Capsaicin

Last Updated: September 28 2022

The exact molecule found in hot peppers that burns your face off, acts via adrenaline receptors and TRPV1 (like Evodia) to increase heat quickly. Can burn body fat with minimal potency, fight inflammation with decent potency, and prevent cancer with indeterminate potency.

Capsaicin is most often used for

What else is Capsaicin known as?
Note that Capsaicin is also known as:
  • Chili extract
  • Hot pepper extract
  • trans-8-methyl-N-Vanilyl-6-nonenamide
  • Capsaicinoids
Capsaicin should not be confused with:
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    References
    2.^Szallasi A, Blumberg PMVanilloid (Capsaicin) receptors and mechanismsPharmacol Rev.(1999 Jun)
    6.^Luo XJ, Peng J, Li YJRecent advances in the study on capsaicinoids and capsinoidsEur J Pharmacol.(2011 Jan 10)
    9.^Kobata K, Sutoh K, Todo T, Yazawa S, Iwai K, Watanabe TNordihydrocapsiate, a new capsinoid from the fruits of a nonpungent pepper, capsicum annuumJ Nat Prod.(1999 Feb)
    10.^Ohnuki K, Haramizu S, Oki K, Watanabe T, Yazawa S, Fushiki TAdministration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in miceBiosci Biotechnol Biochem.(2001 Dec)
    11.^Ohnuki K, Niwa S, Maeda S, Inoue N, Yazawa S, Fushiki TCH-19 sweet, a non-pungent cultivar of red pepper, increased body temperature and oxygen consumption in humansBiosci Biotechnol Biochem.(2001 Sep)
    12.^Galgani JE, Ryan DH, Ravussin EEffect of capsinoids on energy metabolism in human subjectsBr J Nutr.(2010 Jan)
    13.^Yoshioka M, Imanaga M, Ueyama H, Yamane M, Kubo Y, Boivin A, St-Amand J, Tanaka H, Kiyonaga AMaximum tolerable dose of red pepper decreases fat intake independently of spicy sensation in the mouthBr J Nutr.(2004 Jun)
    15.^Craft RM, Porreca FTreatment parameters of desensitization to capsaicinLife Sci.(1992)
    17.^Reilly CA, Ehlhardt WJ, Jackson DA, Kulanthaivel P, Mutlib AE, Espina RJ, Moody DE, Crouch DJ, Yost GSMetabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cellsChem Res Toxicol.(2003 Mar)
    23.^Neuvonen PJ, Niemi M, Backman JTDrug interactions with lipid-lowering drugs: mechanisms and clinical relevanceClin Pharmacol Ther.(2006 Dec)
    25.^Montell C, Birnbaumer L, Flockerzi VThe TRP channels, a remarkably functional familyCell.(2002 Mar 8)
    28.^Szallasi A, Bíró T, Szabó T, Modarres S, Petersen M, Klusch A, Blumberg PM, Krause JE, Sterner OA non-pungent triprenyl phenol of fungal origin, scutigeral, stimulates rat dorsal root ganglion neurons via interaction at vanilloid receptorsBr J Pharmacol.(1999 Mar)
    29.^Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius DThe capsaicin receptor: a heat-activated ion channel in the pain pathwayNature.(1997 Oct 23)
    30.^Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, Julius DThe cloned capsaicin receptor integrates multiple pain-producing stimuliNeuron.(1998 Sep)
    31.^Schwartz ES, La JH, Scheff NN, Davis BM, Albers KM, Gebhart GFTRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitisJ Neurosci.(2013 Mar 27)
    32.^Koskela H, Purokivi M, Nieminen R, Moilanen EThe cough receptor TRPV1 agonists 15(S)-HETE and LTB4 in the cough response to hypertonicityInflamm Allergy Drug Targets.(2012 Apr)
    33.^Wen H, Östman J, Bubb KJ, Panayiotou C, Priestley JV, Baker MD, Ahluwalia A20-Hydroxyeicosatetraenoic acid (20-HETE) is a novel activator of transient receptor potential vanilloid 1 (TRPV1) channelJ Biol Chem.(2012 Apr 20)
