What is alpha-ketoglutarate?

    Last Updated: January 13, 2024

    AKG is a compound called a carboxylated keto acid. It is produced in the body naturally and is used in the Krebs cycle, a sequence of intracellular reactions that creates energy in the form of ATP. AKG is also important for several other metabolic and cellular processes. AKG helps maintain nitrogen balance within the body, is a precursor to several amino acids, is a source of energy for cells, and functions as an antioxidant. It is used to produce glutamine. Glutamine is an amino acid that is useful for muscle protein synthesis and for several important functions within the immune system.[1][2]

    References

    1. ^Gyanwali B, Lim ZX, Soh J, Lim C, Guan SP, Goh J, Maier AB, Kennedy BKAlpha-Ketoglutarate dietary supplementation to improve health in humans.Trends Endocrinol Metab.(2022-Feb)
    2. ^Liu, S and Yao, KThe Antioxidative Function of Alpha-Ketoglutarate and Its ApplicationsBiomed Res. Int..(2018-01)