Examine Database: Seizure Frequency
| Intervention | Grade | Effect | Detail |
|---|---|---|---|
| Ketogenic Diet | A | ||
| Cannabidiol (CBD) | A | ||
| Black seed | C | ||
| Folic Acid (Vitamin B9) |
Research FeedRead all studies
Cannabidiol may reduce seizure frequency in people with drug-resistant epilepsy
In this meta-analysis of 6 randomized controlled trials in a total of 1,334 participants with drug-resistant epilepsy, cannabidiol reduced seizure frequency 32% more than a placebo.
Does a modified Atkins diet reduce psychogenic non-epileptic seizures?
A ketogenic diet high in polyunsaturated fat reduces seizure rates but causes gastrointestinal side effects
The modified Atkins diet is beneficial for drug-resistant epilepsy
Melatonin and sleep in children with epilepsy
Examine Database References
- Cannabidiol (CBD) - Devinsky O, Patel AD, Cross JH, Villanueva V, Wirrell EC, Privitera M, Greenwood SM, Roberts C, Checketts D, VanLandingham KE, Zuberi SM, GWPCARE3 Study GroupEffect of Cannabidiol on Drop Seizures in the Lennox-Gastaut SyndromeN Engl J Med.(2018 May 17)
- Cannabidiol (CBD) - Devinsky O, Marsh E, Friedman D, Thiele E, Laux L, Sullivan J, Miller I, Flamini R, Wilfong A, Filloux F, Wong M, Tilton N, Bruno P, Bluvstein J, Hedlund J, Kamens R, Maclean J, Nangia S, Singhal NS, Wilson CA, Patel A, Cilio MRCannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trialLancet Neurol.(2016 Mar)
- Black seed - Akhondian J, Kianifar H, Raoofziaee M, Moayedpour A, Toosi MB, Khajedaluee MThe effect of thymoquinone on intractable pediatric seizures (pilot study)Epilepsy Res.(2011 Jan)
- Cannabidiol (CBD) - Hess EJ, Moody KA, Geffrey AL, Pollack SF, Skirvin LA, Bruno PL, Paolini JL, Thiele EACannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complexEpilepsia.(2016 Oct)
- Folic Acid (Vitamin B9) - Ranganathan LN, Ramaratnam SVitamins for epilepsy.Cochrane Database Syst Rev.(2005-Apr-18)
- Ketogenic Diet - Martin-McGill KJ, Bresnahan R, Levy RG, Cooper PNKetogenic diets for drug-resistant epilepsy.Cochrane Database Syst Rev.(2020-06-24)
- Ketogenic Diet - Jo Sourbron, Sylvia Klinkenberg, Sander M J van Kuijk, Lieven Lagae, Danielle Lambrechts, Hilde M H Braakman, Marian MajoieKetogenic diet for the treatment of pediatric epilepsy: review and meta-analysisChilds Nerv Syst.(2020 Jun)
- Ketogenic Diet - Mhanna A, Mhanna M, Beran A, Al-Chalabi M, Aladamat N, Mahfooz NModified Atkins diet versus ketogenic diet in children with drug-resistant epilepsy: A meta-analysis of comparative studies.Clin Nutr ESPEN.(2022 Oct)
- Ketogenic Diet - Devi N, Madaan P, Kandoth N, Bansal D, Sahu JKEfficacy and Safety of Dietary Therapies for Childhood Drug-Resistant Epilepsy: A Systematic Review and Network Meta-analysis.JAMA Pediatr.(2023 Mar 1)
- Cannabidiol (CBD) - de Oliveira VG, de Almeida NB, Radmann GC, de Oliveira Santos BFThe efficacy of cannabidiol for seizures reduction in pharmacoresistant epilepsy: a systematic review and meta-analysis.Acta Epileptol.(2025 Mar 17)