It is often claimed that aspartame (and other nonnutritive sweeteners) can suppress appetite, cause weight loss, and improve aspects of cardiometabolic health (e.g., blood glucose control and cholesterol). Because aspartame is a nonnutritive sweetener that is used to replace sugar in some foods and drinks, some people with weight loss goals use aspartame-containing foods and drinks as part of an energy restriction diet. Reducing sugar intake as a way to lower total daily energy intake can help support a weight loss strategy,[1][2][3][4] and some,[5][6][7] but not all,[8][9] studies show that a single dose of aspartame can acutely reduce food intake at the next meal. However, the current evidence does not show long-term health benefits of aspartame on energy intake, weight loss, or cardiometabolic health.[10][11] Consequently, there does not appear to be any direct benefit from ingesting aspartame.
References
- ^Tobiassen PA, Køster-Rasmussen RSubstitution of sugar-sweetened beverages with non-caloric alternatives and weight change: A systematic review of randomized trials and meta-analysis.Obes Rev.(2024-Feb)
- ^Néma D McGlynn, Tauseef Ahmad Khan, Lily Wang, Roselyn Zhang, Laura Chiavaroli, Fei Au-Yeung, Jennifer J Lee, Jarvis C Noronha, Elena M Comelli, Sonia Blanco Mejia, Amna Ahmed, Vasanti S Malik, James O Hill, Lawrence A Leiter, Arnav Agarwal, Per B Jeppesen, Dario Rahelic, Hana Kahleová, Jordi Salas-Salvadó, Cyril W C Kendall, John L SievenpiperAssociation of Low- and No-Calorie Sweetened Beverages as a Replacement for Sugar-Sweetened Beverages With Body Weight and Cardiometabolic Risk: A Systematic Review and Meta-analysisJAMA Netw Open.(2022 Mar 1)
- ^Chen L, Appel LJ, Loria C, Lin PH, Champagne CM, Elmer PJ, Ard JD, Mitchell D, Batch BC, Svetkey LP, Caballero BReduction in consumption of sugar-sweetened beverages is associated with weight loss: the PREMIER trial.Am J Clin Nutr.(2009-May)
- ^Blackburn GL, Kanders BS, Lavin PT, Keller SD, Whatley JThe effect of aspartame as part of a multidisciplinary weight-control program on short- and long-term control of body weight.Am J Clin Nutr.(1997-Feb)
- ^Rogers PJ, Burley VJ, Alikhanizadeh LA, Blundell JEPostingestive inhibition of food intake by aspartame: importance of interval between aspartame administration and subsequent eating.Physiol Behav.(1995-Mar)
- ^Rogers PJ, Blundell JEReanalysis of the effects of phenylalanine, alanine, and aspartame on food intake in human subjects.Physiol Behav.(1994-Aug)
- ^Rogers PJ, Keedwell P, Blundell JEFurther analysis of the short-term inhibition of food intake in humans by the dipeptide L-aspartyl-L-phenylalanine methyl ester (aspartame).Physiol Behav.(1991-Apr)
- ^Anton SD, Martin CK, Han H, Coulon S, Cefalu WT, Geiselman P, Williamson DAEffects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levelsAppetite.(2010 Aug)
- ^Lavin JH, French SJ, Read NWThe effect of sucrose- and aspartame-sweetened drinks on energy intake, hunger and food choice of female, moderately restrained eatersInt J Obes Relat Metab Disord.(1997 Jan)
- ^Santos NC, de Araujo LM, De Luca Canto G, Guerra ENS, Coelho MS, Borin MFMetabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trialsCrit Rev Food Sci Nutr.(2018)
- ^Higgins KA, Considine RV, Mattes RDAspartame Consumption for 12 Weeks Does Not Affect Glycemia, Appetite, or Body Weight of Healthy, Lean Adults in a Randomized Controlled TrialJ Nutr.(2018 Apr 1)