1.
Effects in the Brain
Centrophenoxine is able to reverse lipofuscin/beta-amyloid pigmentation build-up as well as act as an anti-oxidant against lipid peroxidation.[1] Centrophenoxine can also increase RNA synthesis, protein synthesis, and glucose uptake in neurons and glial (support) cells. These latter effects are, however, dependent on the reductions of lipofuscin build-up[2] and don't appear to affect youth with no lipofuscin build-up.[3]
2.
Dementia
Centrophenoxine has been shown to be efficacious in treating dementia by increasing intracellular water content (of which dehydration is consistent with aging) and by increasing skills on cognition testing after 8 weeks of a 2g dose.[4]
3.
Teratogenicity
Centrophenoxine, via its DMAE moiety, may act as a teratogen in the same manner as DMAE which can be reviewed under DMAE's Teratogenic Summary
References
- ^Sharma D, Maurya AK, Singh RAge-related decline in multiple unit action potentials of CA3 region of rat hippocampus: correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxineNeurobiol Aging.(1993 Jul-Aug)
- ^Ludwig-Festl M, Gräter B, Bayreuther KIncrease in cell metabolism in normal, diploid human glial cells in stationary cell cultures induced by meclofenoxateArzneimittelforschung.(1983)
- ^Watanabe S, Kono S, Nakashima Y, Mitsunobu K, Otsuki SEffects of various cerebral metabolic activators on glucose metabolism of brainFolia Psychiatr Neurol Jpn.(1975)
- ^Fülöp T Jr, Wórum I, Csongor J, Leövey A, Szabó T, Pék G, Zs -Nagy IEffects of centrophenoxine on body composition and some biochemical parameters of demented elderly people as revealed in a double-blind clinical trialArch Gerontol Geriatr.(1990 May-Jun)