Examine Database: Constipation Signs and Symptoms
| Intervention | Grade | Effect | Detail |
|---|---|---|---|
| Senna | A | ||
| Probiotics | A | ||
| Inulin | B | ||
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| Kefir | |||
| Magnesium | |||
| Fermented Foods | |||
| Lactobacillus reuteri | |||
| Psyllium | |||
| Jujube | |||
| 16:8 Intermittent Fasting | |||
Research FeedRead all studies
Inulin can be helpful for constipation
In this randomized crossover trial in 39 adults (average age of 39; 92% women, 8% men) with constipation, supplementation with inulin increased stool frequency (the primary outcome) and reduced constipation symptoms.
The effects of probiotics on diarrhea and constipation in children
Curcumin’s effect on gastrointestinal symptoms in women with obesity
Fiber supplements and constipation in older people
Oats vs. rice for gastrointestinal and cardiometabolic health
Examine Database References
- Senna - Agra Y, Sacristán A, González M, Ferrari M, Portugués A, Calvo MJEfficacy of senna versus lactulose in terminal cancer patients treated with opioidsJ Pain Symptom Manage.(1998 Jan)
- Lactobacillus reuteri - Indrio F, Di Mauro A, Riezzo G, Civardi E, Intini C, Corvaglia L, Ballardini E, Bisceglia M, Cinquetti M, Brazzoduro E, Del Vecchio A, Tafuri S, Francavilla RProphylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trialJAMA Pediatr.(2014 Mar)
- Kefir - Gulbeyaz Can, Erkan Topuz, Duygu Derin, Zehra Durna, Adnan AydinerEffect of kefir on the quality of life of patients being treated for colorectal cancerOncol Nurs Forum.(2009 Nov)
- Senna - Patel M, Schimpf MO, O'Sullivan DM, LaSala CAThe use of senna with docusate for postoperative constipation after pelvic reconstructive surgery: a randomized, double-blind, placebo-controlled trialAm J Obstet Gynecol.(2010 May)
- Kefir - Daniel J Merenstein, Jennifer Foster, Frank D'AmicoA randomized clinical trial measuring the influence of kefir on antibiotic-associated diarrhea: the measuring the influence of Kefir (MILK) StudyArch Pediatr Adolesc Med.(2009 Aug)
- Senna - Shelton MGStandardized senna in the management of constipation in the puerperium: A clinical trialS Afr Med J.(1980 Jan 19)
- Senna - Sykes NPA volunteer model for the comparison of laxatives in opioid-related constipationJ Pain Symptom Manage.(1996 Jun)
- 16:8 Intermittent Fasting - Kelsey Gabel, Kristin K Hoddy, Krista A VaradySafety of 8-h time restricted feeding in adults with obesityAppl Physiol Nutr Metab.(2019 Jan)
- Lactobacillus reuteri - Coccorullo P, Strisciuglio C, Martinelli M, Miele E, Greco L, Staiano ALactobacillus reuteri (DSM 17938) in infants with functional chronic constipation: a double-blind, randomized, placebo-controlled studyJ Pediatr.(2010 Oct)
- Senna - Kinnunen O, Winblad I, Koistinen P, Salokannel JSafety and efficacy of a bulk laxative containing senna versus lactulose in the treatment of chronic constipation in geriatric patientsPharmacology.(1993 Oct)
- Jujube - Naftali T, Feingelernt H, Lesin Y, Rauchwarger A, Konikoff FMZiziphus jujuba extract for the treatment of chronic idiopathic constipation: a controlled clinical trialDigestion.(2008)
- Senna - Rogers HJ, House FR, Morrison PJ, Bradbrook IDComparison of the effect of drugs upon some commonly used measures of bowel transit timeBr J Clin Pharmacol.(1978 Dec)
- Kefir - İlker Turan, Özden Dedeli, Serhat Bor, Tankut İlterEffects of a kefir supplement on symptoms, colonic transit, and bowel satisfaction score in patients with chronic constipation: a pilot studyTurk J Gastroenterol.(2014 Dec)
- Magnesium - Morishita D, Tomita T, Mori S, Kimura T, Oshima T, Fukui H, Miwa HSenna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial.Am J Gastroenterol.(2021-Jan-01)
- Magnesium - Kubota M, Ito K, Tomimoto K, Kanazaki M, Tsukiyama K, Kubota A, Kuroki H, Fujita M, Vandenplas YLactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial.Nutrients.(2020-Jan-15)
- Magnesium - Mori S, Tomita T, Fujimura K, Asano H, Ogawa T, Yamasaki T, Kondo T, Kono T, Tozawa K, Oshima T, Fukui H, Kimura T, Watari J, Miwa HA Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation.J Neurogastroenterol Motil.(2019-Oct-30)
- Inulin - Collado Yurrita L, San Mauro Martín I, Ciudad-Cabañas MJ, Calle-Purón ME, Hernández Cabria MEffectiveness of inulin intake on indicators of chronic constipation; a meta-analysis of controlled randomized clinical trials.Nutr Hosp.(2014-Aug-01)
- Psyllium - van der Schoot A, Drysdale C, Whelan K, Dimidi EThe effect of fiber supplementation on chronic constipation in adults: an updated systematic review and meta-analysis of randomized controlled trials.Am J Clin Nutr.(2022-Jul-11)
- Probiotics - Li M, Xie YEfficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis.Front Cell Infect Microbiol.(2025)
- Probiotics - Siritientong T, Thet D, Leelakanok N, Areepium NOral probiotic supplementation to alleviate diarrhea induced by fluoropyrimidines or irinotecan-based chemotherapy: A systematic review and meta-analysis.Complement Ther Med.(2025 May)
- Fermented Foods - Mukherjee A, Farsi DN, Garcia-Gutierrez E, Akan E, Millan JAS, Angelovski L, Bintsis T, Gérard A, Güley Z, Kabakcı S, Kahala M, Merabti R, Pavli F, Salvetti E, Karagözlü C, Bağlam N, Hyseni B, Bavaro S, Papadimitriou K, Doo EH, Chassard C, Praćer S, Vergères G, Cotter PD, Mojsova SImpact of fermented foods consumption on gastrointestinal wellbeing in healthy adults: a systematic review and meta-analysis.Front Nutr.(2025)