Major depressive disorder (MDD) appears to have a genetic component to it, but it’s unknown how much of the disease is preventable. Along with other predictive markers of depression[1] (e.g. income) we can predict to some extent which individuals may be at higher risk of developing MDD. While numerous methods are used as preventive approaches, the brain-energetics side remains largely unexplored.
Overall, the current evidence is insufficient to recommend supplementation for MDD prevention. Nevertheless, because creatine supplementation is quite safe (with minimal to no side effects), it may prove to be a candidate for those at risk of depression, and the dose would also be relatively easy to titrate (always making sure you discuss your supplementation with your physician or health professional).