The specific cause of CVD depends on the type of CVD, but there are certain risk factors that increase the risk of developing the most common types of CVD. Large studies like the INTERHEART study (spanning 52 countries) and the Framingham Heart Study have found that the following factors are linked to a higher risk of developing CVD: smoking, dyslipidemia, high blood pressure, diabetes/glucose intolerance, abdominal obesity, physical inactivity, low consumption of fruits and vegetables, and psychosocial factors (e.g, depression, stress).[1]
What causes cardiovascular disease?
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•Last Updated: May 16, 2025
Cardiovascular disease (CVD) has various causes depending on its type, but common risk factors include smoking, dyslipidemia, high blood pressure, diabetes, abdominal obesity, physical inactivity, low fruit and vegetable intake, and psychosocial issues like depression and stress. Large studies have shown that these factors are associated with an increased risk of developing CVD.