Overview
What is agmatine?
What are agmatine’s main benefits?
What are agmatine’s main drawbacks?
How does agmatine work?
Dosage information
There are no standard dosages for agmatine because of the lack of human evidence for its effects. However, a single human study used 1,300-2,670mg of agmatine, daily for the treatment of neuropathic pain. The estimated human dose for improving cognition is 1.6-6.4mg/kg of agmatine, taken orally. This is based off of the 10-40mg/kg dosage range for rats, and is equivalent to 109-435mg for a 150lb person. Supplementation should not exceed 6.4mg/kg of bodyweight.
Studies on agmatine use a daily dosing protocol.
Agmatine is not absorbed well when taken with dietary protein, because it uses the same transporters as arginine. Further research is needed to determine if oral agmatine supplementation provides the same benefits as were observed in animal studies.
Examine Database: Agmatine
Frequently asked questions
What are other names for Agmatine?
Research Breakdown
References
Examine Database References
- Depression Symptoms - Baron ShopsinThe clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot studyActa Neuropsychiatrica.()
- Pain - Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GMSafety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. An Open-label, Dose-escalating Study Followed by a Randomized, Double-blind, Placebo-controlled TrialPain Med.(2010 Mar)