Paleolithic Diet

Last Updated: September 28 2022

Paleo diets are a set of eating patterns that limit or exclude foods that were unavailable to our Paleolithic ancestors. Randomized trials suggest well-formulated paleo diets may be as effective as other healthy diets for weight loss and improving markers of metabolic health. Risks of a well-formulated paleo diet are minimal, but more restrictive versions can cause nutrient deficiencies and health issues.

Paleolithic Diet is most often used for

What is a paleo diet?

Paleolithic (paleo) diets are a group of dietary patterns that approximate what our Paleolithic ancestors ate. They are usually minimally processed, whole-food diets full of plants and animal products. Paleo diets commonly limit or completely exclude grains, dairy, legumes, starchy root vegetables, and processed foods.[1]

What are paleo diets used for?

While paleo may be considered a panacea in some popular circles, randomized trials have shown that paleo can be used for modest positive effects on weight loss,[2][3][4] glucose regulation,[5][6] blood lipids,[7][4] and other markers of cardiometabolic health.[3][7][4][5] These effects are comparable to those seen with other healthy diets, but paleo may lead to greater weight loss, especially in the short term.[8][3]

How safe is paleo?

Moderate paleo diets are generally safe, but more extreme paleo diets may pose risks.

Extremely carbohydrate-restricted paleo diets can lead to lactation ketoacidosis (a rare condition that may arise when a lactating woman’s energy needs are not being met through diet) in breastfeeding women.[9]

Paleo diets that are very high in protein (>2.5 grams protein per kilogram (kg) of body weight per day, or about one-third of calories from protein) may increase risk of kidney stones and kidney dysfunction.[10] The relationship has not been confirmed in more rigorous randomized trials, and does not apply to paleo diets with more moderate levels of protein.[11]

A balanced paleo diet should include sources of iodine, calcium, and vitamin D to prevent nutrient insufficiency or deficiency.[12][13][13][14][15]

How does the paleo diet work?

Paleo diets may lead to weight loss by making calorie restriction easier with nutrient-dense, highly satiating foods that emphasize fiber, protein, and fat.[16][17] The positive effects on blood pressure, blood lipids, and other cardiometabolic outcomes may be due to the inclusion of particular nutrients (omega-3 fatty acids, potassium, magnesium) and the exclusion of others (sugar, salt, high-glycemic carbohydrates, excessive saturated fat).[18][19][20][13][8][5]

