS, Gonzaga MI, Mariano VSIntestinal dysbiosis and probiotic applications in autoimmune diseases.Immunology.(2017-09)
    4. ^Shamekhi Z, Amani R, Habibagahi Z, Namjoyan F, Ghadiri A, Saki Malehi AA Randomized, Double-blind, Placebo-controlled Clinical Trial Examining the Effects of Green Tea Extract on Systemic Lupus Erythematosus Disease Activity and Quality of Life.Phytother Res.(2017-Jul)
    5. ^Wu J, Singh K, Lin A, Meadows AM, Wu K, Shing V, Bley M, Hassanzadeh S, Huffstutler RD, Schmidt MS, Blanco LP, Tian R, Brenner C, Pirooznia M, Kaplan MJ, Sack MNBoosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes.J Clin Invest.(2022-03-01)
    6. ^Mohammadmahdi Nabatian-Asl, Amir Ghorbanihaghjo, Aida Malek Mahdavi, Alireza Khabbazi, Mehrzad Hajialilo, Morteza GhojazadehEffects of melatonin supplementation on serum oxidative stress markers and disease activity in systemic lupus erythematosus patients: A randomised, double-blind, placebo-controlled trialInt J Clin Pract.(2021 Apr 20)