There are many supplements that are mechanistically compelling for CFS, but there’s very little high-quality research on this subject. Currently, the most promising supplements include magnesium, l-carnitine, and s-Adenosyl Methionine. Some supplements, such as probiotics, dark chocolate, and NADH, may improve symptoms of CFS (notably fatigue), but aren’t likely to improve the condition itself.[1]
Have any supplements been studied for chronic fatigue syndrome?
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•Last Updated: May 16, 2025
Although many supplements show potential for chronic fatigue syndrome, high-quality research is lacking. The most promising supplements include magnesium, L-carnitine, and S-adenosyl methionine; others, like probiotics and NADH, possibly alleviate symptoms but do not improve the condition itself.