Does berberine affect immune health and function?

A more recent topic of exploration has been berberine’s immune modulation through reductions in inflammatory biomarkers (IL-6, IL-1-beta, CRP, and TNF-α) generally in those already with some form of metabolic distress (diabetes, metabolic syndrome, cardiovascular disease).^{[1][2][3][4][5]} In another apparent connection between berberine and immune health, three recent studies suggest that berberine (0.3-0.6 g/d) could reduce recurrence of colorectal polyps in those with a history of colorectal cancer, when compared to placebo controls.^[6] Though more recent results may be a bit more promising, caution is warranted since there are still some concerns over the quality (and sometimes quantity) of the studies producing the findings.^[7]