What else is Paleolithic Diet known as?
Note that Paleolithic Diet is also known as:
  • Ancestral diet
  • Paleo diet
  • Hunter-gatherer diet
Paleolithic Diet should not be confused with:
  • Carnivore diet
  • Ketogenic diet
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References
1.^Víctor de la O, Itziar Zazpe, J Alfredo Martínez, Susana Santiago, Silvia Carlos, M Ángeles Zulet, Miguel Ruiz-CanelaScoping review of Paleolithic dietary patterns: a definition proposalNutr Res Rev.(2021 Jun)
2.^Ehrika Vanessa Almeida de Menezes, Helena Alves de Carvalho Sampaio, Antônio Augusto Ferreira Carioca, Nara Andrade Parente, Filipe Oliveira Brito, Thereza Maria Magalhães Moreira, Ana Célia Caetano de Souza, Soraia Pinheiro Machado ArrudaInfluence of Paleolithic diet on anthropometric markers in chronic diseases: systematic review and meta-analysisNutr J.(2019 Jul 23)
3.^Barbara Frączek, Aleksandra Pięta, Adrian Burda, Paulina Mazur-Kurach, Florentyna TyrałaPaleolithic Diet-Effect on the Health Status and Performance of Athletes?Nutrients.(2021 Mar 21)
4.^Ehsan Ghaedi, Mohammad Mohammadi, Hamed Mohammadi, Nahid Ramezani-Jolfaie, Janmohamad Malekzadeh, Mahdieh Hosseinzadeh, Amin Salehi-AbargoueiEffects of a Paleolithic Diet on Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsAdv Nutr.(2019 Jul 1)
5.^Mohammad Hassan Sohouli, Somaye Fatahi, Abolfazl Lari, Mojtaba Lotfi, Maryam Seifishahpar, Mihnea-Alexandru Găman, Seyedeh Tayebeh Rahideh, Saud K AlBatati, Abdullah M AlHossan, Sara A Alkhalifa, Sara A Alomar, Ahmed Abu-ZaidThe effect of paleolithic diet on glucose metabolism and lipid profile among patients with metabolic disorders: a systematic review and meta-analysis of randomized controlled trialsCrit Rev Food Sci Nutr.(2021 Jan 25)
6.^Małgorzata Jamka, Bartosz Kulczyński, Agata Juruć, Anna Gramza-Michałowska, Caroline S Stokes, Jarosław WalkowiakThe Effect of the Paleolithic Diet vs. Healthy Diets on Glucose and Insulin Homeostasis: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsJ Clin Med.(2020 Jan 21)
7.^Eric W Manheimer, Esther J van Zuuren, Zbys Fedorowicz, Hanno PijlPaleolithic nutrition for metabolic syndrome: systematic review and meta-analysisAm J Clin Nutr.(2015 Oct)
8.^C Mellberg, S Sandberg, M Ryberg, M Eriksson, S Brage, C Larsson, T Olsson, B LindahlLong-term effects of a Palaeolithic-type diet in obese postmenopausal women: a 2-year randomized trialEur J Clin Nutr.(2014 Mar)
9.^Abdullah M Al Alawi, Asma Al Flaiti, Henrik FalhammarLactation Ketoacidosis: A Systematic Review of Case ReportsMedicina (Kaunas).(2020 Jun 17)
10.^Shalini T Reddy, Chia-Ying Wang, Khashayar Sakhaee, Linda Brinkley, Charles Y C PakEffect of low-carbohydrate high-protein diets on acid-base balance, stone-forming propensity, and calcium metabolismAm J Kidney Dis.(2002 Aug)
12.^S Manousou, M Stål, C Larsson, C Mellberg, B Lindahl, R Eggertsen, L Hulthén, T Olsson, M Ryberg, S Sandberg, H F NyströmA Paleolithic-type diet results in iodine deficiency: a 2-year randomized trial in postmenopausal obese womenEur J Clin Nutr.(2018 Jan)
14.^M Osterdahl, T Kocturk, A Koochek, P E WändellEffects of a short-term intervention with a paleolithic diet in healthy volunteersEur J Clin Nutr.(2008 May)
