Licorice (Glycyrrhiza plants, usually the Glabra species) have been used in Traditional Chinese Medicine to fairly good acclaim for various digestive and health problems, and as a general vitality promoting agent. Licorice is also routinely used as a candy product, and is inherently a functional food rather than just a candy (as the oil containing the traditional licorice flavor also contains some bioactive compounds).

One of the most important compounds in Licorice appears to be Glycyrrhizin, which is the sugar-bound form of Glycyrrhetic Acid (there exists both an alpha and beta isomer, with the latter 18β-Hydroxyglycyrrhetic acid being referred to frequently). This compound is highly relevant when consuming pure licorice extracts due to its good absorption and relatively high content, but also underlies a fairly reliable reduction in testosterone and a highly reliable increase in circulating cortisol after consumption. Both of these effects are dose-dependent and not associated with any toxicological effects (and reversed upon cessation of Licorice), but many persons may want to avoid Glycyrrhizin and Glycyrrhetic Acid due to these reasons.

An ethanolic extract of Licorice, sometimes used in supplements, is able to concentrate flavanoids and isoflavanoid compounds with a relatively low Glycyrrhizin content. Some of these flavanoids, including Glabridol as well as the Liquirtigenin class of flavanoids, appear to be the ones that exert properties that would be seen as 'beneficial'.