Glutamine

Last Updated: September 28 2022

A conditionally essential amino acid which only appears to benefit the body as supplementation when otherwise deficient (vegans, vegetarians with low dairy intake) or during prolonged endurance exercise. Anecdotally reported to reduce sugar cravings.

Glutamine is most often used for

Summary

Glutamine is one of the 20 naturally occurring amino acids in dietary protein, specifically it is a conditionally essential amino acid (being elevated to essential during periods of disease and muscle wasting typical of physical trauma). It is sold as an isolated amino acids as well as being found in high levels in dietary meats and eggs. It is found in very high levels in both whey and casein protein.

Glutamine is a very effective intestinal and immune system health compound, as these cells use glutamine as the preferred fuel source rather than glucose.

It is generally touted as a muscle builder, but has not been proven to enhance muscle building in healthy individuals; only those suffering from physical trauma such as burns or muscular wounds (knife wounds) or in disease states in which muscle wasting occurs, such as AIDS. In these individuals, however, glutamine is effective at building muscle and alleviating a decrease in muscle mass typical of the ailment.

What else is Glutamine known as?
Note that Glutamine is also known as:
  • L-Glutamine
Glutamine should not be confused with:
Dosage information

Supplementation of L-glutamine tends to be dosed at 5 g or above, with higher doses being advised against due to excessive ammonia in serum. The lowest dose found to increase ammonia in serum has been 0.75 g/kg, or approximately 51 g for a 150 lb individual.

Due to the relative inefficacy of glutamine supplementation for increasing muscle mass, the optimal dosage is not known. The above recommended doses are sufficient for intestinal health reasons and for attenuating a possible relative glutamine deficiency (seen in instances of low protein intake or veganism).