15.^Karlsen MC, Livingston KA, Agoulnik D, Miki A, Lichtenstein AH, Gilhooly CH, Folta SC, Economos CD, McKeown NMPart 2: Theoretical Intakes of Modern-Day Paleo Diets: Comparison With Dietary Reference Intakes and MyPlate Meal PlansNutr Today.(2021 Jul)
17.^Tommy Jönsson, Yvonne Granfeldt, Charlotte Erlanson-Albertsson, Bo Ahrén, Staffan LindebergA paleolithic diet is more satiating per calorie than a mediterranean-like diet in individuals with ischemic heart diseaseNutr Metab (Lond).(2010 Nov 30)
18.^K S Culling, H A W Neil, M Gilbert, K N FraynEffects of short-term low- and high-carbohydrate diets on postprandial metabolism in non-diabetic and diabetic subjectsNutr Metab Cardiovasc Dis.(2009 Jun)
19.^Joshua Z Goldenberg, Andrew Day, Grant D Brinkworth, Junko Sato, Satoru Yamada, Tommy Jönsson, Jennifer Beardsley, Jeffrey A Johnson, Lehana Thabane, Bradley C JohnstonEfficacy and safety of low and very low carbohydrate diets for type 2 diabetes remission: systematic review and meta-analysis of published and unpublished randomized trial dataBMJ.(2021 Jan 13)
21.^Toth N, Schick KOverview of Paleolithic ArchaeologyHandbook of Paleoanthropology.(2014 Feb)
22.^Klein RGThe human career: human biological and cultural originsThe University of Chicago Press.(2009)
24.^Amanda G Henry, Alison S Brooks, Dolores R PipernoPlant foods and the dietary ecology of Neanderthals and early modern humansJ Hum Evol.(2014 Apr)
25.^Ainara Sistiaga, Carolina Mallol, Bertila Galván, Roger Everett SummonsThe Neanderthal meal: a new perspective using faecal biomarkersPLoS One.(2014 Jun 25)
26.^H Pontzer, B M Wood, D A RaichlenHunter-gatherers as models in public healthObes Rev.(2018 Dec)
27.^Gauree G Konijeti, NaMee Kim, James D Lewis, Shauna Groven, Anita Chandrasekaran, Sirisha Grandhe, Caroline Diamant, Emily Singh, Glenn Oliveira, Xiaoyun Wang, Bhuvan Molparia, Ali TorkamaniEfficacy of the Autoimmune Protocol Diet for Inflammatory Bowel DiseaseInflamm Bowel Dis.(2017 Nov)
29.^Anita Chandrasekaran, Shauna Groven, James D Lewis, Susan S Levy, Caroline Diamant, Emily Singh, Gauree Gupta KonijetiAn Autoimmune Protocol Diet Improves Patient-Reported Quality of Life in Inflammatory Bowel DiseaseCrohns Colitis 360.(2019 Oct)
30.^Kelly Fellows Maxwell, Terry Wahls, Richard W Browne, Linda Rubenstein, Babita Bisht, Catherine A Chenard, Linda Snetselaar, Bianca Weinstock-Guttman, Murali RamanathanLipid profile is associated with decreased fatigue in individuals with progressive multiple sclerosis following a diet-based intervention: Results from a pilot studyPLoS One.(2019 Jun 18)
31.^Anna Revedin, Biancamaria Aranguren, Roberto Becattini, Laura Longo, Emanuele Marconi, Marta Mariotti Lippi, Natalia Skakun, Andrey Sinitsyn, Elena Spiridonova, Jirí SvobodaThirty thousand-year-old evidence of plant food processingProc Natl Acad Sci U S A.(2010 Nov 2)
32.^Price TDThe European MesolithicAm Antiq.(1983 Oct))
33.^Otte MThe Paleolithic-Mesolithic TransitionSourcebook of Paleolithic Transitions.(2009)
34.^Maïté Rivollat, Choongwon Jeong, Stephan Schiffels, İşil Küçükkalıpçı, Marie-Hélène Pemonge, Adam Benjamin Rohrlach, Kurt W Alt, Didier Binder, Susanne Friederich, Emmanuel Ghesquière, Detlef Gronenborn, Luc Laporte, Philippe Lefranc, Harald Meller, Hélène Réveillas, Eva Rosenstock, Stéphane Rottier, Chris Scarre, Ludovic Soler, Joachim Wahl, Johannes Krause, Marie-France Deguilloux, Wolfgang HaakAncient genome-wide DNA from France highlights the complexity of interactions between Mesolithic hunter-gatherers and Neolithic farmersSci Adv.(2020 May 29)
