It is often claimed that aspartame (and other nonnutritive sweeteners) can suppress appetite, cause weight loss, and improve aspects of cardiometabolic health (e.g., blood glucose control and cholesterol). Because aspartame is a nonnutritive sweetener that is used to replace sugar in some foods and drinks, some people with weight loss goals use aspartame-containing foods and drinks as part of an energy restriction diet. Reducing sugar intake as a way to lower total daily energy intake can help support a weight loss strategy,[1][2][3][4] and some,[5][6][7] but not all,[8][9] studies show that a single dose of aspartame can acutely reduce food intake at the next meal. However, the current evidence does not show long-term health benefits of aspartame on energy intake, weight loss, or cardiometabolic health.[10][11] Consequently, there does not appear to be any direct benefit from ingesting aspartame.