Have any supplements been studied for PPD?

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    Last Updated: May 16, 2025

    Several supplements have been studied for peripartum depression (PPD), including vitamin B6, vitamin D, fish oil/omega-3 fatty acids, folate, and saffron. However, there are more supplements researched for major depression than for their safety and efficacy in PPD.

    Supplements studied for PPD include vitamin B6,[1] vitamin D,[2][3][4] fish oil/omega-3 fatty acids,[5][6][7][8][9] folate,[10] and saffron.[11][12]

    While the symptoms of PPD match those of major depression, many more supplements have been studied for major depression than have been evaluated for safety during pregnancy/ postpartum and for efficacy in PPD.