35.^Pontus Skoglund, Helena Malmström, Maanasa Raghavan, Jan Storå, Per Hall, Eske Willerslev, M Thomas P Gilbert, Anders Götherström, Mattias JakobssonOrigins and genetic legacy of Neolithic farmers and hunter-gatherers in EuropeScience.(2012 Apr 27)
36.^Kristine A Whalen, Suzanne Judd, Marjorie L McCullough, W Dana Flanders, Terryl J Hartman, Roberd M BostickPaleolithic and Mediterranean Diet Pattern Scores Are Inversely Associated with All-Cause and Cause-Specific Mortality in AdultsJ Nutr.(2017 Apr)
37.^Suzanna Maria Zick, Detrick Snyder, Donald I AbramsPros and Cons of Dietary Strategies Popular Among Cancer PatientsOncology (Williston Park).(2018 Nov 15)
39.^Kristine A Whalen, Marjorie L McCullough, W Dana Flanders, Terryl J Hartman, Suzanne Judd, Roberd M BostickPaleolithic and Mediterranean Diet Pattern Scores Are Inversely Associated with Biomarkers of Inflammation and Oxidative Balance in AdultsJ Nutr.(2016 Jun)
40.^Kristine A Whalen, Marji McCullough, W Dana Flanders, Terryl J Hartman, Suzanne Judd, Roberd M BostickPaleolithic and Mediterranean diet pattern scores and risk of incident, sporadic colorectal adenomasAm J Epidemiol.(2014 Dec 1)
41.^Amanda K Irish, Constance M Erickson, Terry L Wahls, Linda G Snetselaar, Warren G DarlingRandomized control trial evaluation of a modified Paleolithic dietary intervention in the treatment of relapsing-remitting multiple sclerosis: a pilot studyDegener Neurol Neuromuscul Dis.(2017 Jan 4)
42.^Terry L Wahls, Tyler J Titcomb, Babita Bisht, Patrick Ten Eyck, Linda M Rubenstein, Lucas J Carr, Warren G Darling, Karin F Hoth, John Kamholz, Linda G SnetselaarImpact of the Swank and Wahls elimination dietary interventions on fatigue and quality of life in relapsing-remitting multiple sclerosis: The WAVES randomized parallel-arm clinical trialMult Scler J Exp Transl Clin.(2021 Jul 31)
43.^S Lindeberg, T Jönsson, Y Granfeldt, E Borgstrand, J Soffman, K Sjöström, B AhrénA Palaeolithic Diet Improves Glucose Tolerance More Than a Mediterranean-like Diet in Individuals With Ischaemic Heart DiseaseDiabetologia.(2007 Sep)
44.^Li Xu, Xiaoguang Cheng, Jiguang Wang, Qiyun Cao, Tetsuya Sato, Maoying Wang, Xingshan Zhao, Wei LiangComparisons of body-composition prediction accuracy: a study of 2 bioelectric impedance consumer devices in healthy Chinese persons using DXA and MRI as criteria methodsJ Clin Densitom.(Oct-Dec 2011)
45.^Jeannette M Beasley, Brett A Ange, Cheryl A M Anderson, Edgar R Miller 3rd, Thomas P Erlinger, Janet T Holbrook, Frank M Sacks, Lawrence J AppelAssociations between macronutrient intake and self-reported appetite and fasting levels of appetite hormones: results from the Optimal Macronutrient Intake Trial to Prevent Heart DiseaseAm J Epidemiol.(2009 Apr 1)
48.^Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, Peters C, Zhyzhneuskaya S, Al-Mrabeh A, Hollingsworth KG, Rodrigues AM, Rehackova L, Adamson AJ, Sniehotta FF, Mathers JC, Ross HM, McIlvenna Y, Stefanetti R, Trenell M, Welsh P, Kean S, Ford I, McConnachie A, Sattar N, Taylor RPrimary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trialLancet.(2018 Feb 10)