    34.^Luo Z, Ma L, Zhao Z, He H, Yang D, Feng X, Ma S, Chen X, Zhu T, Cao T, Liu D, Nilius B, Huang Y, Yan Z, Zhu ZTRPV1 activation improves exercise endurance and energy metabolism through PGC-1α upregulation in miceCell Res.(2012 Mar)
    38.^Watanabe T, Kawada T, Kurosawa M, Sato A, Iwai KAdrenal sympathetic efferent nerve and catecholamine secretion excitation caused by capsaicin in ratsAm J Physiol.(1988 Jul)
    40.^Yoshioka M, Lim K, Kikuzato S, Kiyonaga A, Tanaka H, Shindo M, Suzuki MEffects of red-pepper diet on the energy metabolism in menJ Nutr Sci Vitaminol (Tokyo).(1995 Dec)
    42.^Zhang LL, Yan Liu D, Ma LQ, Luo ZD, Cao TB, Zhong J, Yan ZC, Wang LJ, Zhao ZG, Zhu SJ, Schrader M, Thilo F, Zhu ZM, Tepel MActivation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesityCirc Res.(2007 Apr 13)
    43.^Matsumoto T, Miyawaki C, Ue H, Yuasa T, Miyatsuji A, Moritani TEffects of capsaicin-containing yellow curry sauce on sympathetic nervous system activity and diet-induced thermogenesis in lean and obese young womenJ Nutr Sci Vitaminol (Tokyo).(2000 Dec)
    44.^Liddle RA, Nathan JDNeurogenic inflammation and pancreatitisPancreatology.(2004)
    45.^Schwartz ES, Christianson JA, Chen X, La JH, Davis BM, Albers KM, Gebhart GFSynergistic role of TRPV1 and TRPA1 in pancreatic pain and inflammationGastroenterology.(2011 Apr)
    46.^Gao SP, Bromberg JFTouched and moved by STAT3Sci STKE.(2006 Jul 11)
    48.^Yu H, Jove RThe STATs of cancer--new molecular targets come of ageNat Rev Cancer.(2004 Feb)
    49.^Oyagbemi AA, Saba AB, Azeez OICapsaicin: a novel chemopreventive molecule and its underlying molecular mechanisms of actionIndian J Cancer.(2010 Jan-Mar)
    50.^Bhutani M, Pathak AK, Nair AS, Kunnumakkara AB, Guha S, Sethi G, Aggarwal BBCapsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activationClin Cancer Res.(2007 May 15)
    51.^Lee HK, Seo IA, Shin YK, Park JW, Suh DJ, Park HTCapsaicin inhibits the IL-6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stressBiochem Biophys Res Commun.(2009 May 1)
    58.^Nilius B, Mahieu F, Karashima Y, Voets TRegulation of TRP channels: a voltage-lipid connectionBiochem Soc Trans.(2007 Feb)
    59.^Nilius B, Owsianik G, Voets T, Peters JATransient receptor potential cation channels in diseasePhysiol Rev.(2007 Jan)
    60.^Yoshioka M, St-Pierre S, Drapeau V, Dionne I, Doucet E, Suzuki M, Tremblay AEffects of red pepper on appetite and energy intakeBr J Nutr.(1999 Aug)
    61.^Westerterp-Plantenga MS, Smeets A, Lejeune MPSensory and gastrointestinal satiety effects of capsaicin on food intakeInt J Obes (Lond).(2005 Jun)
    64.^Kim KM, Kawada T, Ishihara K, Inoue K, Fushiki TIncrease in swimming endurance capacity of mice by capsaicin-induced adrenal catecholamine secretionBiosci Biotechnol Biochem.(1997 Oct)
    65.^Osaka T, Lee TH, Kobayashi A, Inoue S, Kimura SThermogenesis mediated by a capsaicin-sensitive area in the ventrolateral medullaNeuroreport.(2000 Aug 3)
    67.^Hursel R, Westerterp-Plantenga MSThermogenic ingredients and body weight regulationInt J Obes (Lond).(2010 Apr)
    68.^Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, Huang F, Xia H, Peters MF, Froehner SC, Bredt DSInteraction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domainsCell.(1996 Mar 8)
    69.^Lotteau S, Ducreux S, Romestaing C, Legrand C, Van Coppenolle FCharacterization of functional TRPV1 channels in the sarcoplasmic reticulum of mouse skeletal musclePLoS One.(2013)
