Yes, there may be. Silymarin, an extract from milk thistle that has antioxidant and anti-inflammatory properties, has been shown to improve both AST and ALT[1] in people with NAFLD. Furthermore, it has been shown to reduce fasting blood glucose[2] in people with type 2 diabetes. Berberine may also benefit people with NAFLD. A randomized-controlled trial showed that berberine was beneficial for reducing hepatic fat content[3] on top of lifestyle modifications, with a similar efficacy as a thiazolidinedione. There are a handful of other nutraceuticals currently being investigated (e.g., curcumin, CoQ10) but do not currently have substantial enough evidence to indicate they are beneficial.
Are there any other supplements that can help people with NAFLD?
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•Last Updated: April 23, 2025
Silymarin, an extract from milk thistle, may improve liver enzyme levels and reduce fasting blood glucose in people with nonalcoholic fatty liver disease, and berberine has been shown to reduce hepatic fat content. Other nutraceuticals like curcumin and CoQ10 are under investigation but lack substantial evidence of benefit at this time.