Which supplements are of most interest for fat loss?

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    Last Updated: May 16, 2025

    Supplements for fat loss generally work by increasing energy expenditure, suppressing appetite, or enhancing fatty acid release from fat cells; popular options include caffeine, ephedrine, and green tea catechins. However, many fat loss supplements lack sufficient evidence for effectiveness and can potentially be harmful, as observed with yohimbine, ephedrine, and caffeine, which may induce anxiety in some individuals.

    Supplements of interest for fat loss typically either increase total daily energy expenditure, suppress appetite, or increase the rate at which fatty acids are released from fat cells. The following are some of the most popular supplements related to fat loss:

    Most supplements sold for fat loss are ineffective or there’s not enough evidence in humans to support their efficacy, and some can even be harmful. For example, yohimbine, ephedrine, and caffeine can all induce anxiety in some people.

    Which supplements are of most interest for fat loss? - Examine