    70.^Xin H, Tanaka H, Yamaguchi M, Takemori S, Nakamura A, Kohama KVanilloid receptor expressed in the sarcoplasmic reticulum of rat skeletal muscleBiochem Biophys Res Commun.(2005 Jul 8)
    72.^Yoshida T, Inoue R, Morii T, Takahashi N, Yamamoto S, Hara Y, Tominaga M, Shimizu S, Sato Y, Mori YNitric oxide activates TRP channels by cysteine S-nitrosylationNat Chem Biol.(2006 Nov)
    73.^Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BMTranscriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibresNature.(2002 Aug 15)
    74.^Wu H, Kanatous SB, Thurmond FA, Gallardo T, Isotani E, Bassel-Duby R, Williams RSRegulation of mitochondrial biogenesis in skeletal muscle by CaMKScience.(2002 Apr 12)
    75.^Naya FJ, Mercer B, Shelton J, Richardson JA, Williams RS, Olson ENStimulation of slow skeletal muscle fiber gene expression by calcineurin in vivoJ Biol Chem.(2000 Feb 18)
    79.^Keohane J, Quigley EMFunctional dyspepsia: the role of visceral hypersensitivity in its pathogenesisWorld J Gastroenterol.(2006 May 7)
    81.^Hammer J, Vogelsang HCharacterization of sensations induced by capsaicin in the upper gastrointestinal tractNeurogastroenterol Motil.(2007 Apr)
    83.^Führer M, Vogelsang H, Hammer JA placebo-controlled trial of an oral capsaicin load in patients with functional dyspepsiaNeurogastroenterol Motil.(2011 Oct)
    85.^Iwasaki Y, Morita A, Iwasawa T, Kobata K, Sekiwa Y, Morimitsu Y, Kubota K, Watanabe TA nonpungent component of steamed ginger--{10}-shogaol--increases adrenaline secretion via the activation of TRPV1Nutr Neurosci.(2006 Jun-Aug)
    86.^Iwasaki Y, Tanabe M, Kobata K, Watanabe TTRPA1 agonists--allyl isothiocyanate and cinnamaldehyde--induce adrenaline secretionBiosci Biotechnol Biochem.(2008 Oct)
    89.^Zhou XF, Marley PD, Livett BGRole of capsaicin-sensitive neurons in catecholamine secretion from rat adrenal glandsEur J Pharmacol.(1990 Sep 21)
    93.^Tanaka T, Kohno H, Sakata K, Yamada Y, Hirose Y, Sugie S, Mori HModifying effects of dietary capsaicin and rotenone on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesisCarcinogenesis.(2002 Aug)
    96.^Bode AM, Dong ZThe two faces of capsaicinCancer Res.(2011 Apr 15)
    98.^Jang JJ, Kim SH, Yun TKInhibitory effect of capsaicin on mouse lung tumor developmentIn Vivo.(1989 Jan-Feb)
    99.^Miller CH, Zhang Z, Hamilton SM, Teel RWEffects of capsaicin on liver microsomal metabolism of the tobacco-specific nitrosamine NNKCancer Lett.(1993 Nov 30)
    102.^Glinsukon T, Stitmunnaithum V, Toskulkao C, Buranawuti T, Tangkrisanavinont VAcute toxicity of capsaicin in several animal speciesToxicon.(1980)
    103.^Snyman T, Stewart MJ, Steenkamp VA fatal case of pepper poisoningForensic Sci Int.(2001 Dec 15)
    104.^Steffee CH, Lantz PE, Flannagan LM, Thompson RL, Jason DROleoresin capsicum (pepper) spray and "in-custody deaths"Am J Forensic Med Pathol.(1995 Sep)
    105.^Billmire DF, Vinocur C, Ginda M, Robinson NB, Panitch H, Friss H, Rubenstein D, Wiley JFPepper-spray-induced respiratory failure treated with extracorporeal membrane oxygenationPediatrics.(1996 Nov)
    106.^Walter AA, Herda TJ, Ryan ED, Costa PB, Hoge KM, Beck TW, Stout JR, Cramer JTAcute effects of a thermogenic nutritional supplement on cycling time to exhaustion and muscular strength in college-aged menJ Int Soc Sports Nutr.(2009 Jul 13)