Psilocybin: Up-to-date evidence.

Examine Database: Psilocybin

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Health Condition/Goal	Health Outcome	Grade	Evidence	Effect
Cognitive Improvement	1 Outcome		1 Study

1 Outcome

1 Study

Long-term antidepressant effects of magic mushrooms are comparable to conventional medication

In this follow-up study to a randomized controlled trial in 46 adults with major depressive disorder who took psilocybin or escitalopram for 6 weeks, reductions in depression symptoms persisted at 6 months after intervention completion.

What are the short-term cognitive effects of psilocybin?

The case for psilocybin in depression treatment

Can a single dose of psilocybin help with severe treatment-resistant depression?

LSD longevity: Can psychedelics improve well-being in older adults?

Reaction Time - Yousefi P, Lietz MP, O'Higgins FJ, Rippe RCA, Hasler G, van Elk M, Enriquez-Geppert SAcute effects of psilocybin on attention and executive functioning in healthy volunteers: a systematic review and multilevel meta-analysis.Psychopharmacology (Berl).(2025 Jan 23)