Flaxseed has many biologically active compounds that could improve cardiovascular disease (CVD) and reduce the risk of developing CVD.
Alpha-linolenic acid (ALA) has anti-inflammatory effects, and several studies have found that flaxseed supplementation can reduce levels of markers of inflammation like C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α).[1][2][3][4][5] Lignans have antioxidant effects and have been observed to increase total antioxidant capacity (TAC) and reduce malondialdehyde (MDA).[6][1]
The high fiber content of flaxseed can reduce cholesterol levels and may improve blood glucose levels.[7][8][9][10][11][12] Flaxseed might also decrease lipoprotein(a) levels.[13] Flaxseed supplementation has also been shown to lower blood pressure.[14][15] Since these are all risk factors for CVD, flaxseed supplementation could reduce the risk of CVD.[16]