Summary
DNA methylation is an epigenetic mechanism (i.e., a change in gene activity or function that is not associated with any change of the DNA sequence itself) involving the transfer of a methyl group to the C5 position of the cytosine ring of DNA.[1] It is essential for normal development and plays an important role in many key processes, such as repressing the expression of potentially harmful genetic elements.
Aging brings an increase in DNA methylation variability (i.e., an increase in DNA methylation in some tissues and a decrease in others) due to concurrent genetic and environmental influences.[2]
Examine Database: DNA methylation
| Intervention | Grade | Effect | Detail |
|---|---|---|---|
| Vitamin D | D | ||
| Resveratrol | C | ||
| Creatine | C | ||
| Omega-3 Fatty Acids |
Research FeedRead all studies
In this secondary analysis of a 3-year randomized controlled trial in 777 older adults, supplementation with omega-3-fatty acids alone or with vitamin D and resistance training slightly improved some markers of biological aging, compared with a placebo.
References
Examine Database References
- Resveratrol - Zhu W, Qin W, Zhang K, Rottinghaus GE, Chen YC, Kliethermes B, Sauter ERTrans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancerNutr Cancer.(2012 Apr)
- Creatine - Freilinger M, Dunkler D, Lanator I, Item CB, Mühl A, Fowler B, Bodamer OAEffects of creatine supplementation in Rett syndrome: a randomized, placebo-controlled trialJ Dev Behav Pediatr.(2011 Jul-Aug)
- Omega-3 Fatty Acids - Bischoff-Ferrari HA, Gängler S, Wieczorek M, Belsky DW, Ryan J, Kressig RW, Stähelin HB, Theiler R, Dawson-Hughes B, Rizzoli R, Vellas B, Rouch L, Guyonnet S, Egli A, Orav EJ, Willett W, Horvath SIndividual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial.Nat Aging.(2025 Mar)