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      References
      1.^Lenders CM, Liu S, Wilmore DW, Sampson L, Dougherty LW, Spiegelman D, Willett WCEvaluation of a novel food composition database that includes glutamine and other amino acids derived from gene sequencing dataEur J Clin Nutr.(2009 Dec)
      4.^Baxter JH, Phillips RR, Dowlati L, Johns PWGlutamine in commercial liquid nutritional productsJ Agric Food Chem.(2004 Aug 11)
      5.^Swails WS, Bell SJ, Borlase BC, Forse RA, Blackburn GLGlutamine content of whole proteins: implications for enteral formulasNutr Clin Pract.(1992 Apr)
      7.^Lacey JM, Wilmore DWIs glutamine a conditionally essential amino acidNutr Rev.(1990 Aug)
      11.^Lightfoot A, McArdle A, Griffiths RDMuscle in defenseCrit Care Med.(2009 Oct)
      15.^Boza JJ, Dangin M, Moënnoz D, Montigon F, Vuichoud J, Jarret A, Pouteau E, Gremaud G, Oguey-Araymon S, Courtois D, Woupeyi A, Finot PA, Ballèvre OFree and protein-bound glutamine have identical splanchnic extraction in healthy human volunteersAm J Physiol Gastrointest Liver Physiol.(2001 Jul)
      16.^Khogali SE, Pringle SD, Weryk BV, Rennie MJIs glutamine beneficial in ischemic heart diseaseNutrition.(2002 Feb)
      17.^Wischmeyer PE, Vanden Hoek TL, Li C, Shao Z, Ren H, Riehm J, Becker LBGlutamine preserves cardiomyocyte viability and enhances recovery of contractile function after ischemia-reperfusion injuryJPEN J Parenter Enteral Nutr.(2003 Mar-Apr)
      18.^Wischmeyer PE, Jayakar D, Williams U, Singleton KD, Riehm J, Bacha EA, Jeevanandam V, Christians U, Serkova NSingle dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injuryJPEN J Parenter Enteral Nutr.(2003 Nov-Dec)
      19.^Bolotin G, Raman J, Williams U, Bacha E, Kocherginsky M, Jeevanandam VGlutamine improves myocardial function following ischemia-reperfusion injuryAsian Cardiovasc Thorac Ann.(2007 Dec)
      22.^Domanski MJ, Mahaffey K, Hasselblad V, Brener SJ, Smith PK, Hillis G, Engoren M, Alexander JH, Levy JH, Chaitman BR, Broderick S, Mack MJ, Pieper KS, Farkouh MEAssociation of myocardial enzyme elevation and survival following coronary artery bypass graft surgeryJAMA.(2011 Feb 9)
      23.^Sufit A, Weitzel LB, Hamiel C, Queensland K, Dauber I, Rooyackers O, Wischmeyer PEPharmacologically dosed oral glutamine reduces myocardial injury in patients undergoing cardiac surgery: a randomized pilot feasibility trialJPEN J Parenter Enteral Nutr.(2012 Sep)
      24.^Lomivorotov VV, Efremov SM, Shmirev VA, Ponomarev DN, Lomivorotov VN, Karaskov AMGlutamine is cardioprotective in patients with ischemic heart disease following cardiopulmonary bypassHeart Surg Forum.(2011 Dec)
      26.^Ardawi MS, Newsholme EAGlutamine metabolism in lymphocytes of the ratBiochem J.(1983 Jun 15)
      27.^Parry-Billings M, Evans J, Calder PC, Newsholme EADoes glutamine contribute to immunosuppression after major burnsLancet.(1990 Sep 1)
      28.^Kim HGlutamine as an immunonutrientYonsei Med J.(2011 Nov)
      29.^MacLennan PA, Smith K, Weryk B, Watt PW, Rennie MJInhibition of protein breakdown by glutamine in perfused rat skeletal muscleFEBS Lett.(1988 Sep 12)
      31.^Zhou X, Thompson JRRegulation of protein turnover by glutamine in heat-shocked skeletal myotubesBiochim Biophys Acta.(1997 Jun 27)
      33.^Januszkiewicz A, Essén P, McNurlan MA, Calder GA, Andersson K, Wernerman J, Garlick PJEffect of a short-term infusion of glutamine on muscle protein metabolism postoperativelyClin Nutr.(1996 Oct)
      36.^Candow DG, Chilibeck PD, Burke DG, Davison KS, Smith-Palmer TEffect of glutamine supplementation combined with resistance training in young adultsEur J Appl Physiol.(2001 Dec)
      37.^Lehmkuhl M, Malone M, Justice B, Trone G, Pistilli E, Vinci D, Haff EE, Kilgore JL, Haff GGThe effects of 8 weeks of creatine monohydrate and glutamine supplementation on body composition and performance measuresJ Strength Cond Res.(2003 Aug)
      39.^Robson PJ, Blannin AK, Walsh NP, Castell LM, Gleeson MEffects of exercise intensity, duration and recovery on in vitro neutrophil function in male athletesInt J Sports Med.(1999 Feb)
      41.^Gleeson M, Walsh NP, Blannin AK, Robson PJ, Cook L, Donnelly AE, Day SHThe effect of severe eccentric exercise-induced muscle damage on plasma elastase, glutamine and zinc concentrationsEur J Appl Physiol Occup Physiol.(1998 May)
      42.^Parry-Billings M, Budgett R, Koutedakis Y, Blomstrand E, Brooks S, Williams C, Calder PC, Pilling S, Baigrie R, Newsholme EAPlasma amino acid concentrations in the overtraining syndrome: possible effects on the immune systemMed Sci Sports Exerc.(1992 Dec)
      43.^Rennie MJ, Edwards RH, Krywawych S, Davies CT, Halliday D, Waterlow JC, Millward DJEffect of exercise on protein turnover in manClin Sci (Lond).(1981 Nov)
      45.^Cury-Boaventura MF, Levada-Pires AC, Folador A, Gorjão R, Alba-Loureiro TC, Hirabara SM, Peres FP, Silva PR, Curi R, Pithon-Curi TCEffects of exercise on leukocyte death: prevention by hydrolyzed whey protein enriched with glutamine dipeptideEur J Appl Physiol.(2008 Jun)
      46.^Hiscock N, Petersen EW, Krzywkowski K, Boza J, Halkjaer-Kristensen J, Pedersen BKGlutamine supplementation further enhances exercise-induced plasma IL-6J Appl Physiol.(2003 Jul)
      47.^Parry-Billings M, Blomstrand E, McAndrew N, Newsholme EAA communicational link between skeletal muscle, brain, and cells of the immune systemInt J Sports Med.(1990 May)
      48.^Antonio J, Sanders MS, Kalman D, Woodgate D, Street CThe effects of high-dose glutamine ingestion on weightlifting performanceJ Strength Cond Res.(2002 Feb)