49.^Christopher D Gardner, Lisa C Offringa, Jennifer C Hartle, Kris Kapphahn, Rise CherinWeight loss on low-fat vs. low-carbohydrate diets by insulin resistance status among overweight adults and adults with obesity: A randomized pilot trialObesity (Silver Spring).(2016 Jan)
50.^Sydne J. Newberry, Mei Chung, Cheryl A.M. Anderson, Christine Chen, Zhuxuan Fu, Alice Tang, Naisi Zhao, Marika Booth, Joyce Marks, Simon Hollands, Aneesa Motala, Jody Larkin, Roberta Shanman, Susanne HempelSodium and Potassium Intake: Effects on Chronic Disease Outcomes and Risks Internet.()
52.^Rebecca K Kelly, Cody Z Watling, Tammy Y N Tong, Carmen Piernas, Jennifer L Carter, Keren Papier, Timothy J Key, Aurora Perez-CornagoAssociations Between Macronutrients From Different Dietary Sources and Serum Lipids in 24 639 UK Biobank Study ParticipantsArterioscler Thromb Vasc Biol.(2021 Jul)
54.^Cassandra E Forsythe, Stephen D Phinney, Richard D Feinman, Brittanie M Volk, Daniel Freidenreich, Erin Quann, Kevin Ballard, Michael J Puglisi, Carl M Maresh, William J Kraemer, Douglas M Bibus, Maria Luz Fernandez, Jeff S VolekLimited effect of dietary saturated fat on plasma saturated fat in the context of a low carbohydrate dietLipids.(2010 Oct)
55.^Brittanie M Volk, Laura J Kunces, Daniel J Freidenreich, Brian R Kupchak, Catherine Saenz, Juan C Artistizabal, Maria Luz Fernandez, Richard S Bruno, Carl M Maresh, William J Kraemer, Stephen D Phinney, Jeff S VolekEffects of step-wise increases in dietary carbohydrate on circulating saturated Fatty acids and palmitoleic Acid in adults with metabolic syndromePLoS One.(2014 Nov 21)
58.^S B Eaton, S B Eaton 3rd, M J KonnerPaleolithic nutrition revisited: a twelve-year retrospective on its nature and implicationsEur J Clin Nutr.(1997 Apr)
59.^John Hawks, Eric T Wang, Gregory M Cochran, Henry C Harpending, Robert K MoyzisRecent acceleration of human adaptive evolutionProc Natl Acad Sci U S A.(2007 Dec 26)
60.^Todd Bersaglieri, Pardis C Sabeti, Nick Patterson, Trisha Vanderploeg, Steve F Schaffner, Jared A Drake, Matthew Rhodes, David E Reich, Joel N HirschhornGenetic signatures of strong recent positive selection at the lactase geneAm J Hum Genet.(2004 Jun)
61.^Sarah A Tishkoff, Floyd A Reed, Alessia Ranciaro, Benjamin F Voight, Courtney C Babbitt, Jesse S Silverman, Kweli Powell, Holly M Mortensen, Jibril B Hirbo, Maha Osman, Muntaser Ibrahim, Sabah A Omar, Godfrey Lema, Thomas B Nyambo, Jilur Ghori, Suzannah Bumpstead, Jonathan K Pritchard, Gregory A Wray, Panos DeloukasConvergent adaptation of human lactase persistence in Africa and EuropeNat Genet.(2007 Jan)
62.^L Cordain, J B Miller, S B Eaton, N Mann, S H Holt, J D SpethPlant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer dietsAm J Clin Nutr.(2000 Mar)
63.^Charlton S, Ramsøe A, Collins M, Craig OE, Fischer R, Alexander M, Speller CFNew insights into Neolithic milk consumption through proteomic analysis of dental calculus.Archaeol Anthropol Sci.(2019 Nov)
64.^Davis DR, Epp MD, Riordan HDChanges in USDA food composition data for 43 garden crops, 1950 to 1999J Am Coll Nutr.(2004 Dec)
65.^Boers I, Muskiet FA, Berkelaar E, Schut E, Penders R, Hoenderdos K, Wichers HJ, Jong MCFavourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome: a randomized controlled pilot-studyLipids Health Dis.(2014 Oct 11)
66.^Anthony Cioci, Chad Rudnick, Levonti OhanisianAccidental ketosis-induced polyuria in a toddler: a case reportBMC Pediatr.(2019 Oct 30)
