Canker Sores Symptoms

•Last Updated: October 13, 2024

Canker sore is the common phrase used to refer to small ulcers in the mouth (Aphthous stomatitis), and many anti-ulcer compounds have been tested for their usage against canker sores in reducing inflammation and pain.

5,657 participants in 6 trials

Examine Evidence Grades

Last Updated:October 13, 2024

5,657 participants in 6 trials

Examine Evidence Grades

Examine Database: Canker Sores Symptoms

B

Participants: 140

Small Improvement

C

Participants: 84

Small Improvement

C

Participants: 115

Small Improvement

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Participants: 46

Participants: 5272

Intervention	Grade	Effect	Detail
Aloe Vera	B
Berberine	C
Lavender	C
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Licorice
Honey

Research FeedRead all studies

Can probiotics improve recurrent canker sores?

In this randomized controlled trial, probiotics + chitosan improved recurrent canker sore size and pain compared to a control.

Examine Database References

Aloe Vera - Babaee N, Zabihi E, Mohseni S, Moghadamnia AAEvaluation of the therapeutic effects of Aloe vera gel on minor recurrent aphthous stomatitisDent Res J (Isfahan).(2012 Jul)
Licorice - Martin MD, Sherman J, van der Ven P, Burgess JA controlled trial of a dissolving oral patch concerning glycyrrhiza (licorice) herbal extract for the treatment of aphthous ulcersGen Dent.(2008 Mar-Apr)
Aloe Vera - Bhalang K, Thunyakitpisal P, Rungsirisatean NAcemannan, a Polysaccharide Extracted from Aloe vera, Is Effective in the Treatment of Oral Aphthous UlcerationJ Altern Complement Med.(2012 Dec 16)
Berberine - Jiang XW, Zhang Y, Zhu YL, Zhang H, Lu K, Li FF, Peng HYEffects of berberine gelatin on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial in a Chinese cohortOral Surg Oral Med Oral Pathol Oral Radiol.(2012 Dec 12)
Lavender - Altaei DTTopical lavender oil for the treatment of recurrent aphthous ulcerationAm J Dent.(2012 Feb)
Honey - Liu H, Tan L, Fu G, Chen L, Tan HEfficacy of Topical Intervention for Recurrent Aphthous Stomatitis: A Network Meta-Analysis.Medicina (Kaunas).(2022 Jun 7)