One study using 7-Keto in isolation at 200mg (100mg twice a day for 7 days) noted that, during a period of caloric restriction (800kcal less than regular intake), metabolic rate increased an average of 1.4% (total caloric expenditure a highly variable 21+/-115kcal) while placebo experienced a decrease in metabolic rate by 3.9% relative to baseline; this study was too short in duration to assess changes in weight.[34]
In accessing the metabolic rate, 7-Keto supplementation appears to attenuate or reverse the decline in metabolic rate associated with caloric restriction
Studies conducted over a longer period of time note that 200mg (100mg twice daily) for 8 weeks in obese adults in combination with a weight loss diet (1800kcal mixed diet) and exercise program (3 days weeks cross training) noted that the loss in weight associated with placebo (0.97kg) was increased (2.88kg) as well as the fat loss (from 0.57% to 1.8%); no significant differences in dietary intake were reported.[25]
Studies measuring weight loss associated with 7-keto note that supplementation results in more weight and fat loss over a period of time; both studies were paired with diet and exercise which may be prerequisites
Another trial (external funding source and confounded with Asparagus racemosus, choline, inositol, L-Tyrosine and minerals) noted that pairing 400mg 7-Keto (200mg twice daily) with a calorically restricted diet (25kcal/kg of target body weight) and exercise program for 8 weeks noted similar effects (increasing weight loss from 0.72+/-2.12kg in placebo to 2.15+/-2.38kg; high variability seemed to be due to exercise/diet intervention rather than supplementation as it occurred in placebo).[35]
One study using 7-keto at 200mg (alongside green tea catechins, chromium, Vitamin D, Vitamin C and calcium) during a period of caloric restriction in obese adults noted that the supplement was associated with a 3.4% increase in metabolic rate (59+/-118kcal) while placebo decreased 3.4%.[34] One study suggests a spike n 7.2% of the metabolic rate, but this study used a subactive dose of 7-Keto (17mg) paired with a variety of stimulatory compounds (Yerba Mate at 167mg, piper nigrum at 1.7mg, 50mg Coleus Forskohlii, 100mg Citris Aurantium at 6% Synephrine, and 233mg Guarana at 22% caffeine).[36]
Some studies suggest higher spikes in metabolic rate but are confounded with inclusion of other nutrients and not very respective of the bioactivity of 7-keto in isolation