      49.^Carvalho-Peixoto J, Alves RC, Cameron LCGlutamine and carbohydrate supplements reduce ammonemia increase during endurance field exerciseAppl Physiol Nutr Metab.(2007 Dec)
      51.^Haub MD, Potteiger JA, Nau KL, Webster MJ, Zebas CJAcute L-glutamine ingestion does not improve maximal effort exerciseJ Sports Med Phys Fitness.(1998 Sep)
      52.^Claeyssens S, Bouteloup-Demange C, Gachon P, Hecketsweiler B, Lerebours E, Lavoinne A, Déchelotte PEffect of enteral glutamine on leucine, phenylalanine and glutamine metabolism in hypercortisolemic subjectsAm J Physiol Endocrinol Metab.(2000 May)
      54.^Bowtell JL, Gelly K, Jackman ML, Patel A, Simeoni M, Rennie MJEffect of oral glutamine on whole body carbohydrate storage during recovery from exhaustive exerciseJ Appl Physiol.(1999 Jun)
      55.^Coëffier M, Claeyssens S, Hecketsweiler B, Lavoinne A, Ducrotté P, Déchelotte PEnteral glutamine stimulates protein synthesis and decreases ubiquitin mRNA level in human gut mucosaAm J Physiol Gastrointest Liver Physiol.(2003 Aug)
      56.^Li N, Lewis P, Samuelson D, Liboni K, Neu JGlutamine regulates Caco-2 cell tight junction proteinsAm J Physiol Gastrointest Liver Physiol.(2004 Sep)
      57.^Potsic B, Holliday N, Lewis P, Samuelson D, DeMarco V, Neu JGlutamine supplementation and deprivation: effect on artificially reared rat small intestinal morphologyPediatr Res.(2002 Sep)
      60.^Seth A, Basuroy S, Sheth P, Rao RKL-Glutamine ameliorates acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayerAm J Physiol Gastrointest Liver Physiol.(2004 Sep)
      63.^Dugan ME, McBurney MILuminal glutamine perfusion alters endotoxin-related changes in ileal permeability of the pigletJPEN J Parenter Enteral Nutr.(1995 Jan-Feb)
      64.^Sevastiadou S, Malamitsi-Puchner A, Costalos C, Skouroliakou M, Briana DD, Antsaklis A, Roma-Giannikou EThe impact of oral glutamine supplementation on the intestinal permeability and incidence of necrotizing enterocolitis/septicemia in premature neonatesJ Matern Fetal Neonatal Med.(2011 Oct)
      65.^Lima NL, Soares AM, Mota RM, Monteiro HS, Guerrant RL, Lima AAWasting and intestinal barrier function in children taking alanyl-glutamine-supplemented enteral formulaJ Pediatr Gastroenterol Nutr.(2007 Mar)
      66.^van den Berg A, Fetter WP, Westerbeek EA, van der Vegt IM, van der Molen HR, van Elburg RMThe effect of glutamine-enriched enteral nutrition on intestinal permeability in very-low-birth-weight infants: a randomized controlled trialJPEN J Parenter Enteral Nutr.(2006 Sep-Oct)
      67.^Luo M, Bazargan N, Griffith DP, Estívariz CF, Leader LM, Easley KA, Daignault NM, Hao L, Meddings JB, Galloway JR, Blumberg JB, Jones DP, Ziegler TRMetabolic effects of enteral versus parenteral alanyl-glutamine dipeptide administration in critically ill patients receiving enteral feeding: a pilot studyClin Nutr.(2008 Apr)
      69.^Den Hond E, Hiele M, Peeters M, Ghoos Y, Rutgeerts PEffect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn's diseaseJPEN J Parenter Enteral Nutr.(1999 Jan-Feb)
      70.^Akobeng AK, Miller V, Thomas AG, Richmond KGlutamine supplementation and intestinal permeability in Crohn's diseaseJPEN J Parenter Enteral Nutr.(2000 May-Jun)
      72.^Ockenga J, Borchert K, Stüber E, Lochs H, Manns MP, Bischoff SCGlutamine-enriched total parenteral nutrition in patients with inflammatory bowel diseaseEur J Clin Nutr.(2005 Nov)
      73.^Benjamin J, Makharia G, Ahuja V, Anand Rajan KD, Kalaivani M, Gupta SD, Joshi YKGlutamine and whey protein improve intestinal permeability and morphology in patients with Crohn's disease: a randomized controlled trialDig Dis Sci.(2012 Apr)
      74.^van der Hulst RR, van Kreel BK, von Meyenfeldt MF, Brummer RJ, Arends JW, Deutz NE, Soeters PBGlutamine and the preservation of gut integrityLancet.(1993 May 29)
      75.^Silva AC, Santos-Neto MS, Soares AM, Fonteles MC, Guerrant RL, Lima AAEfficacy of a glutamine-based oral rehydration solution on the electrolyte and water absorption in a rabbit model of secretory diarrhea induced by cholera toxinJ Pediatr Gastroenterol Nutr.(1998 May)
      76.^Stinnett JD, Alexander JW, Watanabe C, MacMillan BG, Fischer JE, Morris MJ, Trocki O, Miskell P, Edwards L, James HPlasma and skeletal muscle amino acids following severe burn injury in patients and experimental animalsAnn Surg.(1982 Jan)
      78.^Neu J, Shenoy V, Chakrabarti RGlutamine nutrition and metabolism: where do we go from here ?FASEB J.(1996 Jun)
      79.^Mittendorfer B, Gore DC, Herndon DN, Wolfe RRAccelerated glutamine synthesis in critically ill patients cannot maintain normal intramuscular free glutamine concentrationJPEN J Parenter Enteral Nutr.(1999 Sep-Oct)
      82.^Fan YP, Yu JC, Kang WM, Zhang QEffects of glutamine supplementation on patients undergoing abdominal surgeryChin Med Sci J.(2009 Mar)
      83.^Shao A, Hathcock JNRisk assessment for the amino acids taurine, L-glutamine and L-arginineRegul Toxicol Pharmacol.(2008 Apr)
      85.^Roth ENonnutritive effects of glutamineJ Nutr.(2008 Oct)
      86.^Ward E, Picton S, Reid U, Thomas D, Gardener C, Smith M, Henderson M, Holden V, Kinsey S, Lewis I, Allgar VOral glutamine in paediatric oncology patients: a dose finding studyEur J Clin Nutr.(2003 Jan)
      87.^Galera SC, Fechine FV, Teixeira MJ, Coelho ZC, de Vasconcelos RC, de Vasconcelos PRThe safety of oral use of L-glutamine in middle-aged and elderly individualsNutrition.(2010 Apr)