Bipolar Disorder Symptoms

Last Updated: March 15, 2022

Bipolar disorder (a condition characterized by manic and depressive phases) may be influenced by various nutritional supplements, although one of the two phases may be unaffected while the other benefits.


Bipolar disorder (BPD) is a chronic or recurrent psychological disorder that affects more than 1% of the global population[1]. As shown in Figure 1, it is characterized by fluctuations in mood and energy[2] and marked by episodes of mania (great excitement, euphoria), hypomania (persistently elevated and/or irritable mood), and depression, BPD negatively impacts[3] quality of life and overall functioning. With its far-reaching impact on the lives of those who have it, BPD results in the highest suicide rate[4] among mood-related disorders, with a greater risk of suicide attempts during depressive episodes.


Examine Database: Bipolar Disorder Symptoms
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  1. ^Merikangas KR, Jin R, He JP, Kessler RC, Lee S, Sampson NA, Viana MC, Andrade LH, Hu C, Karam EG, Ladea M, Medina-Mora ME, Ono Y, Posada-Villa J, Sagar R, Wells JE, Zarkov ZPrevalence and correlates of bipolar spectrum disorder in the world mental health survey initiativeArch Gen Psychiatry.(2011 Mar)
  2. ^Hilty DM, Leamon MH, Lim RF, Kelly RH, Hales REA review of bipolar disorder in adultsPsychiatry (Edgmont).(2006 Sep)
  3. ^Sylvia LG, Montana RE, Deckersbach T, Thase ME, Tohen M, Reilly-Harrington N, McInnis MG, Kocsis JH, Bowden C, Calabrese J, Gao K, Ketter T, Shelton RC, McElroy SL, Friedman ES, Rabideau DJ, Nierenberg AAPoor quality of life and functioning in bipolar disorderInt J Bipolar Disord.(2017 Dec)
  4. ^Gonda X, Pompili M, Serafini G, Montebovi F, Campi S, Dome P, Duleba T, Girardi P, Rihmer ZSuicidal behavior in bipolar disorder: epidemiology, characteristics and major risk factorsJ Affect Disord.(2012 Dec 20)
Examine Database References
  1. Ashwagandha - Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal RRandomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorderJ Clin Psychiatry.(2013 Nov)
  2. CDP-Choline - Brown ES, Gorman AR, Hynan LSA randomized, placebo-controlled trial of citicoline add-on therapy in outpatients with bipolar disorder and cocaine dependenceJ Clin Psychopharmacol.(2007 Oct)
  3. Chromium - Amann BL, Mergl R, Vieta E, Born C, Hermisson I, Seemueller F, Dittmann S, Grunze HA 2-year, open-label pilot study of adjunctive chromium in patients with treatment-resistant rapid-cycling bipolar disorderJ Clin Psychopharmacol.(2007 Feb)
  4. Fish Oil - Hirashima F, Parow AM, Stoll AL, Demopulos CM, Damico KE, Rohan ML, Eskesen JG, Zuo CS, Cohen BM, Renshaw PFOmega-3 fatty acid treatment and T(2) whole brain relaxation times in bipolar disorderAm J Psychiatry.(2004 Oct)
  5. Inositol - Chengappa KN, Levine J, Gershon S, Mallinger AG, Hardan A, Vagnucci A, Pollock B, Luther J, Buttenfield J, Verfaille S, Kupfer DJInositol as an add-on treatment for bipolar depressionBipolar Disord.(2000 Mar)
  6. Uridine - Douglas G. Kondo, M.D, Young-Hoon Sung, M.D, Tracy L. Hellem, B.S, Kristen K. Delmastro, B.S, Eun-Kee Jeong, Ph.D, Namkug Kim, Ph.D, Xianfeng Shi, Ph.D, and Perry F. RenshawOpen-Label Uridine for Treatment of Depressed Adolescents with Bipolar DisorderJournal of Child and Adolescent Psychopharmacology.()
  7. Fish Oil - Keck PE Jr, Mintz J, McElroy SL, Freeman MP, Suppes T, Frye MA, Altshuler LL, Kupka R, Nolen WA, Leverich GS, Denicoff KD, Grunze H, Duan N, Post RMDouble-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorderBiol Psychiatry.(2006 Nov 1)
  8. Fish Oil - Murphy BL, Stoll AL, Harris PQ, Ravichandran C, Babb SM, Carlezon WA Jr, Cohen BMOmega-3 fatty acid treatment, with or without cytidine, fails to show therapeutic properties in bipolar disorder: a double-blind, randomized add-on clinical trialJ Clin Psychopharmacol.(2012 Oct)
  9. Inositol - Nierenberg AA, Ostacher MJ, Calabrese JR, Ketter TA, Marangell LB, Miklowitz DJ, Miyahara S, Bauer MS, Thase ME, Wisniewski SR, Sachs GSTreatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidoneAm J Psychiatry.(2006 Feb)
  10. Fish Oil - Frangou S, Lewis M, McCrone PEfficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised double-blind placebo-controlled studyBr J Psychiatry.(2006 Jan)
  11. Fish Oil - Stoll AL, Severus WE, Freeman MP, Rueter S, Zboyan HA, Diamond E, Cress KK, Marangell LBOmega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trialArch Gen Psychiatry.(1999 May)