Insomnia Signs and Symptoms

    Last Updated: October 13, 2024

    Insomnia is the inability to sleep or an excessive awakening during night that significantly impairs daily functioning. Supplements that improve sleep quality may also improve symptoms of insomnia. You may want to read our ten tips for better sleep.

    4,568 participants in 31 trials

    Examine Database: Insomnia Signs and Symptoms

    Research FeedRead all studies

    Examine Database References

    1. Saffron - Adrian L Lopresti, Stephen J Smith, Alexandra P Metse, Peter D DrummondEffects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trialJ Clin Sleep Med.(2020 Jun 15)
    2. Melatonin - Luthringer R, Muzet M, Zisapel N, Staner LThe effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomniaInt Clin Psychopharmacol.(2009 Sep)
    3. Melatonin - Alstadhaug KB, Odeh F, Salvesen R, Bekkelund SIProphylaxis of migraine with melatonin: a randomized controlled trialNeurology.(2010 Oct 26)
    4. Lavender - George T Lewith, Anthony Dean Godfrey, Philip PrescottA single-blinded, randomized pilot study evaluating the aroma of Lavandula augustifolia as a treatment for mild insomniaJ Altern Complement Med.(2005 Aug)
    5. Theanine - Sarris J, Byrne GJ, Cribb L, Oliver G, Murphy J, Macdonald P, Nazareth S, Karamacoska D, Galea S, Short A, Ee C, Birling Y, Menon R, Ng CHL-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trialJ Psychiatr Res.(2019 Mar)
    6. Panax Ginseng (Korean Ginseng) - Won-Suk Sung, Ha-Ra Kang, Chan-Yung Jung, Seong-Sik Park, Seung-Ho Lee, Eun-Jung KimEfficacy of Korean red ginseng (Panax ginseng) for middle-aged and moderate level of chronic fatigue patients: A randomized, double-blind, placebo-controlled trialComplement Ther Med.(2020 Jan)
    7. Ashwagandha - Auddy, B, et alA Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled StudyJ Am Nut Assn.()
    8. Ashwagandha - Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KIEffect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patientsIntegr Cancer Ther.(2013 Jul)
    9. Valerian - Taavoni S, Ekbatani N, Kashaniyan M, Haghani HEffect of valerian on sleep quality in postmenopausal women: a randomized placebo-controlled clinical trialMenopause.(2011 Sep)
    10. Rhodiola Rosea - Ross SMRhodiola rosea (SHR-5), Part 2: A standardized extract of Rhodiola rosea is shown to be effective in the treatment of mild to moderate depressionHolist Nurs Pract.(2014 May-Jun)
    11. Melatonin - van Geijlswijk IM, Mol RH, Egberts TC, Smits MGEvaluation of sleep, puberty and mental health in children with long-term melatonin treatment for chronic idiopathic childhood sleep onset insomniaPsychopharmacology (Berl).(2011 Jul)
    12. Ashwagandha - Sud Khyati S, Thaker Anup BA RANDOMIZED DOUBLE BLIND PLACEBO CONTROLLED STUDY OF ASHWAGANDHA ON GENERALIZED ANXIETY DISORDERInternational Ayurvedic Medical Journal .()
    13. Valerian - Cuellar NG, Ratcliffe SJDoes valerian improve sleepiness and symptom severity in people with restless legs syndromeAltern Ther Health Med.(2009 Mar-Apr)
    14. Zinc - Siahbazi S, Behboudi-Gandevani S, Moghaddam-Banaem L, Montazeri AEffect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trialJ Obstet Gynaecol Res.(2017 May)
    15. Lemon Balm - Cases J, Ibarra A, Feuillère N, Roller M, Sukkar SGPilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbancesMed J Nutrition Metab.(2011 Dec)
    16. 16:8 Intermittent Fasting - Kelsey Gabel, Kristin K Hoddy, Helen J Burgess, Krista A VaradyEffect of 8-h time-restricted feeding on sleep quality and duration in adults with obesityAppl Physiol Nutr Metab.(2019 Aug)
    17. Chaste tree - Ma L, Lin S, Chen R, Zhang Y, Chen F, Wang XEvaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese womenAust N Z J Obstet Gynaecol.(2010 Apr)
    18. Fish Oil - Behboudi-Gandevani S, Hariri FZ, Moghaddam-Banaem LThe effect of omega 3 fatty acid supplementation on premenstrual syndrome and health-related quality of life: a randomized clinical trialJ Psychosom Obstet Gynaecol.(2018 Dec)
    19. Melatonin - Lemoine P, Nir T, Laudon M, Zisapel NProlonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effectsJ Sleep Res.(2007 Dec)
    20. Magnesium - Behnood Abbasi, Masud Kimiagar, Khosro Sadeghniiat, Minoo M Shirazi, Mehdi Hedayati, Bahram RashidkhaniThe effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trialJ Res Med Sci.(2012 Dec)
    21. Magnesium - Jasmine Mah, Tyler PitreOral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-AnalysisBMC Complement Med Ther.(2021 Apr 17)
    22. Magnesium - Hornyak M, Voderholzer U, Hohagen F, Berger M, Riemann DMagnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study.Sleep.(1998-Aug-01)
    23. Bitter orange - Gutiérrez-Hellín J, Salinero JJ, Abían-Vicen J, Areces F, Lara B, Gallo C, Puente C, Del Coso JAcute consumption of p-synephrine does not enhance performance in sprint athletes.Appl Physiol Nutr Metab.(2016-Jan)
    24. Lavender - Dold M, Bartova L, Volz HP, Seifritz E, Möller HJ, Schläfke S, Kasper SEfficacy of Silexan in patients with anxiety disorders: a meta-analysis of randomized, placebo-controlled trials.Eur Arch Psychiatry Clin Neurosci.(2023-Jan-30)
    25. Cognitive Behavioral Therapy - Feng S, Dai B, Li H, Fu H, Zhou YEfficacy of cognitive behavioral therapy for insomnia in the perinatal period: a meta-analysis of randomized controlled trials.Sleep Biol Rhythms.(2024 Apr)
    26. Theanine - .(2024-06-16)
    27. Melatonin - Motlaq TM, Rahimi B, Amini SEffect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial.J Pharm Health Care Sci.(2024 May 30)
    28. Cognitive Behavioral Therapy - Malarkey ME, Fu AJ, Mannan N, Shaw OM, Haight TJ, Cota MR, Jahed NC, Werner JK, Brody DLInternet-Guided Cognitive Behavioral Therapy for Insomnia Among Patients With Traumatic Brain Injury: A Randomized Clinical Trial.JAMA Netw Open.(2024 Jul 1)
    29. Lemon Balm - Di Pierro F, Sisti D, Rocchi M, Belli A, Bertuccioli A, Cazzaniga M, Palazzi CM, Tanda ML, Zerbinati NEffects of Melissa officinalis Phytosome on Sleep Quality: Results of a Prospective, Double-Blind, Placebo-Controlled, and Cross-Over Study.Nutrients.(2024 Dec 4)
    30. Cognitive Behavioral Therapy - Mei Z, Cai C, Luo S, Zhang Y, Lam C, Luo SThe efficacy of cognitive behavioral therapy for insomnia in adolescents: a systematic review and meta-analysis of randomized controlled trials.Front Public Health.(2024)
    31. Light Therapy - Wang Y, Zhao X, Ren J, Xue S, Liu Y, Zhang L, Fan M, Su C, Cheng JXThe effect of light therapy on insomnia: A systematic review and meta-analysis.Sleep Breath.(2024 Dec 29)