Beta-glucans usually come as a powder that may be loose or in capsules. Oat and barley beta-glucans generally require larger doses, which is more easily achieved with a loose powder that can be added to food or beverages.

For lowering cholesterol, taking oat or barley beta-glucans orally at a dosage of at least 3 grams daily is recommended.^[1] If choosing to supplement with whole foods, this can also be achieved with about 75 grams (2.6 ounces) of whole grain oats, 55 grams (2 ounces) of oat bran, or 45 grams (1.6 ounces) of barley.^[2]

For lowering postmeal increases in blood glucose and insulin levels, adding around 3 grams (0.1 ounce) of oat beta-glucans per 30 grams (1 ounce) of carbohydrates seems to be effective.^[3]

For reducing the incidence and duration of upper respiratory tract infections, taking yeast beta-glucans orally at a dosage of 250 mg daily for at least 4 weeks may be effective.^[4]