GERD is a chronic condition characterized by the backflow (or reflux) of stomach contents into the esophagus and throat through a dysfunctional esophageal sphincter. Up to 1 out of 6 people are affected globally, but the prevalence varies widely between regions. Though it isn’t life-threatening, it does have a substantial negative impact on quality of life, and if left untreated, may increase the risk of esophageal cancer. The causes and disease progression of GERD aren’t completely understood, but it can be managed or treated with lifestyle modifications, drugs, and surgery.[1][2]
What is GERD?
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•Last Updated: May 16, 2025
Gastroesophageal reflux disease (GERD) is a chronic condition in which the stomach contents reflux into the esophagus due to a dysfunctional esophageal sphincter; it affects up to 1 in 6 people globally. Although it is not life-threatening, GERD can significantly affect quality of life and may increase the risk of esophageal cancer if untreated, but it can be managed through lifestyle changes, medications, and surgery.