67.^Mackenzie Hartman, Bruce Fuller, Michael R HeaphyPrurigo pigmentosa induced by ketosis: resolution through dietary modificationCutis.(2019 Mar)
68.^An Pan, Qi Sun, Adam M Bernstein, Matthias B Schulze, JoAnn E Manson, Meir J Stampfer, Walter C Willett, Frank B HuRed meat consumption and mortality: results from 2 prospective cohort studiesArch Intern Med.(2012 Apr 9)
69.^G C Curhan, W C Willett, F E Speizer, D Spiegelman, M J StampferComparison of dietary calcium with supplemental calcium and other nutrients as factors affecting the risk for kidney stones in womenAnn Intern Med.(1997 Apr 1)
70.^Kossoff EH, Zupec-Kania BA, Auvin S, Ballaban-Gil KR, Christina Bergqvist AG, Blackford R, Buchhalter JR, Caraballo RH, Cross JH, Dahlin MG, Donner EJ, Guzel O, Jehle RS, Klepper J, Kang HC, Lambrechts DA, Liu YMC, Nathan JK, Nordli DR Jr, Pfeifer HH, Rho JM, Scheffer IE, Sharma S, Stafstrom CE, Thiele EA, Turner Z, Vaccarezza MM, van der Louw EJTM, Veggiotti P, Wheless JW, Wirrell EC, Charlie Foundation, Matthew's Friends, Practice Committee of the Child Neurology SocietyOptimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study GroupEpilepsia Open.(2018 May 21)
71.^G C Curhan, W C Willett, E B Rimm, M J StampferA prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stonesN Engl J Med.(1993 Mar 25)
72.^Gary C Curhan, Walter C Willett, Eric L Knight, Meir J StampferDietary factors and the risk of incident kidney stones in younger women: Nurses' Health Study IIArch Intern Med.(2004 Apr 26)
73.^Julia J Scialla, John Asplin, Mirela Dobre, Alex R Chang, James Lash, Chi-Yuan Hsu, Radhakrishna R Kallem, L Lee Hamm, Harold I Feldman, Jing Chen, Lawrence J Appel, Cheryl A M Anderson, Myles Wolf, Chronic Renal Insufficiency Cohort Study InvestigatorsHigher net acid excretion is associated with a lower risk of kidney disease progression in patients with diabetesKidney Int.(2017 Jan)
75.^Andreas F H Pfeiffer, Eva Pedersen, Ursula Schwab, Ulf Risérus, Anne-Marie Aas, Matti Uusitupa, Anastasia Thanopoulou, Cyril Kendall, John L Sievenpiper, Hana Kahleová, Dario Rahélic, Jordi Salas-Salvadó, Stephanie Gebauer, Kjeld HermansenThe Effects of Different Quantities and Qualities of Protein Intake in People with Diabetes MellitusNutrients.(2020 Jan 30)
76.^L Robertson, N Waugh, A RobertsonProtein restriction for diabetic renal diseaseCochrane Database Syst Rev.(2007 Oct 17)
77.^Sevda Alvirdizadeh, Emad Yuzbashian, Parvin Mirmiran, Shahryar Eghtesadi, Fereidoun AziziA prospective study on total protein, plant protein and animal protein in relation to the risk of incident chronic kidney diseaseBMC Nephrol.(2020 Nov 17)
78.^Parvin Mirmiran, Emad Yuzbashian, Maryam Aghayan, Maryam Mahdavi, Golaleh Asghari, Fereidoun AziziA Prospective Study of Dietary Meat Intake and Risk of Incident Chronic Kidney DiseaseJ Ren Nutr.(2020 Mar)
79.^Diamond E, Tibaldi JA Case Of Ketoacidosis In A Breastfeeding Patient On The Paleo DietEndocr Pract.(2016 May)
80.^Sarah Gleeson, Eoin Mulroy, David E ClarkeLactation Ketoacidosis: An Unusual Entity and a Review of the LiteraturePerm J.(Spring 2016)
81.^Janet M Roseland, Katherine M Phillips, Kristine Y Patterson, Pamela R Pehrsson, Rahul Bahadur, Abby G Ershow, Meena SomanchiLarge Variability of Iodine Content in Retail Cow's Milk in the U.SNutrients.(2020 Apr 28)